Patents by Inventor Anthony Marotta

Anthony Marotta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 14-3-3 eta antibodies and uses thereof for the diagnosis and treatment of arthritis
    Patent number: 12275779
    Abstract: The invention provides anti-14-3-3 eta antibodies that specifically bind to the human 14-3-3 eta protein isoform in its natural configuration while exhibiting selectivity over human 14-3-3 alpha, beta, delta, epsilon, gamma, tau, and zeta protein isoforms. Methods, kits and pharmaceutical compositions comprising said specific anti-14-3-3 eta antibodies are further provided for the diagnosis and treatment of arthritis.
    Type: Grant
    Filed: May 3, 2021
    Date of Patent: April 15, 2025
    Assignee: The University of British Columbia
    Inventor: Anthony Marotta
  • Antigens Derived from Citrullinated 14-3-3 and Uses Thereof in the Diagnosis of Rheumatoid Arthritis
    Publication number: 20250093349
    Abstract: The present invention provides citrullinated 14-3-3? peptides and antibodies thereto and methods of using same to evaluate arthritic conditions such as rheumatoid arthritis.
    Type: Application
    Filed: February 26, 2024
    Publication date: March 20, 2025
    Inventor: Anthony Marotta
  • Antigens derived from citrullinated 14-3-3 and uses thereof in the diagnosis of rheumatoid arthritis
    Patent number: 11913950
    Abstract: The present invention provides citrullinated 14-3-3? peptides and antibodies thereto and methods of using same to evaluate arthritic conditions such as rheumatoid arthritis.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: February 27, 2024
    Inventor: Anthony Marotta
  • 14-3-3 ETA Antibodies and Uses Thereof for the Diagnosis and Treatment of Arthritis
    Publication number: 20220106386
    Abstract: The invention provides anti-14-3-3 eta antibodies that specifically bind to the human 14-3-3 eta protein isoform in its natural configuration while exhibiting selectivity over human 14-3-3 alpha, beta, delta, epsilon, gamma, tau, and zeta protein isoforms. Methods, kits and pharmaceutical compositions comprising said specific anti-14-3-3 eta antibodies are further provided for the diagnosis and treatment of arthritis.
    Type: Application
    Filed: May 3, 2021
    Publication date: April 7, 2022
    Inventor: Anthony MAROTTA
  • COMPOSITIONS AND METHODS FOR CHARACTERIZING ARTHRITIC CONDITIONS
    Publication number: 20210333276
    Abstract: The present invention relates to autoantibodies against 14-3-3 proteins or circulating immune complexes thereof and the detection of such for the diagnosis and prognosis of an arthritic condition.
    Type: Application
    Filed: July 6, 2021
    Publication date: October 28, 2021
    Inventor: Anthony MAROTTA
  • Compositions and methods for characterizing arthritic conditions
    Patent number: 11054419
    Abstract: The present invention relates to autoantibodies against 14-3-3 proteins or circulating immune complexes thereof and the detection of such for the diagnosis and prognosis of an arthritic condition.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: July 6, 2021
    Inventor: Anthony Marotta
  • 14-3-3 eta antibodies and uses thereof for the diagnosis and treatment of arthritis
    Patent number: 10995136
    Abstract: The invention provides anti-14-3-3 eta antibodies that specifically bind to the human 14-3-3 eta protein isoform in its natural configuration while exhibiting selectivity over human 14-3-3 alpha, beta, delta, epsilon, gamma, tau, and zeta protein isoforms. Methods, kits and pharmaceutical compositions comprising said specific anti-14-3-3 eta antibodies are further provided for the diagnosis and treatment of arthritis.
    Type: Grant
    Filed: July 13, 2015
    Date of Patent: May 4, 2021
    Inventor: Anthony Marotta
  • 14-3-3 Antagonists for the Prevention and Treatment of Arthritis
    Publication number: 20200157195
    Abstract: Methods for treating arthritis comprising 14-3-3 antagonists that are capable of specifically binding to extracellularly localized 14-3-3 eta and/or 14-3-3 gamma protein isoforms are provided. In preferred embodiments, the 14-3-3 antagonist is an inhibitory peptide or an anti-14-3-3 antibody. The 14-3-3 antagonists are also formulated in a pharmaceutical compositoin and used in a method for reducing matrix metalloprotease (MMP) expression in the synovial fluid of a patient, wherein the MMP is MMP-1 or MMP-3.
