Patents by Inventor Anthony N. Scozzari

Anthony N. Scozzari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of oligonucleotides on solid support
    Patent number: 6822088
    Abstract: The present invention relates to methods for synthesizing an oligomeric compound on a solid support comprising contacting a solid support with a filling material to produce a mixture thereof; placing the mixture in a reaction vessel; and synthesizing the oligomeric compound. The present invention also relates to (a) reaction vessels for synthesizing oligomeric compounds comprising a solid support; and a filling material, (b) apparatuses for synthesizing oligomeric compounds comprising a reagent source, and a reaction vessel comprising a solid support; and a filling material, and (c) compositions comprising a solid support and a filling material mixed therewith.
    Type: Grant
    Filed: July 16, 2002
    Date of Patent: November 23, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Max Moore, Achim H. Krotz, Mark Andrade, Anthony N. Scozzari
  • Methods for removing dimethoxytrityl groups from oligonucleotides
    Patent number: 6794502
    Abstract: The present invention discloses improved methods for oligonucleotide synthesis and purification. In the methods of the invention, a half-life is determined for deprotection of the 5′-OH protecting group at the 5′-terminus of an oligonucleotide post-synthesis. The half-life is used to determine an optimal reaction time for removal of the 5′-OH protecting group. The methods of the invention are amenable to the large-scale synthesis and purification of oligonucleotides.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: September 21, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Achim H. Krotz, Bethany M. McElroy, Anthony N. Scozzari
  • Processes of purifying oligonucleotides
    Patent number: 6632938
    Abstract: Methods for preparing purified oligonucleotides by treating a solution comprising an oligonucleotide with an aggregating agent and a precipitation enhancer under conditions sufficient to form an oligonucleotide aggregate and isolating the oligonucleotide aggregate to produce a purified oligonucleotide.
    Type: Grant
    Filed: June 7, 2001
    Date of Patent: October 14, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Max N. Moore, John Charles Arthur, Kent Vansooy, Anthony N. Scozzari
  • Processes of purifying oligonucleotides
    Publication number: 20030055241
    Abstract: Methods for preparing purified oligonucleotides by treating a solution comprising an oligonucleotide with an aggregating agent and a precipitation enhancer under conditions sufficient to form an oligonucleotide aggregate and isolating the oligonucleotide aggregate to produce a purified oligonucleotide.
    Type: Application
    Filed: June 7, 2001
    Publication date: March 20, 2003
    Inventors: Max N. Moore, John Charles Arthur, Kent Vansooy, Anthony N. Scozzari
  • Synthesis of oligonucleotides on solid support
    Publication number: 20030032795
    Abstract: The present invention relates to methods for synthesizing an oligomeric compound on a solid support comprising contacting a solid support with a filling material to produce a mixture thereof; placing the mixture in a reaction vessel; and synthesizing the oligomeric compound. The present invention also relates to (a) reaction vessels for synthesizing oligomeric compounds comprising a solid support; and a filling material, (b) apparatuses for synthesizing oligomeric compounds comprising a reagent source, and a reaction vessel comprising a solid support; and a filling material, and (c) compositions comprising a solid support and a filling material mixed therewith.
    Type: Application
    Filed: July 16, 2002
    Publication date: February 13, 2003
    Inventors: Max Moore, Achim H. Krotz, Mark Andrade, Anthony N. Scozzari
  • Methods for removing dimethoxytrityl groups from oligonucleotides
    Publication number: 20020156268
    Abstract: The present invention discloses improved methods for oligonucleotide synthesis and purification. In the methods of the invention, a half-life is determined for deprotection of the 5′-OH protecting group at the 5′-terminus of an oligonucleotide post-synthesis. The half-life is used to determine an optimal reaction time for removal of the 5′-OH protecting group. The methods of the invention are amenable to the large-scale synthesis and purification of oligonucleotides.
    Type: Application
    Filed: March 22, 2002
    Publication date: October 24, 2002
    Inventors: Achim H. Krotz, Bethany M. McElroy, Anthony N. Scozzari
  • Methods for removing dimethoxytrityl groups from oligonucleotides
    Patent number: 6399765
    Abstract: The present invention discloses improved methods for oligonucleotide synthesis and purification. In the methods of the invention, a half-life is determined for deprotection of the 5′-OH protecting group at the 5′-terminus of an oligonucleotide post-synthesis. The half-life is used to determine an optimal reaction time for removal of the 5′-OH protecting group. The methods of the invention are amenable to the large-scale synthesis and purification of oligonucleotides.
    Type: Grant
    Filed: March 17, 1999
    Date of Patent: June 4, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Achim H. Krotz, Bethany M. McElroy, Anthony N. Scozzari