Abstract: The present invention relates to synthetic polypeptide compounds which bind to a class A G-protein-coupled receptor, the Apelin receptor. These compounds may act as apelin receptor antagonists. These compounds and compositions comprising them may be useful in the treatment of diseases, such as cancer.

Abstract: An implant system for implantation at a joint. The implant system includes an implant device with a body portion having first and second ends, and a first elongate member, extending from the first or second end of the body portion. The implant system has a corresponding fixation device with at least one latching element. The first elongate member has at least one cooperating element capable of cooperating with the at least one latching element of the fixation device in use.

Abstract: Implementations of the present disclosure may include systems and methods for providing an improved bingo game based on player defined custom bingo cards and mapping the player defined custom bingo cards to simulate other games, such as, but not limited to, wheel based games such as roulette, dice games, and other suitable games. Implementations of the system and method may include receiving messages comprising one or more player wager selections from the plurality of electronic player interfaces, wherein the one or more player wager selections comprise one or more player selected game patterns. Implementations of the system and method may include creating one or more custom bingo cards based on the one or more player selected game patterns received in the one or more player wager selections.

Abstract: Implementations of the present disclosure may include systems and methods for providing an improved bingo game based on player defined custom bingo cards and mapping the player defined custom bingo cards to simulate other games, such as, but not limited to, wheel based games such as roulette, dice games, and other suitable games. Implementations of the system and method may include receiving messages comprising one or more player wager selections from the plurality of electronic player interfaces, wherein the one or more player wager selections comprise one or more player selected game patterns. Implementations of the system and method may include creating one or more custom bingo cards based on the one or more player selected game patterns received in the one or more player wager selections.

Abstract: Methods and system for identifying individual materials from waste streams are disclosed. A request can be received from a requester to assess waste within a waste container. Media in the form at least one of still images or video streams can be accessed from at least one camera located in association with a waste container. The media can be transmitted to an artificial intelligence (AI) platform for processing to determine the class of individual materials contained in the media and provide identification with a confidence level. A data file containing processing results can be created. A response can be generated and transmitted to the requester that initiated the request. The response can include data that further includes all materials found by the AI platform as contained in the media with a confidence level for each and at least one of an identification of the requester, container identification, and container location.

Abstract: A method of producing vehicles comprises: in a vehicle production process, manufacturing vehicle components of different types, and assembling the vehicle components to form vehicles; creating a set of vehicle records, each being a record of one of the vehicles entering active service; performing vehicle repairs on a subset of the vehicles after they have entered active service; creating a respective record of each of the vehicle repairs, each of which comprises or indicates a vehicle age or usage value, and records a vehicle component fault identified in the vehicle repair; receiving at a data processing stage the vehicle records and vehicle repair records, wherein a predictive algorithm executed at the data processing stage processes the received records so as to, for each type of vehicle component: 1) identify a respective set of the vehicle repair records relating to that type of vehicle component, and 2) use the respective set of vehicle repair records to predict a respective number of or resource value

Abstract: A security document with a first security element, which includes a first item of visually recognizable and in particular machine-readable information, and a second security element, which includes a second item of in particular machine-readable information which can be used to verify the first item of information. A method for the authentication thereof is also described.

Abstract: The present invention relates to macrocyclic compounds which are capable of selective binding to a target saccharide (e.g. glucose), making them particularly well suited for use in saccharide sensing applications. The present invention also relates to processes for the preparation of said compounds, to compositions and devices comprising them, and to their use in the detection of a target saccharide.

Abstract: A testing apparatus for performing an assay, the testing apparatus comprising: a receptacle (2) containing a reagent, the reagent being reactive to an applied test sample by developing a colour or pattern variation; a portable device (1), e.g. a mobile phone or a laptop, comprising a processor and an image capture device (3), wherein the processor is configured to process data captured by the image capture device and output a test result for the applied test sample.

Abstract: Implementations of the present disclosure may include systems and methods for providing an improved bingo game based on player defined custom bingo cards and mapping the player defined custom bingo cards to simulate other games, such as, but not limited to, wheel based games such as roulette, dice games, and other suitable games. Implementations of the system and method may include receiving messages comprising one or more player wager selections from the plurality of electronic player interfaces, wherein the one or more player wager selections comprise one or more player selected game patterns. Implementations of the system and method may include creating one or more custom bingo cards based on the one or more player selected game patterns received in the one or more player wager selections.

Abstract: An adaptive user authentication system is disclosed that executes user authentication by verifying user identity using different authentication steps based on a risk score. The risk score enables determining if the requesting user's identity is to be verified. If it is determined that the user identity is to be verified, a sequence of authentication steps is implemented wherein more and more data is collected regarding the user as the user fails to be authenticated at each of the authentication steps. A first authentication step includes a numerical-based authentication step followed by a second authentication step including a live image authentication. If the user fails to be authenticated at either the first or the second authentication steps then a third authentication step to verify the user's passport is implemented.

