Abstract: Disclosed herein are engineered oligonucleotides for selective inhibition of polypeptide expression and activity. Also disclosed herein are methods of selectively inhibiting polypeptide expression and activity contacting an engineered oligonucleotide with a polynucleotide encoding the polypeptide.

Abstract: Disclosed herein are engineered DUX4-targeting oligonucleotides for selective inhibition of RNA transcripts associated with a neuromuscular disease such as facioscapulohumeral muscular dystrophy. Also disclosed are vectors containing any of these, pharmaceutical formulations containing any of the these, and kits containing any of the these. Also disclosed herein are methods of selectively inhibiting polypeptide expression and activity by contacting a DUX4-targeting oligonucleotide with an RNA transcript associated with a neuromuscular disease such as facioscapulohumeral muscular dystrophy.

Abstract: An accelerated network security system includes, in part, a network security engine and a processing module configured to perform network security functions. The network security engine includes an input module configured to receive input data and generate an intermediate data in response, a core engine configured to perform security function operations on the first intermediate data to generate a first output data, and an output module configured to receive the first output data and generate a processed output data in response. The processing module includes a multitude of processing cores configured to operate concurrently, a memory configured to store processing core instructions and processing core data associated with the multitude of processing cores, and a processing controller configured to periodically allocate to each processing core one or more discrete blocks of processing time. The number of processing core data is greater than the number of processing cores.

Abstract: An accelerated network intrusion detection and prevention system includes, in part, first, second and third processing stages. The first processing stage receives incoming packets and generates, in response, first and second processed data streams using a first set of rules. The first processing stage optionally detects whether the received packets are suspected of attacking the network and places the received data packets in the first processed data stream. The second processing stage receives the first processed data stream and generates, in response, a third processed data stream using a second set of rules. The second processing stage optionally classifies the first processed data stream, that is suspected of launching a network attack, as either attacks or benign network traffic. A third processing stage receives and processes the second and third processed data streams.