Abstract: An SPR detection apparatus has an optical system with a sensor member including a planar metallic layer, the sensor member being removably mountable to a housing. First optics direct an incident beam toward a rear side of the metallic layer at a predetermined range of angles to a normal to the sensor layer. Second optics guide at least one reflected beam, corresponding to the incident beam, from the metallic layer to the transducer. The transducer converts incoming electromagnetic radiation to an electrical signal for transmission to a signal processor disposed in the housing and operatively connected to the at least one opto-electrical transducer so as to detect a surface plasmon resonance angle. The first optics are configured so that the at least one incident beam spans at least about 20°.

Abstract: An SPR detection apparatus has an optical system with a sensor member including a planar metallic layer, the sensor member being removably mountable to a housing. First optics direct an incident beam toward a rear side of the metallic layer at a predetermined range of angles to a normal to the sensor layer. Second optics guide at least one reflected beam, corresponding to the incident beam, from the metallic layer to the transducer. The transducer converts incoming electromagnetic radiation to an electrical signal for transmission to a signal processor disposed in the housing and operatively connected to the at least one opto-electrical transducer so as to detect a surface plasmon resonance angle. The first optics are configured so that the at least one incident beam spans at least about 20°.

Abstract: A medical diagnostic method utilizes a surface plasmon resonance apparatus provided with a sensing surface. A tear sample from an eye of a patient is placed into contact with the sensing surface. The surface plasmon resonance apparatus is then operated to determine concentrations of solutes such as salt and antigenic analytes in the tear sample.

Abstract: A medical diagnostic method utilizes a surface plasmon resonance apparatus provided with a sensing surface. A tear sample from an eye of a patient is placed into contact with the sensing surface. The surface plasmon resonance apparatus is then operated to determine concentrations of solutes such as salt and antigenic analytes in the tear sample.

Abstract: A medical diagnostic method utilizes a surface plasmon resonance apparatus provided with a sensing surface. A tear sample from an eye of a patient is placed into contact with the sensing surface. The surface plasmon resonance apparatus is then operated to determine osmolarity of the tear sample.

Abstract: In a method for testing the visual field of a patient especially the central visual field, stereoscopic or binocularly displaced fixation images are presented under computer control to the respective eyes of the patient. In addition, a series of test images viewable by only one of the patient's eyes is generated under the control of the computer. The fixation images, one for each eye, are presented on two separate electronic displays, while the test images may be produced on a third display member different from the electronic displays. The computer is programmed to precisely determine a boundary between points corresponding to unseen test images and points corresponding to seen test images, by automatically testing additional points in a region located about the curve and between points corresponding to unseen test images and points corresponding to seen test images.

Abstract: In a method for testing the visual field of a patient especially the central visual field, stereoscopic or binocularly displaced fixation images are presented under computer control to the respective eyes of the patient. In addition, a series of test images viewable by only one of the patient's eyes is generated under the control of the computer. The fixation images, one for each eye, are presented on two separate electronic displays, while the test images may be produced on a third display member different from the electronic displays. The computer is programmed to precisely determine a boundary between points corresponding to unseen test images and points corresponding to seen test images, by automatically testing additional points in a region located about the curve and between points corresponding to unseen test images and points corresponding to seen test images.

Abstract: An apparatus for illuminating a portion of a patient's body includes an enclosure having a generally smoothly curved shape, an internal light-scattering surface, and an opening. A light source provides light to a portion of the light-scattering surface within the enclosure so as to illuminate the surface via scattering of the light on the surface. An at least partially transparent member is positioned within the enclosure so that scattered light passes through it and through the opening.

Abstract: An ophthalmic apparatus has instrumentation for performing an ophthalmic procedure on a patient's eye when the patient and the instrumentation are aligned with each other with respect to orthogonal X, Y, and Z axes. The Z axis specifies the distance of the eye from the instrumentation. A signal generator generates an initiation signal to initiate alignment of the instrumentation and the eye. An X-Y alignment apparatus and a Z alignment apparatus each respond to the initiation signal to cause alignment along their respective axes and then determine when the instrumentation and the eye are in predetermined relative positions along the Z axis. The X-Y alignment apparatus and the Z alignment apparatus each generate a respective alignment signal. A controller receives the Z alignment signal and the X-Y alignment signal and issues a control signal to the instrumentation to perform an ophthalmic procedure in response to the alignment signals.