Patents by Inventor Anthony M. Rush

Anthony M. Rush has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RETROGRADE NEURONAL TRACERS DETECTABLE BY FLUORESCENCE AND OTHER IMAGING METHODS
    Publication number: 20230203369
    Abstract: Disclosed is composition comprising: a first fluorophore moiety, and nanoparticles, wherein the nanoparticles comprise: a first plurality of a first nanoparticle, the first nanoparticle comprising: a first outer surface, a first interior bulk, and a first polymer, wherein the first polymer is covalently bonded to the first fluorophore moiety within the first interior bulk of the first nanoparticle. Also disclosed is a composition comprising: a chelate moiety, and nanoparticles, wherein the nanoparticles comprise: a plurality of a chelate nanoparticle, the chelate nanoparticle comprising: an outer surface, an interior bulk, and a polymer, wherein the polymer is covalently bonded to the chelate moiety within the interior bulk of the chelate nanoparticle. Also disclosed are methods of making such compositions and using such composition for brain mapping and tracing of axonal projections.
    Type: Application
    Filed: February 12, 2021
    Publication date: June 29, 2023
    Applicants: NORTHWESTERN UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, HOWARD HUGHES MEDICAL INSTITUTE
    Inventors: Nathan C. GIANNESCHI, Nanzhi ZANG, Massimo SCANZIANI, Dante S. BORTONE, Treffly B. DITRI, Anthony M. RUSH
  • COMPOSITIONS AND METHODS OF MAKING POLYMERIZING NUCLEIC ACIDS
    Publication number: 20210301078
    Abstract: Provided herein are compositions and methods of making high density nucleic acid polymers.
    Type: Application
    Filed: February 10, 2021
    Publication date: September 30, 2021
    Applicant: The Regents of the University of California
    Inventors: Anthony M. RUSH, Nathan GIANNESCHI, Carrie JAMES
  • Compositions and methods of making polymerizing nucleic acids
    Patent number: 11072681
    Abstract: Provided herein are compositions and methods of making high density nucleic acid polymers.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: July 27, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Anthony M. Rush, Nathan Gianneschi, Carrie James
  • Methods for arranging and packing nucleic acids for unusual resistance to nucleases and targeted delivery for gene therapy
    Patent number: 10046057
    Abstract: There are disclosed compositions and methods to render nucleic acids resistant to nuclease digestion while maintaining sequence selective hybridization competency. The approach relies on utilizing nucleic acids as the polar head group of a nucleic acid-polymer amphiphile in order to assemble well-defined, discrete micellar nanoparticles. Dense packing of nucleic acid in the micelle corona allows for hybridization of complementary oligonucleotides while prohibiting enzymatic degradation.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: August 14, 2018
    Assignee: The Regents of the University of California
    Inventors: Erick T. Tatro, Nathan Gianneschi, Anthony M. Rush
  • COMPOSITIONS AND METHODS OF MAKING POLYMERIZING NUCLEIC ACIDS
    Publication number: 20170327633
    Abstract: Provided herein are compositions and methods of making high density nucleic acid polymers.
    Type: Application
    Filed: July 28, 2015
    Publication date: November 16, 2017
    Inventors: Anthony M. Rush, Nathan Gianneschi, Carrie James
  • METHODS FOR ARRANGING AND PACKING NUCLEIC ACIDS FOR UNUSUAL RESISTANCE TO NUCLEASES AND TARGETED DELIVERY FOR GENE THERAPY
    Publication number: 20150190525
    Abstract: There are disclosed compositions and methods to render nucleic acids resistant to nuclease digestion while maintaining sequence selective hybridization competency. The approach relies on utilizing nucleic acids as the polar head group of a nucleic acid-polymer amphiphile in order to assemble well-defined, discrete micellar nanoparticles. Dense packing of nucleic acid in the micelle corona allows for hybridization of complementary oligonucleotides while prohibiting enzymatic degradation.
    Type: Application
    Filed: March 24, 2015
    Publication date: July 9, 2015
    Inventors: Erick T. Tatro, Nathan Gianneschi, Anthony M. Rush