Patents by Inventor Anthony O. Ragheb
Anthony O. Ragheb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20040073284Abstract: A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon. The medical device is preferably an implantable stent or balloon (26) of which the bioactive material layer is deposited thereon. The stent can be positioned around the balloon and another layer of the bioactive material posited over the entire structure and extending beyond the ends of the positioned stent. The ends of the balloon extend beyond the ends of the stent and include the bioactive material thereon for delivering the bioactive material to the cells of a vessel wall coming in contact therewith. The balloon further includes a layer of hydrophilic material (58) positioned between the base and bioactive material layers of the balloon.Type: ApplicationFiled: July 14, 2003Publication date: April 15, 2004Applicants: Cook Incorporated, MED Institute, Inc., WILLIAM COOK EUROPE ApSInventors: Brian L. Bates, Scott E. Boatman, David G. Burton, Michael C. Hoffa, Darin G. Schaeffer, Jason S. Sturgeon, Anthony O. Ragheb
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Publication number: 20040047909Abstract: Methods of making coated implantable medical devices are provided. The methods include positioning a first layer comprising a bioactive on at least a portion of a structure, and positioning at least one porous layer over the first layer. The at least one porous layer has a thickness adequate to provide a controlled release of the bioactive.Type: ApplicationFiled: April 14, 2003Publication date: March 11, 2004Inventors: Anthony O. Ragheb, Neal E. Fearnot, William D. Voorhees, Thomas G. Kozma, Brian L. Bates, Thomas A. Osborne
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Patent number: 6530951Abstract: A silver implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material posited on one surface of structure 12; and at least one porous layer 20 posited over the bioactive material layer 18 posited on one surface of structure 12 and the bioactive-material-free surface. Also included is a layer or impregnation of silver 45. Preferably, the structure 12 is a coronary stent. The porous layer 20 is comprised of a polymer applied preferably by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor. Silver is included as a base material, coating or included in a carrier, drug, medicament material utilized with the implantable stent.Type: GrantFiled: October 23, 1997Date of Patent: March 11, 2003Assignees: Cook Incorporated, MED Institute Inc.Inventors: Brian L. Bates, Neal E. Fearnot, Thomas G. Kozma, Thomas A. Osborne, Anthony O. Ragheb, Joseph W. Roberts, William D. Voorhees, III
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Publication number: 20030036794Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract, and at least one layer 18 of an immunosuppressive agent posited over at least one surface of the structure 12. Optionally, the device 10 can include at least one porous, preferably polymeric layer 20 posited over the layer 18 of immunosuppressive agent, and can alternatively or additionally include at least one coating layer 16 posited on one surface of the structure 12, the at least one layer 18 of immunosuppessive agent being posited in turn on at least a portion of the coating layer 16. The porous layer 20 and the coating layer 16 each provide for the controlled release of the bioactive material from the device 10. The structure 12 is preferably configured as a coronary stent. The polymer of the porous layer 20 is preferably applied by vapor or plasma deposition.Type: ApplicationFiled: August 19, 2002Publication date: February 20, 2003Applicant: Cook IncorporatedInventors: Anthony O. Ragheb, Neal E. Fearnot, William D. Voorhees, Thomas G. Kozma, Brian L. Bates, Thomas A. Osborne
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Publication number: 20030028244Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.Type: ApplicationFiled: August 14, 2002Publication date: February 6, 2003Applicant: Cook IncorporatedInventors: Brian L. Bates, Anthony O. Ragheb, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees
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Publication number: 20030028243Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.Type: ApplicationFiled: August 14, 2002Publication date: February 6, 2003Applicant: Cook IncorporatedInventors: Brian L. Bates, Anthony O. Ragheb, Neal E. Fearnot, William D. Voorhees, Thomas G. Kozma
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Publication number: 20020193828Abstract: Endovascular filter (10) including a plurality of struts (14) with distal ends (18) adapted to anchor the filter to the vessel wall after deployment, such as by having barbs (20), the filter being adapted to be retrieved if desired. Strut distal ends (18) are coated with an antiproliferative agent (40) that inhibits the ingrowth of tissue around the filter, thereby permitting the filter to be retrieved and removed atraumatically after a prolonged period of time, thus extending the useful life of the retrievable filter. Optionally, the proximal end (22) of the filter may also be so coated, or the entire filter.Type: ApplicationFiled: June 14, 2002Publication date: December 19, 2002Applicant: COOK INCORPORATEDInventors: Dennis Griffin, Arne Molgaard-Nielsen, Anthony O. Ragheb, Raymond B. Leonard
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Publication number: 20020098278Abstract: A medical device (10) includes a structure (12) adapted for introduction into a patient, the structure (12) being formed of a preferably non-porous base material (14) having a roughened or textured surface (16). The structure (12) is conveniently configured as a vascular stent with a base material (14) of stainless steel, nitinol or another suitable material. The medical device (10) also includes a layer (18) of a bioactive material posited directly upon the roughened or textured surface (16) of the base material (14) of the structure (12). The surface (16) of the base material (14) is roughened or textured by etching or by abrasion with sodium bicarbonate or another suitable grit. A preferred roughened or textured surface (16) is thought to have a mean surface roughness of about 10 &mgr;in. (about 250 nm) and a surface roughness range between about 1 &mgr;in. and about 100 &mgr;in. (about 25 nm and about 2.5 &mgr;m).Type: ApplicationFiled: October 31, 2001Publication date: July 25, 2002Applicant: Cook IncorporatedInventors: Brian L. Bates, Anthony O. Ragheb, Joseph M. Stewart, William J. Bourdeau, Brian D. Choules, James D. Purdy, Neal E. Fearnot
