Patents by Inventor Anthony M. Stepan

Anthony M. Stepan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amplifiable adeno-associated virus(AAV) packaging cassettes for the production of recombinant AAV vectors
    Patent number: 6642051
    Abstract: High-efficiency AAV packaging constructs and methods for their use are provided. in the present invention. These high-efficiency packaging constructs comprise an activating element (such as the P1 sequence located within the AAV S1 integration site of human chromosome 19) amplifiably linked to one or more AAV packaging genes. The constructs may be either integrated into a mammalian cell genome or maintained episomally. Use of the high-efficiency AAV packaging vectors of the invention provides for controlled amplifiable production of rAAV vector constructs.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: November 4, 2003
    Assignee: Targeted Genetics Corporation
    Inventors: Carmel M. Lynch, Haim Burstein, Anthony M. Stepan, Dara H. Lockert
  • Methods and compositions for lowering the level of tumor necrosis factor (TNF) in TNF-associated disorders
    Publication number: 20030113295
    Abstract: The present invention provides recombinant adeno-associated virus (rAAV) vectors encoding a tumor necrosis factor (TNF) antagonist and methods using these vectors to reduce levels of TNF in a mammal. The invention also provides methods of using these rAAV vectors in palliating TNF-associated disorders.
    Type: Application
    Filed: December 6, 2002
    Publication date: June 19, 2003
    Inventors: Haim Burstein, Anthony M. Stepan
  • Methods and compositions for lowering the level of tumor necrosis factor (TNF) in TNF-associated disorders
    Publication number: 20030103942
    Abstract: The present invention provides recombinant adeno-associated virus (rAAV) vectors encoding a tumor necrosis factor (TNF) antagonist and methods using these vectors to reduce levels of TNF in a mammal. The invention also provides methods of using these rAAV vectors in palliating TNF-associated disorders.
    Type: Application
    Filed: December 6, 2002
    Publication date: June 5, 2003
    Inventors: Haim Burstein, Anthony M. Stepan
  • AAV split-packaging genes and cell lines comprising such genes for use in the production of recombinant AAV vectors
    Patent number: 6541258
    Abstract: The present invention provides AAV “split-packaging” genes, and packaging cells comprising such genes, for use in the production of high titers of replication-incompetent recombinant AAV vectors that can be used to deliver transgenes of interest to a variety of mammalian cells.
    Type: Grant
    Filed: December 12, 1997
    Date of Patent: April 1, 2003
    Assignee: Targeted Genetics Corporation
    Inventors: James M. Allen, Anthony M. Stepan, Tineka J. Quinton, Stephen D. Lupton
  • Methods and composition for lowering the level of tumor necrosis factor (TNF) in TNF-associated disorders
    Patent number: 6537540
    Abstract: The present invention provides recombinant adeno-associated virus (rAAV) vectors encoding a tumor necrosis factor (TNF) antagonist and methods using these vectors to reduce levels of TNF in a mammal. The invention also provides methods of using these rAAV vectors in palliating TNF-associated disorders.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: March 25, 2003
    Assignee: Targeted Genetics Corporation
    Inventors: Haim Burstein, Anthony M. Stepan
  • AAV SPLIT-PACKAGING GENES AND CELL LINES COMPRISING SUCH GENES FOR USE IN THE PRODUCTION OF RECOMBINANT AAV VECTORS
    Publication number: 20020081721
    Abstract: The present invention provides AAV “split-packaging” genes, and packaging cells comprising such genes, for use in the production of high titers of replication-incompetent recombinant AAV vectors that can be used to deliver transgenes of interest to a variety of mammalian cells.
    Type: Application
    Filed: December 12, 1997
    Publication date: June 27, 2002
    Inventors: JAMES M. ALLEN, ANTHONY M. STEPAN, TINEKA J. QUINTON, STEPHEN D. LUPTON