Abstract: The present invention features antibodies that have high binding affinity to human neonatal Fc receptor (FcRn). These anti-FcRn antibodies are useful, e.g., to promote clearance of autoantibodies in a subject, to suppress antigen presentation in a subject, to block an immune response, e.g., block an immune complex-based activation of the immune response in a subject, and to treat immunological diseases (e.g., autoimmune diseases) in a subject.

Abstract: A circulation heater is provided which uses a cast body, having resistance heating elements therein and also having spirally wound Teflon tubing wrapped about the heater body. The heater body is formed of cast aluminum or other suitable cast material and after casting is machined to form at least one spiral channel for receiving the heater tube therein. The heater tube is pressed into the tubing channel as the heater tube is progressively wound spirally about the heater body. The channel is formed with an undercut profile wherein the channel is undercut to form a narrower mouth which allows the heater tube to be compressed and then snapped into the channel. The profile of this channel insures direct contact between the tubing and the channel wall over greater than 180 degrees or more than one half of the tube circumference to increase the area of surface contact between the heater tube and channel surface.

Abstract: A circulation heater is provided which uses a cast body, having resistance heating elements therein and also having spirally wound Teflon tubing wrapped about the heater body. The heater body is formed of cast aluminum or other suitable cast material and after casting is machined to form at least one spiral channel for receiving the heater tube therein. The heater tube is pressed into the tubing channel as the heater tube is progressively wound spirally about the heater body. The channel is formed with an undercut profile wherein the channel is undercut to form a narrower mouth which allows the heater tube to be compressed and then snapped into the channel. The profile of this channel insures direct contact between the tubing and the channel wall over greater than 180 degrees or more than one half of the tube circumference to increase the area of surface contact between the heater tube and channel surface.

Abstract: A transaction verification system and method includes a central station coupled to receive transaction data from a plurality of transaction locations at which a person having an account identification document and a mobile communication device that is associated with the account identification document transacts business. If the central station receives a request for a transaction from a location that is consistent with normal usage of the account identification document, the central station approves the transaction. If the central station receives a request for a transaction from a location that is not consistent with normal usage of the account identification document the central station contacts the person through the mobile communication device and approves the transaction only if the person is authenticated using the mobile communication device.