Patents by Inventor Anthony Popowicz

Anthony Popowicz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of diagnosing and treating hyperproliferative disorders
    Publication number: 20180237517
    Abstract: The invention relates to compositions and methods for diagnosing and treating hyperproliferative disorders using ligands which specifically recognize the hypusine and/or folate binding region of mature eukaryotic translation initiation factor 5A (hypusine-containing eIF-5A). The invention further relates to methods of identifying molecules which displace immunoreagents binding to mature eIF-5A. Such agents are useful for treating hyperproliferative disorders.
    Type: Application
    Filed: January 2, 2014
    Publication date: August 23, 2018
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Hartmut M. Hanauske-Abel, Myung-Hee Park, Edith C. Wolff, Debra Sheldon-Heller, Bernadette M. Cracchiolo, Anthony Popowicz, Paul M. Clement
  • Methods of diagnosing and treating hyperproliferative disorders
    Publication number: 20170226201
    Abstract: The invention relates to compositions and methods for diagnosing and treating hyperproliferative disorders using ligands which specifically recognize the hypusine and/or folate binding region of mature eukaryotic translation initiation factor 5A (hypusine-containing eIF-5A). The invention further relates to methods of identifying molecules which displace immunoreagents binding to mature eIF-5A. Such agents are useful for treating hyperproliferative disorders.
    Type: Application
    Filed: January 2, 2014
    Publication date: August 10, 2017
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Hartmut M. Hanauske-Abel, Myung-Hee Park, Edith C. Wolff, Debra Sheldon-Heller, Bernadette M. Cracchiolo, Anthony Popowicz, Paul M. Clement
  • Methods of diagnosing and treating hyperproliferative disorders
    Publication number: 20090253777
    Abstract: The invention relates to compositions and methods for diagnosing and treating hyperproliferative disorders using ligands which specifically recognize the hypusine and/or folate binding region of mature eukaryotic translation initiation factor 5A (hypusine-containing eIF-5A). The invention further relates to methods of identifying molecules which displace immunoreagents binding to mature eIF-5A. Such agents are useful for treating hyperproliferative disorders.
    Type: Application
    Filed: September 13, 2003
    Publication date: October 8, 2009
    Inventors: Hartmut M. Hanauske-Abel, Myung-Hee Park, Edith C. Wolff, Debra Sheldon-Heller, Bernadette M. Cracciolo, Anthony Popowicz, Paul M.J. Clement
  • Inhibitor development for 4-hydroxyphenylpyruvate dioxygenase, employing tyrosinemia 1 as a model for human diseases mediated by 2-oxoacid utilizing dioxygenases
    Publication number: 20050288187
    Abstract: The present invention is directed to a method of inhibiting 4-hydroxyphenylpyruvate dioxygenase in a living system by administering to the living system an effective amount of a compound of formulas I or II or III or derivatives thereof as follows: R1, R2, R3, and R4 each individually represent a hydrogen, an alkyl, alkenyl, or alkoxy group containing 1 to about 8 carbon atoms, an aryl, aralkyl, or cycloalkyl group containing about 5 to 12 carbon atoms, or a carboalkoxy or carbamyl group containing up to 8 carbon atoms, or a peptide or peptidomimetic moiety containing 10 to about 30 carbon atoms under conditions effective to inhibit 4-hydroxyphenylpyruvate dioxygenase in the living system. These compounds are also useful in carrying out a method of treating a patient and a method of regulating plant growth.
    Type: Application
    Filed: July 2, 2003
    Publication date: December 29, 2005
    Inventors: Hartmut Hanauske-Abel, Anthony Popowicz