    Type: Application
    Filed: July 31, 2019
    Publication date: May 21, 2020
    Inventors: Anthony MAROTTA, Aziz GHAHARY, Walter Wolodymyr Peter MAKSYMOWYCH, Ruhangiz KILANI
  • Antigens Derived from Citrullinated 14-3-3 and Uses Thereof in the Diagnosis of Rheumatoid Arthritis
    Publication number: 20190310249
    Abstract: The present invention provides citrullinated 14-3-3? peptides and antibodies thereto and methods of using same to evaluate arthritic conditions such as rheumatoid arthritis.
    Type: Application
    Filed: November 19, 2018
    Publication date: October 10, 2019
    Inventor: Anthony Marotta
  • Antigens derived from citrullinated 14-3-3 and uses thereof in the diagnosis of rheumatoid arthritis
    Patent number: 10132806
    Abstract: The present invention provides citrullinated 14-3-3? peptides and antibodies thereto and methods of using same to evaluate arthritic conditions such as rheumatoid arthritis.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: November 20, 2018
    Assignee: AUGUREX LIFE SCIENCES CORP.
    Inventor: Anthony Marotta
  • 14-3-3 Antagonists for the Prevention and Treatment of Arthritis
    Publication number: 20160185842
    Abstract: The invention provides compositions and methods for treating arthritis.
    Type: Application
    Filed: October 1, 2015
    Publication date: June 30, 2016
    Inventors: Anthony MAROTTA, Aziz GHAHARY, Walter Wolodymyr Peter MAKSYMOWYCH, Ruhangiz KILANI
  • 14-3-3 ETA Antibodies and Uses Thereof for the Diagnosis and Treatment of Arthritis
    Publication number: 20160039918
    Abstract: The invention provides anti-14-3-3 eta antibodies that specifically bind to the human 14-3-3 eta protein isoform in its natural configuration while exhibiting selectivity over human 14-3-3 alpha, beta, delta, epsilon, gamma, tau, and zeta protein isoforms. Methods, kits and pharmaceutical compositions comprising said specific anti-14-3-3 eta antibodies are further provided for the diagnosis and treatment of arthritis.
    Type: Application
    Filed: July 13, 2015
    Publication date: February 11, 2016
    Inventor: Anthony MAROTTA
  • 14-3-3 eta antibodies and uses thereof for the diagnosis and treatment of arthritis
    Patent number: 9079947
    Abstract: The invention provides anti-14-3-3 eta antibodies that specifically bind to the human 14-3-3 eta protein isoform in its natural configuration while exhibiting selectivity over human 14-3-3 alpha, beta, delta, epsilon, gamma, tau, and zeta protein isoforms. Methods, kits and pharmaceutical compositions comprising said specific anti-14-3-3 eta antibodies are further provided for the diagnosis and treatment of arthritis.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: July 14, 2015
    Assignee: The University of British Columbia
    Inventor: Anthony Marotta
  • Antigens Derived from Citrullinated 14-3-3 and Uses Thereof in the Diagnosis of Rheumatoid Arthritis
    Publication number: 20140255957
    Abstract: The present invention provides citrullinated 14-3-3? peptides and antibodies thereto and methods of using same to evaluate arthritic conditions such as rheumatoid arthritis.
    Type: Application
    Filed: October 19, 2012
    Publication date: September 11, 2014
    Inventor: Anthony Marotta
  • Compositions and Methods for Characterizing Arthritic Conditions
    Publication number: 20120058498
    Abstract: The present invention relates to autoantibodies against 14-3-3 proteins or circulating immune complexes thereof and the detection of such for the diagnosis and prognosis of an arthritic condition.
    Type: Application
    Filed: March 11, 2010
    Publication date: March 8, 2012
    Inventor: Anthony Marotta