Abstract: The deflectable tip catheters can be used with a primary delivery system (e.g., a bronchoscope, endoscope, or other surgical access device) to access a certain target tissue, such as a tumor (e.g., a lung tumor). The primary access device provides initial access and the deflectable tip catheter can be passed through the primary access device to reach the target tissue which is not otherwise accessible by the primary access device. The deflectable tip catheters have an internal bore free of obstructions such that a drug delivery device (e.g., a needle) or a diagnostic tool can be passed therethrough to directly access the target tissue.

Abstract: Various exemplary methods and devices (10, 110, 210) for delivering liquid therapeutic agents in solid tumors are provided. In general, a delivery device configured to deliver a liquid therapeutic agent into a solid tumor or other soft tissue can be configured to compress tissue and seal any fluid gaps around the delivery device during the delivery of the liquid therapeutic agent. In an exemplary embodiment the delivery device includes three elongate tubular shafts (12, 14, 16, 112, 114, 116, 212, 214, 216) configured to move longitudinally relative to one another. The elongate tubular shafts are configured to cooperate with one another to deliver the liquid therapeutic agent through a passageway of the delivery device to the solid tumor or other soft tissue and seal any fluid gaps around the delivery device while the liquid therapeutic agent is delivered into the solid tumor or other soft tissue.

Abstract: Smart pill bottle caps are provided. In general, a smart pill bottle cap can include a housing. The housing can include a sensor that is configured to monitor one or more characteristics of a pill bottle to which the housing is attached and can include a communication mechanism configured to communicate the one or more characteristics of the pill bottle to an external device. The communicated characteristic(s) of the pill bottle can be used to track usage of pills in the pill bottle, such as a date and time of when a pill was taken and/or a number of pills remaining in the pill bottle. A smart pill bottle cap can also be configured to engage a secondary, standard pill bottle cap that is used with a standard pill bottle.

Abstract: Various exemplary drug delivery device sensing modules and methods of using drug delivery device sensing modules are provided. In general, a sensing module can be configured to be attached to a drug delivery device configured to deliver a drug. The drug delivery device can be any of a variety of types of drug delivery devices, such as a syringe, an injection device (e.g., an autoinjector, a jet injector, and an infusion pump), a nasal delivery device, and an inhaler. The sensing module can be configured to gather data for one or more parameters related to drug delivery and to transmit data indicative of the gathered data to an external source configured to analyze the data received from the sensing module.

Abstract: Various exemplary steerable needles, methods of using steerable needles, and methods of manufacturing steerable needles are provided. In general, a needle configured to be advanced through soft tissue can be configured to be passively steered in a desired direction through the soft tissue. The needle can include a distal tip configured to facilitate the steering. The needle's distal tip can include a beveled or chamfered edge on one side thereof. The distal tip of the needle can be configured to bend relative to a remainder of the needle in a direction opposite to the side of the distal tip that includes the chamfered edge. The soft tissue can provide resistance to the distal tip being advanced therein such that the distal tip automatically bends in a direction away from the chamfered edge. The needle can also include a bendable portion that is proximal to the distal tip.

Abstract: In general, systems for administering a dmg are provided. In an exemplary embodiment, a dmg administration system includes a dmg administration device configured to communicate with a computer system and at least one sensor configured to obtain sensor data and communicate the sensor data to the drug administration device. The dmg administration device is configured to utilize a first drug dosing scheme when a drug is delivered to a patient, determine a second drug dosing scheme for delivering a drug to the patient dependent on dosing data from the computer system and sensor data collected by the sensor during and/or after the delivery of the first drug according to the first drug dosing scheme, and utilize the second drug dosing scheme when the drug is delivered to the patient.

Abstract: In general, drug administration devices configured to communicate with networks and external devices are provided. In an exemplary embodiment, a drug administration device is configured to adjust an operational parameter of the drug administration device based on a data packet formed from drug administration data ancillary data received from networks and/or external devices. In another example embodiment, a drug administration device is configured to scan for and establish communications with at least one external device. In another example embodiment, a method includes assessing whether to update a control program on a drug administration device from a network or external device. In another example embodiment, a system includes a first drug administration device configured to communicate with a second drug administration device to optimize a drug treatment.

