Abstract: An assembly includes an electronic device having depressible controls and a navigation button which is positioned over the electronic device. The navigation button has a central portion, and directional lobes extending from the central portion. The navigation button initially resides in a non-pivoting orientation in which none of the depressible controls are actuated. The navigation button (i) pivots about a first axis in response to depression of a first directional lobe to actuate a first depressible control of the electronic device without actuating a second depressible control of the electronic device, and (ii) pivots about a second axis in response to depression of a second directional lobe to actuate the second depressible control of the electronic device without actuating the first depressible control of the electronic device. Each of the first axis and the second axis is offset from a midpoint of the navigation button.

Abstract: An assembly includes an electronic device having depressible controls and a navigation button which is positioned over the electronic device. The navigation button has a central portion, and directional lobes extending from the central portion. The navigation button initially resides in a non-pivoting orientation in which none of the depressible controls are actuated. The navigation button (i) pivots about a first axis in response to depression of a first directional lobe to actuate a first depressible control of the electronic device without actuating a second depressible control of the electronic device, and (ii) pivots about a second axis in response to depression of a second directional lobe to actuate the second depressible control of the electronic device without actuating the first depressible control of the electronic device. Each of the first axis and the second axis is offset from a midpoint of the navigation button.

Abstract: A novel method for the preparation of a compound of formula (I) from an N—protected-D-mannosamine. A compound of formula (I) is a useful intermediate for the preparation of kiftnensine, a potent and selective mannosidase inhibitor. The method includes protecting the hydroxyl group at the C-6 position of an N—protected-D-mannosamine, to give a 6—O—protected—N—protected-D-mannosamine; reducing the C-1 anomeric carbon atom of the 6—O—protected—N—protected-D-mannosamine to give a 6—O—protected—N—protected-D-mannitol; protecting the four hydroxyl groups of the 6—O—protected—N—protected-D-mannitol; and removing the nitrogen atom protecting group and optionally removing the C-6 oxygen atom protecting group to give the compound of formula (I): where R1 and R2 are each independently protecting groups which, together with the oxygen atoms to which they are attached, form a 5-, 6-, 7- or 8-membered ring; and R3 is hydrogen or a protecting group.

Abstract: A novel method for the preparation of a compound of formula (I) from an N-protected-D-mannosamine. A compound of formula (I) is a useful intermediate for the preparation of kiftnensine, a potent and selective mannosidase inhibitor.