Abstract: Methods and pharmaceutical compositions for treating malaria and immune related disorders are provided. The pharmaceutical compositions include an effective amount a carmaphycin B analog that inhibits immunoproteasome activity in a subject.

Abstract: The present disclosure relates generally to detection of contamination of a sample or diagnosis of subject based upon detection or quantification of amino acid sequences in a sample, specifically to the identification and use of molecular biomarkers for Candida albicans biofilm infections.

Abstract: A system includes a bandgap voltage generator coupled to a voltage supply and configured to produce a plurality of reference voltage levels in response to a plurality of calibration codes; an analog-to-digital converter (ADC) coupled to a reference voltage output of the bandgap voltage generator; a logic circuit coupled to an output of the ADC; a first memory element coupled to the logic circuit and configured to store a calibration coefficient indicative of a relationship of the calibration codes and the reference voltage levels; and a second memory element coupled to the logic circuit and configured to store a value of a first reference voltage level for the reference voltage output, wherein the logic circuit is configured to generate a first calibration code from the value of the first reference voltage level and the calibration coefficient.

Abstract: Methods and devices are described for controlling excess loop delay (ELD) gain compensation in a digital-to-analog converter (DAC) of a successive approximation register (SAR) analog-to-digital converter (ADC) by using DAC unit elements in the ELD DAC and DACs for the SAR ADC efficiently. The ELD DAC and DAC partially share DAC units (e.g. capacitors or current sources) to minimize total DAC units used to limit area and power usage while maintaining operational flexibility. Different configurations provide ELD gains of less than or greater than one. A dedicated sampling capacitor is also provided to allow flexible gain control by capacitance ratio.

Abstract: Methods and pharmaceutical compositions for treating malaria and immune related disorders are provided. The pharmaceutical compositions include an effective amount a carmaphycin B analog that inhibits immunoproteasome activity in a subject.

Abstract: The present disclosure relates generally to detection of contamination of a sample or diagnosis of subject based upon detection or quantification of amino acid sequences in a sample, specifically to the identification and use of molecular biomarkers for Candida albicans biofilm infections.

Abstract: A user interface method for user selected zoom level determination. The method includes displaying a page of a document on a screen of the handheld device, and receiving an input from a user of the handheld device and setting a zoom level of the page in accordance there with. The method further includes, in response to the zoom level, processing the page in accordance there with to produce a plurality of dynamically sized segments, and for displaying successive pages on the screen, processing the successive pages to produce additional dynamically sized segments in accordance with the zoom level.

Abstract: A latency associated with a receiver circuit, e.g., radio receiver circuit, can be reduced by applying digital data from an analog signal received by a receiver, e.g., a radio receiver, to an automatic gain control circuit without first using a decimation and digital filtering process, which can minimize or eliminate significant latency associated with the decimation and filtering process.

Abstract: Content is displayed on a touchscreen display of a computing system such as an electronic book reader. The content is displayed according to a setting for a first attribute (e.g., level of brightness) and a setting for a second attribute (e.g., day mode or night mode). In response to sensing a motion proximate to the touchscreen, the setting for the first attribute is changed to a different value. In response to a value for the setting for the first attribute crossing a threshold value (e.g., while the motion is being performed), the setting for the second attribute is changed.

Abstract: A system and method for automatically generating a commodity introductory document that encompasses personalized subject matter as well as related information acquired from external information sources. A predetermined template comprising user-authored sections and automated sections is used to select and organize the information. The GUIs corresponding to the user-authored sections allow an introductory document author to provide personalized input. The automated sections are linked to information sources through embedded hyperlinks, from which relevant information can be identified and derived to populate the automated sections. The introductory document author may be provided with a few options regarding the layout and the presentation of the indicatory document as well as individual sections thereof.

Abstract: Examples described herein include a computing system or environment that enables the user to acquire an option to re-transfer a purchased digital content item at a later date. Data corresponding to the option can be recorded and linked with the user. Subsequent requests from the user to re-transfer the digital content item can be permitted or denied based on whether the user is authorized by way of having acquired the corresponding option.