Abstract: The present disclosure relates to drug administration. In an exemplary embodiment, a system can include a drug administration device configured to dispense a drug to a patient, a monitoring device configured to log a delivery event of drug delivery from the drug administration device into the patient, and a sensor configured to sense a patient parameter following delivery of the drug into the patient. In another exemplary embodiment, a drug administration device can include a drug holder configured to hold a drug, a dispensing mechanism configured to dispense the drug, and a sensor configured to sense a patient parameter, and the drug administration device can be configured to locally activate the drug at a target location in the patient. In another exemplary embodiment, methods, devices, and systems are provided to assess when operation of a drug dispensing mechanism is complete and to confirm whether drug administration was successful.

Abstract: Drug delivery systems and methods are provided for monitoring and/or tracking exposure of a drug to one or more conditions that can affect performance of the drug.

Abstract: A medical patch having a multi-piece bottom liner including a central liner sequentially removable independently of two outer perimeter liners. The multi-piece liner covering two adhesives of different peel force. Removal of the central liner exposes a first temporary/repositionable adhesive. Once properly positioned, the outer perimeter liners are removed to expose a second stronger adhesive. A foam cushioning layer is disposed beneath and extends beyond a footprint of every printed circuit board to prevent skin irritation. The medical patch may be designed specifically for stimulation of the sacral (S3 foramen) spinal nerve without the use of a separate mechanical placement tool or assistance by another.

Abstract: A device for providing transdermal electrical stimulation at an adjustable position on a head. The device including a supporting member economically shaped and configured to be fixedly supported about an anatomical body part; the supporting member being adjustably positionable in only two directions substantially perpendicular to one another. No electrical stimulation is provided by the supporting member. Alternatively, the device includes at least one pair of electrodes for producing the transdermal electrical stimulation to the head. The electrodes are mounted to a securing member shaped and configured to be releasably securable only about a plurality of strands of hair at a predetermined fixed orientation without being secured about any anatomical body part.

Abstract: A device for providing transdermal electrical stimulation at an adjustable position on a head. The device including a supporting member ergonomically shaped and configured to be fixedly supported about an anatomical body part; the supporting member being adjustably positionable in only two directions substantially perpendicular to one another. No electrical stimulation is provided by the supporting member. Alternatively, the device includes at least one pair of electrodes for producing the transdermal electrical stimulation to the head. The electrodes are mounted to a securing member shaped and configured to be releasably securable only about a plurality of strands of hair at a predetermined fixed orientation without being secured about any anatomical body part.

Abstract: A system and method for stimulating a target such as a nerve, wherein the system includes a first waveform generator adapted to generate a first waveform having a frequency capable of stimulating a predetermined target of the mammal, a second waveform generator adapted to generate a carrier waveform having a frequency capable of passing through tissue of the mammal, a modulation device electrically coupled to the first and second waveform generators and adapted to modulate the first and carrier waveforms to create a modulated waveform, and an electrode electrically coupled to the modulation device and positioned substantially adjacent to skin of the mammal, and adapted to apply the modulated waveform thereto.

Abstract: Self-positioning of at least a portion of a transdermal electrical stimulation patch within a target area (e.g., supraclavicular fossa region) of a human body to activate a depot of brown adipose tissue therein. An electric field is generated using the electrical stimulation patch to activate the brown adipose tissue within the supraclavicular fossa region of the body. The patch is self-positioned using one or more anatomical points (e.g., anatomical landmarks and/or anatomical features) or markings on the body. Brown adipose tissue may also be activated by applying an electrical signal to a body piercing partially implanted proximate a target area in which the tissue is disposed.

Abstract: Self-positioning of at least a portion of a transdermal electrical stimulation patch within a target area (e.g., supraclavicular fossa region) of a human body to activate a depot of brown adipose tissue therein. An electric field is generated using the electrical stimulation patch to activate the brown adipose tissue within the supraclavicular fossa region of the body. The patch is self-positioned using one or more anatomical points (e.g., anatomical landmarks and/or anatomical features) or markings on the body. Brown adipose tissue may also be activated by applying an electrical signal to a body piercing partially implanted proximate a target area in which the tissue is disposed.

Abstract: A medical patch having a multi-piece bottom liner including a central liner sequentially removable independently of two outer perimeter liners. The multi-piece liner covering two adhesives of different peel force. Removal of the central liner exposes a first temporary/repositionable adhesive. Once properly positioned, the outer perimeter liners are removed to expose a second stronger adhesive. A foam cushioning layer is disposed beneath and extends beyond a footprint of every printed circuit board to prevent skin irritation. The medical patch may be designed specifically for stimulation of the sacral (S3 foramen) spinal nerve without the use of a separate mechanical placement tool or assistance by another.