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Publication number: 20020032414Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer is includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.Type: ApplicationFiled: May 7, 2001Publication date: March 14, 2002Inventors: Anthony O. Ragheb, Brian L. Bates, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees
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Patent number: 6299604Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer is includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material.Type: GrantFiled: August 20, 1999Date of Patent: October 9, 2001Assignees: Cook Incorporated, MED Institute Inc.Inventors: Anthony O. Ragheb, Brian L. Bates, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III
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Patent number: 6096070Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material posited on one surface of structure 12; and at least one porous layer 20 posited over the bioactive material layer 18 posited on one surface of structure (12) and the bioactive-material-free surface. Preferably, the structure 12 is a coronary stent. The porous layer 20 is comprised of a polymer applied preferably by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor. Also disclosed is the method of manufacture of the device 10, as well as a method of using it in medical treatments.Type: GrantFiled: May 16, 1996Date of Patent: August 1, 2000Assignees: MED Institute Inc., Cook Inc.Inventors: Anthony O. Ragheb, Brian L. Bates, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III
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Patent number: 5873904Abstract: A silver implantable medical device 29 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material posited on one surface of structure 12; and at least one porous layer 20 posited over the bioactive material layer 18 posited on one surface of structure (12) and the bioactive-material-free surface. Also included is a layer or impregnation of silver 45. Preferably, the structure 12 is a coronary stent. The porous layer 20 is comprised of a polymer applied preferably by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor. Silver is included as a base material, coating or included in a carrier, drug, medicant material utilized with the implantable stent.Type: GrantFiled: February 24, 1997Date of Patent: February 23, 1999Assignees: Cook Incorporated, MED Institute, Inc.Inventors: Anthony O. Ragheb, Brian L. Bates, Neal E. Fearnot, Thomas A. Osborne, Thomas G. Kozma, Joseph W. Roberts, William D. Voorhees, III
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Patent number: 5824049Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material posited on one surface of structure 12; and at least one porous layer 20 posited over the bioactive material layer 18 posited on one surface of structure (12) and the bioactive-material-free surface. Preferably, the structure 12 is a coronary stent. The porous layer 20 is comprised of a polymer applied preferably by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor. Also disclosed is the method of manufacture of the device 10, as well as a method of using it in medical treatments.Type: GrantFiled: October 31, 1996Date of Patent: October 20, 1998Assignee: MED Institute, Inc.Inventors: Anthony O. Ragheb, Brian L. Bates, Neal E. Fearnot, Thomas G. Kozma, William D. Voorhees, III
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Patent number: 5609629Abstract: A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material positioned over the structure 12; and at least one porous layer 20 positioned over the bioactive material layer 18. Preferably, the structure 12 is a coronary stent, and the bioactive material is at least one of heparin, dexamethasone or a dexamethasone derivative. The device 10 includes layers 18 and 22 of heparin and dexamethasone, the layer 22 of dexamethasone being positioned above the layer 18 of heparin. The layers of bioactive material also can be individual materials or a combination of different materials. Unexpectedly, the more soluble heparin markedly promotes the release of the less soluble dexamethasone above it. The porous layer 20 is composed of a polymer applied by vapor or plasma deposition and provides a controlled release of the bioactive material.Type: GrantFiled: June 7, 1995Date of Patent: March 11, 1997Assignee: MED Institute, Inc.Inventors: Neal E. Fearnot, Thomas G. Kozma, Anthony O. Ragheb, William D. Voorhees
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Patent number: 5380299Abstract: An intravascular medical device having a structure shaped and sized for introduction into the vascular system of a patient including a base material and a coating of a thrombolytic agent on the base material. The thrombolytic agent advantageously dissolves or breaks up the formation of thrombus on the surface of the structure when placed in the vascular system of a patient. The intravascular medical device also includes a antithrombogenic agent for inhibiting the formation of thrombus on the surface of the medical device. The method of treating a medical device with a thrombolytic agent includes providing a base material for the medical device along with a thrombolytic agent. The base material is dipped into the thrombolytic agent and then removed to allow the thrombolytic agent to dry on the surface thereof. The dipping and drying steps are repeated to increase the concentration or quantity of the thrombolytic agent on the device.Type: GrantFiled: August 30, 1993Date of Patent: January 10, 1995Assignee: MED Institute, Inc.Inventors: Neal E. Fearnot, Anthony O. Ragheb, William D. Voorhees, III