Abstract: A gateway device is disclosed for use in an internet-of-things environment. The gateway device comprises a sensor interface for interfacing with a plurality of sensors. A first memory unit is provided for storing sensed data received from the sensors. A second memory unit is provided for storing template data associated with the sensors which is generated by the sensor interface. A processing module is configured for generating encoded messages associated with the respective sensors containing the sensed data and the template data. A communication module is operable for communicating the encoded messages to a central server for decoding.

Abstract: Recombinant human lysosomal acid lipase (rhLAL) containing an N-terminal truncation, a composition of truncated recombinant human LAL (TLAL), an isolated mixture comprising TLAL and at least one other form of rhLAL are disclosed. A method of purifying TLAL from a mixture of LAL proteins, pharmaceutical compositions comprising TLAL and methods of producing TLAL are further disclosed.

Abstract: The present invention provides compositions of recombinant human lysosomal acid lipase having particular glycosylation patterns for internalization into target cells, a vector containing the nucleic acid encoding human lysosomal acid lipase, a host cell transformed with the vector, pharmaceutical compositions comprising the recombinant human lysosomal acid lipase and method of treating conditions associated with lysosomal acid lipase deficiency.

Abstract: The present invention provides a novel fusion polypeptide containing a catalytic domain of NPP1 fused to a targeting moiety, nucleic acids encoding the fusion polypeptide, a vector containing the nucleic acid integrated thereinto, a host cell transformed with the vector and pharmaceutical compositions comprising the fusion polypeptide.

Abstract: The present invention provides a novel fusion polypeptide containing a catalytic portion of NPP1 fused to a targeting moiety, nucleic acids encoding the fusion polypeptide, a vector containing the nucleic acid integrated thereinto, a host cell transformed with the vector and pharmaceutical compositions comprising the fusion polypeptide.

Abstract: The present invention provides methods of treating LAL deficiency comprising administering to a mammal a therapeutically effective amount of lysosomal acid lipase with an effective dosage frequency. Methods of improving growth and liver function, increasing LAL tissue concentration, and increasing LAL activity in a human patient suffering from LAL deficiency are also provided.

Abstract: The present invention provides a novel fusion polypeptide containing a catalytic portion of NPP1 fused to a targeting moiety, nucleic acids encoding the fusion polypeptide, a vector containing the nucleic acid integrated thereinto, a host cell transformed with the vector and pharmaceutical compositions comprising the fusion polypeptide.

Abstract: The present invention provides compositions comprising an isolated mixture of recombinant human NaGlu proteins in which a substantial amount of the NaGlu proteins in the mixture has increased levels of phosphorylated mannose that confer the proteins to be efficiently internalized into human cells. The present invention also provides methods of producing such mixture of NaGlu proteins, vectors used in transgenesis and expression, host cells harboring such vectors, and methods of isolating and purifying the mixture of NaGlu proteins. The invention further provides methods of treating NaGlu associated diseases.

Abstract: The present invention provides a novel fusion polypeptide containing a catalytic domain of NPP1 fused to a targeting moiety, nucleic acids encoding the fusion polypeptide, a vector containing the nucleic acid integrated thereinto, a host cell transformed with the vector and pharmaceutical compositions comprising the fusion polypeptide.

Abstract: The present invention provides methods of treating LAL deficiency comprising administering to a mammal a therapeutically effective amount of lysosomal acid lipase with an effective dosage frequency. Methods of improving growth and liver function, increasing LAL tissue concentration, and increasing LAL activity in a human patient suffering from LAL deficiency are also provided.

Abstract: The present invention provides a novel fusion polypeptide containing a catalytic portion of NPP1 fused to a targeting moiety, nucleic acids encoding the fusion polypeptide, a vector containing the nucleic acid integrated thereinto, a host cell transformed with the vector and pharmaceutical compositions comprising the fusion polypeptide.

Abstract: The present invention provides compositions of recombinant human lysosomal acid lipase having particular glycosylation patterns for internalization into target cells, a vector containing the nucleic acid encoding human lysosomal acid lipase, a host cell transformed with the vector, pharmaceutical compositions comprising the recombinant human lysosomal acid lipase and method of treating conditions associated with lysosomal acid lipase deficiency.

Abstract: The present invention provides methods of treating LAL deficiency comprising administering to a mammal a therapeutically effective amount of lysosomal acid lipase with an effective dosage frequency. Methods of improving growth and liver function, increasing LAL tissue concentration, and increasing LAL activity in a human patient suffering from LAL deficiency are also provided.

Abstract: Modified GAD65 compositions antagonize the activities of islet-specific T cells that contribute to the progression of one or more autoimmune disorders. The compositions are also antagonistic in humanized mice that express human HLA alleles associated with increased-risk of Type 1 diabetes.

Abstract: An exercise apparatus for exercising multiple body parts includes a frame and a front user bearer assembly which is angularly and height adjustable relative to the frame. The front bearer assembly is mounted to a guide for guiding upward and downward movement of the front bearer assembly. A compensator to ensure that the front assembly travels in a substantially vertical plane during exercise includes a number of support elements, which are pivotally mounted.

Abstract: Apparatus for exercising muscles of the chest and back includes a frame, parallel bars and overhead bars attached to the frame. A seat supports a user during exercise and a weight stack can be adjusted to suit the user. The seat is vertically movable relative to the frame as exercises are being performed by the user.

Abstract: Modified GAD65 compositions antagonize the activities of islet-specific T cells that contribute to the progression of one or more autoimmune disorders. The compositions are also antagonistic in humanized mice that express human HLA alleles associated with increased-risk of Type 1 diabetes.

Abstract: Apparatus for exercising muscles of the chest and back comprises a frame (10), parallel bars (21) and overhead bars (30) attached to the frame (10). A seat (11) supports a user during exercise and a resistance means in the form of a weight stack (52) can be adjusted to suit the user. The seat (11) is vertically movable relative to the frame (10) as exercises are being performed by the user.

Abstract: An exercise apparatus for exercising multiple body parts comprises a frame 1 and a front user bearer assembly 2 which is angularly and height adjustable relative to the frame 1. The front bearer assembly 2 is mounted to a guide means for guiding upward and downward movement of the front bearer assembly 2. Compensating means to ensure that the front assembly travels in a substantially vertical plane during exercise comprises a number of support elements 50, 51 which are pivotally mounted.

Abstract: A method, computer readable medium, and system for managing windows within an Internet environment includes determining at a first system which of one or more of settings to use for one or more windows within an Internet browser window in a second system remote from the first system. At least one of one or more attributes in the one or more settings is adjustable. The one or more windows with the determined one of the settings are docked in the Internet browser window in the second system.