Abstract: A computing device operates to receive a current issue of an electronic periodical. In response to receiving the current issue, the computing device performs one or more actions to remove at least the content portion of at least one prior issue of the electronic periodical that was download on the computing device. Metadata content is displayed to represent a collection of issues for the electronic periodical that were acquired for download for an account associated with the computing device. The collection of issues includes the current issue and at least one prior issue the electronic periodical. The metadata content that is displayed to represent the collection can be based at least in part on a metadata portion of the current issue.

Abstract: System and method of publishing a personal collection of electronic books responsive to a user request. A graphical user interface (GUI) is configured to allow a user to compile a collection of electronic books and then request to share the collection to other users of a select website. In response to the request, a personal collection webpage is automatically generated and made accessible to the public users of the website through a hyperlink. The public users may submit subscribing requests through the webpage for receiving update notifications. The creator-user of a published personal collection may receive an incentive based on the number of subscribers of the collection, and the volume of books included in the collection and purchased by the subscribers.

Abstract: System and method for bookmark a select location with a page of an ebook. A graphical user interface (GUI) is configured to display content of a page, and bookmark a select location within the page responsive to a swipe gesture starting from a predetermined position on the GUI. The end position of swipe gesture is recorded as the bookmark and a visual object representing the bookmark is rendered on the GUI. The select location may correspond to a last line that a user just finished reading before closing the reading session of the electronic document. The visual object may be removed from the electronic document once a user can locate the select location in a subsequent reading session.

Abstract: Content is displayed on a touchscreen display of a computing system such as an electronic book reader. The content is displayed according to a setting for a first attribute (e.g., level of brightness) and a setting for a second attribute (e.g., day mode or night mode). In response to sensing a motion proximate to the touchscreen, the setting for the first attribute is changed to a different value. In response to a value for the setting for the first attribute crossing a threshold value (e.g., while the motion is being performed), the setting for the second attribute is changed.

Abstract: System and method for presenting a customized aggregation of information based on specific state-of-mind of a user. An end-of-book experience graphical user interface (GUI) is configured to capture a specific state-of-mind of a user by using an options menu listing typical state-of-minds of typical book users. Provided the user indicates to expand reading experience on the instant book, a set of information that facilitates a deep dive experience on the instant book can be presented. Alternatively, provided the user indicates to move on from the instant book, a collection of books of in different categories from the instant can be recommended. The end-of-book experience GUI can be prompted upon a user indication of having finished reading a book, closing the reading program before finishing, or re-reading the book.

Abstract: An electronic library can include book titles that the user owns, such as downloaded or archived e-books that are purchased from a network service, and book titles that the user has identified as having been read. In this way, the user's library can reflect the book titles that the user has previously read even though the user does not own or have right to possess a corresponding e-book.

Abstract: A system and method for facilitating creation of and access to public annotations of electronic publications. A graphical user interface (GUI) is configured to display content of the electronic publication as well as annotations pertaining to the content of the electronic publication. Available annotations of the electronic publication may be downloaded to an electronic reading device through network from a remote server. The remote server may send notifications upon new annotations are available for a book. The GUI may also be configured to receive an annotation entry input by a user through the electronic reading device.

Abstract: A user interface method for textually biased flow. The method includes displaying a section of an article of a document on a screen of the handheld device, and receiving an input from a user of the handheld device. The method further includes interpreting the input as an intention to change and to render a different section of the article, and rendering the different section of the article without interruption from an intervening section not related to the article.

Abstract: A user interface method for dynamic guided reading. The method includes displaying a section of a document on a screen of the handheld device, and receiving an input from a user of the handheld device. The method further includes interpreting the input as an intention to read the section of the document, in response to the intention to read the section of the document, displaying a guided reading confirmation region on a section of the screen of the handheld device, and upon receiving a user input on the confirmation region, enabling guided reading on the handheld device.