Abstract: This invention relates to comfortable ophthalmic devices and methods of producing such devices.

Abstract: A method for determining a treatment recommendation using a multi-armed bandit (MAB) model can include receiving first patient information, determining, using the MAB model, the treatment recommendation based on the first patient information, wherein the MAB model is trained based on a MAB treatment recommendation determined by the MAB model using second patient information and a clinical treatment recommendation determined according to clinical guidelines based on the second patient information, and providing the treatment recommendation.

Abstract: A storage device write-read error reduction system includes a computing device that includes a storage device. The storage device determines, at a temperature that is within a predefined temperature range, that a storage device background operation should be performed and, in response, identifies data that is stored in the storage device and that was written to the storage device outside the predefined temperature range. The storage device then prioritizes the data that was written to the storage device outside the predefined temperature range over data that was written to the storage device within the predefined temperature range and, based on that prioritization, performs the storage device background operation to rewrite the data to the storage device.

Abstract: A system for interfacing predetermined services to a user at a fixed location includes a processing platform running an operating system. The system further includes a data store for storing configuration information for enabling the operating system to interface with available physical system resources through the physical system resource interface associated therewith. A communication resource for interfacing with the operating system allows communication of the operating system with a central office for downloading configuration information to selectively enable ones of the available physical system resources to interface with the operating system through associated ones of the physical system resource interfaces in accordance with the configuration information and the predetermined service selected by a user. A plurality of configurations is stored in the data store, and each is associated with a predetermined service and one or more of the available physical system resources.

Abstract: Provided herein are methods of treating a subject, such as a subject that has cancer, that include administering a therapeutically effective amount of a STING antagonist or a pharmaceutically acceptable salt, solvate, or co-crystal thereof to a subject identified as having: (I) a cancer cell having one or both of (i) decreased TREX1 level and/or activity, and (ii) increased cGAS/STING signaling pathway activity, e.g., as compared to a reference level, and/or (II) an elevated level of cGAMP in a serum or tumor sample obtained from the subject, e.g., as compared to a reference level.

Abstract: There is a need to dynamically determine one or more levels of difficulty for a computer program associated with one or more levels of difficulty for a computer program associated with one or more dynamic difficulty tasks. In one example, embodiments comprise, during a user interaction session with a computer program, receiving a physiological evaluation data object. One or more physiological difficulty levels may be determined based at least in part on the physiological evaluation data object. One or more program control parameter values for one or more program control parameters may be determined based at least in part on the one or more physiological difficulty levels. User interface data for the computer program may be generated to enable rendering of an in-program experience of the computer program as adjusted by the one or more program control parameter values.

Abstract: This invention relates to comfortable ophthalmic devices and methods of producing such devices.

Abstract: Provided herein are methods of treating a subject, such as a subject that has cancer, that include administering a therapeutically effective amount of a STING antagonist or a cGAS inhibitor or a pharmaceutically acceptable salt, solvate, or co-crystal thereof to a subject identified as having decreased SMARCB1 level and/or activity in a tumor sample obtained from the subject as compared to a reference level.

Abstract: Methods and apparatus for additive manufacture of an article corresponding with an energy transmissibility image. The article may include a contact lens or intraocular lens. The improvements are directed to repeated application of a monomer according to a pattern corresponding with the energy transmissibility image, such as grayscale image. The method may include intermittent pinning of deposited polymerizable mixture, partial cure, and final cure of the deposited polymerizable mixture. A pattern of multiple defined areas may be manufactured, with each area representing an amount of energy transmissibility associated with that area.

Abstract: A device includes a power antenna and a data antenna, along with a switch operable to selectively connect the data antenna to data circuitry under various conditions. For example, the switch may be opened to decouple the data antenna when charging circuitry is receiving power through the power antenna, or under other conditions indicating that charging may be available or desired, thereby allowing for relatively unimpeded and efficient wireless charging of a device. The switch may be closed to enable use of the data antenna by data circuitry when wireless charging activity is not present, or when other conditions indicate that wireless data is available for the device.

Abstract: Provided are systems and methods for producing seamless woven materials that are variable in each of their 3 dimensions. The systems and methods generally operate by altering heddle positions independently to impart three dimensional structure to a woven fabric. Weft yarn is woven into a set of warp yarns that have been individually raised or lowered along a particular cross section, essentially locking the weave into an intended 3 dimensional form.

Abstract: A method and system for identifying scale. The method may include disposing a fluid sampling tool into a wellbore. The fluid sampling tool may comprise at least one probe configured to fluidly connect the fluid sampling tool to a formation in the wellbore and at least one passageway that passes through the at least one probe and into the fluid sampling tool. The method may further comprise drawing a formation fluid, as a fluid sample, through the at least one probe and through the at least one passageway, perturbing the formation fluid, and analyzing the fluid sample in the fluid sampling tool for one or more indications of scale.

Abstract: An anti-cant indicator assembly, components thereof, and associated methods. The anti-cant indicator assembly indicates the orientation of a weapon with respect to vertical. The anti-cant indicator assembly includes a mount configured to mount to the weapon, a level including a vial containing a bubble and a pivot connection connecting the level to the mount. The pivot connection is configured to permit movement of the level with respect to the mount about the pivot connection between an operational position in which the bubble can be referenced by the user for indicating orientation of the weapon with respect to vertical, and a stowed position different from the operational position. The pivot connection can include a retainer configured to releasably retain the level in at least one of the operational position or the stowed position. The level can be selectively movable with respect to the mount to calibrate the anti-cant indicator.

Abstract: An aircraft weight and balance system includes a user interface that displays an interior layout of an aircraft with seat icons and cargo icons corresponding to seats and cargo zones onboard the aircraft. The seat and cargo icons are moveable to different locations within the interior layout, and an updated weight and center-of-gravity of the aircraft is automatically determined based on the different locations of the seat and cargo icons. An aircraft weight and balance method includes displaying an interior layout of an aircraft on a user interface including seat icons corresponding to seats onboard the aircraft, moving one or more of the seat icons to a different location within the interior layout based on a user input, determining an updated weight and center-of-gravity of the aircraft based on a current location of the seat icons, and displaying the updated weight and center-of-gravity of the aircraft on the user interface.

Abstract: A distributed transaction system for enabling users to conduct transactions using services from third party service providers includes a central processing center with one or more communications interfaces to facilitate transactions initiated by users at a plurality of kiosks wherein each of the kiosks includes a user interface enabling a user to access a user selected service and a data store for storing configurations associated with services provided by the third party service providers, whereby a user interfaces with one or more of physical system resources of the kiosk to open a user identity session such that the kiosk is operative to facilitate at least one first user action with the physical resources to initiate a financial transaction and the central processing center is operative to execute at least a second action to facilitate the transaction and to communicate with a financial institution.

Abstract: A storage device projected temperature environment configuration system includes storage devices with the same physical hardware configuration, and a computing device manufacturing system that manufactures computing devices.