Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: A water irrigation system operative without a master time clock, and in which the valves employed serve as their own Tees in watering individual zones of a field, for a time interval preselected through cam adjustment, and resettable to their initial pre-set positions by spring actuation in response to a decrease in water pressure below a preselected level.