Patents by Inventor Anthony Marfat

Anthony Marfat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxabicycloheptane prodrugs
    Patent number: 11866444
    Abstract: The present invention provides a compound having the structure:
    Type: Grant
    Filed: January 27, 2022
    Date of Patent: January 9, 2024
    Assignee: Lixte Biotechnology, Inc.
    Inventors: John S. Kovach, Robert A. Volkmann, Anthony Marfat
  • OXABICYCLOHEPTANE PRODRUGS
    Publication number: 20220235066
    Abstract: The present invention provides a compound having the structure:
    Type: Application
    Filed: January 27, 2022
    Publication date: July 28, 2022
    Inventors: John S. KOVACH, Robert VOLKMANN, Anthony MARFAT
  • Oxabicycloheptane prodrugs
    Patent number: 11236102
    Abstract: The present invention provides a compound having the structure:
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: February 1, 2022
    Assignee: Lixte Biotechnology, Inc.
    Inventors: John S. Kovach, Robert Volkmann, Anthony Marfat
  • Amine prodrugs of pharmaceutical compounds
    Patent number: 11083711
    Abstract: Disclose are amine prodrugs and methods of synthesis thereof. In particular, the amine prodrug comprises a drug molecule and at least one or more prodrug appendage moieties and the method for synthesis the amine prodrug comprises a step of coupling the drug molecule and at least one or more prodrug appendage moieties. Also disclosed are exemplary riluzole prodrugs and methods of synthesis thereof.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: August 10, 2021
    Assignee: Biohaven Therapeutics Ltd.
    Inventor: Anthony Marfat
  • PYRIDINONE AND PYRIMIDINONE PHOSPHATES AND BORONATES USEFUL AS ANTIBACTERIAL AGENTS
    Publication number: 20210017206
    Abstract: The present invention is directed to new pyridinone or pyrimidinone hydroxamic acid phosphates of Formula (1) and boronates of Formula (2), stereoisomers thereof; wherein Q is selected from the group consisting of —P(O)(OH)2, —P(O)(OH)(O?M+), —P(O)(O?M+)2 and —P(O)(O?)2M2+; M+ at each occurrence is a pharmaceutically acceptable monovalent cation; and M2+ is a pharmaceutically acceptable divalent cation; X is CH or N; and Z is as defined herein; and their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.
    Type: Application
    Filed: March 14, 2019
    Publication date: January 21, 2021
    Inventors: Matthew Frank Brown, Ye Che, Anthony Marfat, Michael Joseph Melnick, Justin Ian Montgomery, Timothy Allan Johnson, Richard Andrew Ewin, Daniel Paul Uccello, Usa Reilly, Tamim Fehme Braish
  • OXABICYCLOHEPTANE PRODRUGS
    Publication number: 20200325151
    Abstract: The present invention provides a compound having the structure:
    Type: Application
    Filed: February 5, 2020
    Publication date: October 15, 2020
    Inventors: John S. KOVACH, Robert VOLKMANN, Anthony MARFAT
  • Oxabicycloheptane prodrugs
    Patent number: 10618908
    Abstract: The present invention provides a compound having the structure:
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: April 14, 2020
    Assignee: Lixte Biotechnology, Inc.
    Inventors: John S. Kovach, Robert Volkmann, Anthony Marfat
  • AMINE PRODRUGS OF PHARMACEUTICAL COMPOUNDS
    Publication number: 20190365721
    Abstract: Disclose are amine prodrugs and methods of synthesis thereof. In particular, the amine prodrug comprises a drug molecule and at least one or more prodrug appendage moieties and the method for synthesis the amine prodrug comprises a step of coupling the drug molecule and at least one or more prodrug appendage moieties. Also disclosed are exemplary riluzole prodrugs and methods of synthesis thereof.
    Type: Application
    Filed: August 19, 2019
    Publication date: December 5, 2019
    Inventor: Anthony Marfat
  • OXABICYCLOHEPTANE PRODRUGS
    Publication number: 20190359627
    Abstract: The present invention provides a compound having the structure:
    Type: Application
    Filed: June 12, 2019
    Publication date: November 28, 2019
    Inventors: John S. Kovach, Robert Volkmann, Anthony Marfat
  • Octahydrocyclopenta[c]pyrrole allosteric inhibitors of SHP2
    Patent number: 10435389
    Abstract: The present invention relates to compounds capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds, and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: October 8, 2019
    Assignee: Krouzon Pharmaccuticals, Inc.
