Patents by Inventor Anthony M. De Marco

Anthony M. De Marco has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing 1-beta-methylcarbapenem antibiotic intermediates
    Patent number: 4816577
    Abstract: A process for isomerizing an alpha methylated azetidinone alkyl ester to the corresponding beta-methyl isomer, which is an intermediate in the synthesis of 1-beta-methylcarbapenem antibacterial agents. The process involves treating the dianion of structure I, being the alpha isomer, with a P-H or S-H containing organic protic acid, organometallic Sn or Pb hydride, metallic cation salt or trialkyl borane, followed by quenching with an OH protic organic acid or mineral acid.
    Type: Grant
    Filed: December 16, 1987
    Date of Patent: March 28, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Dean R. Bender, Ichiro Shinkai, Anthony M. De Marco, James A. McCauley