Abstract: The present invention provides glucose sensitive insulin derivatives comprising a macrocycle, a glucose mimetic and human insulin or an analogue thereof, and their pharmaceutical use. Furthermore, the invention relates to pharmaceutical compositions comprising such glucose sensitive insulin derivatives, and to the use of such compounds for the treatment or prevention of medical conditions relating to diabetes.

Abstract: Provided are populations of cells enriched for MSC-derived cells that are: CD90+; CD105+; CD45?; as well as TIMP-1 secretion high, and MMP13 gene expression low. Such populations of cells are useful as medicaments in contexts where it is desired to make use of the trophic or immunosuppressive therapeutic effects of MSCs, but to avoid activity associated with the capacity of MSCs to undergo phenotypic differentiation. Populations of cells of the invention are useful in the treatment of a condition selected from the group consisting of: osteoarthritis; myocardial infarction; meniscus cartilage injury (such as torn meniscus); ligament injury (such as torn ligament); injuries to the skin; and soft tissue injury. They may also be used in treatment of a disease selected from the group consisting of: haematological disease; graft-versus-host disease; and inflammatory disease.

Abstract: A method of estimating network latency including receiving intercept data (representing observations of requests sent by a client node and responses to the respective requests from a host node), detecting a burst of network traffic bounded by a first idle interval and/or second idle interval, and estimating download and/or upload latencies associated with the burst, wherein the download latency is estimated to be an amount of time between observation of an inferred first request of the burst from the client node until observation of a first response from the host node following the inferred first request, and the upload latency is estimated to be an amount of time between observation of a last inferred data packet of the burst from the host node to the client node until observation of a last inferred ACK packet from the client node following the last inferred data packet from the host node.

Abstract: The technology disclosed herein enables ambient noise level determination at an endpoint using a secondary audio capture system for the endpoint. In a particular embodiment, a method includes during a communication session, receiving an audio signal representing sound captured by a secondary audio capture system for an endpoint on the communication session. A primary audio capture system for the endpoint captures voice communications from a user of the endpoint for the communication session. The method further determining an ambient noise level for the endpoint from the audio signal and, in response to determining that the ambient noise level satisfies a loudness criterion, presenting a notification to the user about the ambient noise level.

Abstract: A method of estimating network latency including receiving intercept data (representing observations of requests sent by a client node and responses to the respective requests from a host node), detecting a burst of network traffic bounded by a first idle interval and/or second idle interval, and estimating download and/or upload latencies associated with the burst, wherein the download latency is estimated to be an amount of time between observation of an inferred first request of the burst from the client node until observation of a first response from the host node following the inferred first request, and the upload latency is estimated to be an amount of time between observation of a last inferred data packet of the burst from the host node to the client node until observation of a last inferred ACK packet from the client node following the last inferred data packet from the host node.

Abstract: An acquired image is analysed to determine a test outcome value. A shape template for a test structure is provided to identify a position of a target measurement region on the test structure. A mapping defining a transformation of the shape template onto the image frame is determined. A mapping is determined and it is determined if a first matching condition based on first displacements of one or more edges identified in the image frame relative to the shape template is satisfied for the mapping. When the mapping satisfies the first matching condition and a second different matching condition based on second displacements of one or more edges identified in the image frame relative to the shape template, a verified image of a test structure is established. In the verified image of the test structure a target measurement region is identified. A test outcome value is determined by analysing the target measurement region.

Abstract: The technology disclosed herein enables ambient noise level determination at an endpoint using a secondary audio capture system for the endpoint. In a particular embodiment, a method includes during a communication session, receiving an audio signal representing sound captured by a secondary audio capture system for an endpoint on the communication session. A primary audio capture system for the endpoint captures voice communications from a user of the endpoint for the communication session. The method further determining an ambient noise level for the endpoint from the audio signal and, in response to determining that the ambient noise level satisfies a loudness criterion, presenting a notification to the user about the ambient noise level.

Abstract: The present invention provides glucose sensitive insulin derivatives comprising a macrocycle, a glucose mimetic and human insulin or an analogue thereof, and their pharmaceutical use. Furthermore, the invention relates to pharmaceutical compositions comprising such glucose sensitive insulin derivatives, and to the use of such compounds for the treatment or prevention of medical conditions relating to diabetes.

Abstract: A location-based risk alerting system is disclosed. When information regarding a risk assessment situation is received, the location and time attributes of the risk assessment situation are extracted, a risk score is calculated and a risk alert is generated to include the attributes and the risk score upon validating the received information for risk. The risk alert is transmitted to client devices of subscribers where a user-specific risk score is calculated at each client device based on a comparison of the distance of the client device from the location attribute and the time at which the risk alert is received with the time attribute. The risk alert is displayed at the client device based on the user-specific risk score and information regarding the user is shared with trusted authorities upon receiving user consent.