    Inventors: Robert Volkmann, Anthony Marfat, Frederick Nelson, Panayiotis Zagouras
  • HYDROXYNORKETAMINE PRODRUGS
    Publication number: 20190256487
    Abstract: Disclosed are novel ketamine prodrugs, pharmaceutical preparations containing such prodrugs of ketamine and methods of treating, bipolar depression, neuropathic and chronic pain, including complex regional pain synthetic pain syndrome (CRPS) by administering such prodrugs to patients in need of such treatment.
    Type: Application
    Filed: September 15, 2017
    Publication date: August 22, 2019
    Inventors: Robert A. Volkmann, Anthony Marfat
  • Oxabicycloheptane prodrugs
    Patent number: 10364252
    Abstract: The present invention provides a compound having the structure:
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: July 30, 2019
    Assignee: Lixte Biotechnology, Inc.
    Inventors: John S. Kovach, Robert Volkmann, Anthony Marfat
  • Octahydrocyclopenta[c]pyrrole Allosteric Inhibitors of SHP2
    Publication number: 20190077792
    Abstract: The present invention relates to compounds capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds, and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
    Type: Application
    Filed: September 11, 2018
    Publication date: March 14, 2019
    Inventors: Robert Volkmann, Anthony Marfat, Frederick Nelson, Panayiotis Zagouras
  • COMPOUNDS FOR TREATMENT OF PAIN
    Publication number: 20190002473
    Abstract: The aspects of the disclosed embodiments are directed to novel compounds, formulations containing said compounds or pharmaceutically acceptable salts thereof which are suitable for administration to a patient.
    Type: Application
    Filed: September 7, 2018
    Publication date: January 3, 2019
    Inventors: Robert Volkmann, Anthony Marfat, Peter Cornelius, Panayiotis Zagouras, Fredrick Raymond Nelson, Anton Franz Joseph Fliri
  • AMINE PRODRUGS OF PHARMACEUTICAL COMPOUNDS
    Publication number: 20180318268
    Abstract: Disclose are amine prodrugs and methods of synthesis thereof. In particular, the amine prodrug comprises a drug molecule and at least one or more prodrug appendage moieties and the method for synthesis the amine prodmg comprises a step of coupling the drag molecule and at least one or more prodrug appendage moieties. Also disclosed are exemplary riluzole prodrugs and methods of synthesis thereof.
    Type: Application
    Filed: November 17, 2016
    Publication date: November 8, 2018
    Inventor: Anthony Marfat
  • Compounds for treatment of pain
    Patent number: 10072018
    Abstract: The aspects of the disclosed embodiments are directed to novel compounds, specifically, quaternary ammonium derivatives of tertiary amine containing opioid drug compounds such as hydrocodone, hydromorphone and oxycodone, formulations containing said. compounds or pharmaceutically acceptable salts thereof, which are capable of providing controlled release of the opioid drug upon administration to a patient in order to treat pain.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: September 11, 2018
    Assignee: BIOPHARMA WORKS
    Inventors: Robert Volkmann, Anthony Marfat, Peter Cornelius, Panayiotis Zagouras, Fredrick Raymond Nelson, Anton Franz Joseph Fliri
  • OXABICYCLOHEPTANE PRODRUGS
    Publication number: 20180244690
    Abstract: The present invention provides a compound having the structure:
    Type: Application
    Filed: May 1, 2018
    Publication date: August 30, 2018
    Applicant: Lixte Biotechnology, Inc.
    Inventors: John S. Kovach, Robert Volkmann, Anthony Marfat
  • Prodrug derivatives of (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
    Patent number: 10035813
    Abstract: In part, the present disclosure is directed to prodrug derivatives of (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide compounds with significant solubility and bioavailability profiles.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: July 31, 2018
    Assignee: Debiopharm International SA
    Inventors: John J. Partridge, John Colucci, Yves Gareau, Michel Therien, Robert Zamboni, Barry Hafkin, Anthony Marfat, Helmi Zaghdane
  • Oxabicycloheptane prodrugs
    Patent number: 9988394
    Abstract: The present invention provides a compound having the structure:
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: June 5, 2018
    Assignee: Lixte Biotechnology Inc.
    Inventors: John S. Kovach, Robert Volkmann, Anthony Marfat
  • GANAXOLONE DERIVATIVES FOR TREATMENT OF CENTRAL NERVOUS SYSTEMS DISORDERS
    Publication number: 20170022245
    Abstract: The present invention is directed to Ganaxolone prodrugs with increased aqueous solubility and oral bioavailability relative to Ganaxolone and that enable development of stable extended release formulations which offer a significant therapeutic advantage and improved patience compliance by enabling treatments with lower doses over prolonged periods of time.
    Type: Application
    Filed: November 26, 2014
    Publication date: January 26, 2017
    Applicant: BioPharma Works
    Inventors: Robert A Volkmann, Anthony Marfat