Patents by Inventor Anthony Pusateri

Anthony Pusateri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of anticoagulants in the production of recombinant proteins in the milk of transgenic animals
    Patent number: 9546381
    Abstract: The invention relates to the production of recombinant human fibrinogen (rhFib) in the milk of transgenic mammalian animals. This production and subsequent purification process is generally hampered by the occurrence of so-called ‘clots’ and ‘flakes’ in the milk which, in severe cases, may prevent the cow from being milked at all, resulting in a halt of lactation. These clots and flakes occur because of the expression of the fibrinogen protein, which is a factor that is normally involved in blood clotting. The invention relates to solving this milk clotting problem by treating the (lactating) animals with anticoagulants such as coumarins. A preferred anticoagulant that is used in the methods of the present invention is warfarin.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: January 17, 2017
    Assignee: PHARMING INTELLECTUAL PROPERTY BV
    Inventors: Kathryn Margaret Nelson, Michael William Mosesson, Anthony Pusateri, Erik Jordahl Forsberg
  • Targeted Delivery of Factor VIII Proteins to Platelets
    Publication number: 20160251409
    Abstract: The invention described herein relates to novel molecules and polypeptides comprising at least one amino acid sequence having significant identity with (homology to) human Factor VIII or biologically active portion(s) thereof, related molecules (such as nucleic acids encoding such polypeptides), compositions (such as pharmaceutical formulations) comprising such polypeptides, and methods of making and using such polypeptides.
    Type: Application
    Filed: May 19, 2016
    Publication date: September 1, 2016
    Inventors: Henrik Oestergaard, Anthony Pusateri, Thomas R. Barnett, Jens Buchardt, Bernd Peschke, Mikael Kofod-Hansen, Magali A. Zundel, Carsten Behrens, Eva H. Norling Olsen, Henning Stennicke
  • Use of Anticoagulants in the Production of Recombinant Proteins in the Milk of Transgenic Animals
    Publication number: 20130053546
    Abstract: The invention relates to the production of recombinant human fibrinogen (rhFib) in the milk of transgenic mammalian animals. This production and subsequent purification process is generally hampered by the occurrence of so-called ‘clots’ and ‘flakes’ in the milk which, in severe cases, may prevent the cow from being milked at all, resulting in a halt of lactation. These clots and flakes occur because of the expression of the fibrinogen protein, which is a factor that is normally involved in blood clotting. The invention relates to solving this milk clotting problem by treating the (lactating) animals with anticoagulants such as coumarins. A preferred anticoagulant that is used in the methods of the present invention is warfarin.
    Type: Application
    Filed: March 11, 2011
    Publication date: February 28, 2013
    Applicant: PHARMING INTELLECTUAL PROPERTY BV
    Inventors: Kathryn Margaret Nelson, Michael William Mosesson, Anthony Pusateri, Erik Jordahl Forsberg
  • TARGETED DELIVERY OF FACTOR VIII PROTEINS TO PLATELETS
    Publication number: 20120093840
    Abstract: The invention described herein relates to novel molecules and polypeptides comprising at least one amino acid sequence having significant identity with (homology to) human Factor VIII or biologically active portion(s) thereof, related molecules (such as nucleic acids encoding such polypeptides), compositions (such as pharmaceutical formulations) comprising such polypeptides, and methods of making and using such polypeptides.
    Type: Application
    Filed: April 6, 2010
    Publication date: April 19, 2012
    Applicant: Novo Nordisk A/S
    Inventors: Henrik Østergaard, Anthony Pusateri, Thomas R. Barnett, Jens Buchardt, Bernd Peschke, Mikael Kofod-Hansen, Magali A. Zundel, Carsten Behrens, Eva H. Norling Olsen, Henning Stennicke