Patents by Inventor Anthony R. Gangloff

Anthony R. Gangloff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heteroarylamide inhibitors of TBK1
    Patent number: 9994547
    Abstract: Disclosed are compounds of formula 1: which are useful as inhibitors of TBK1. Also disclosed are pharmaceutical compositions which contain the compounds, methods for treatment of conditions associated with TBK1, and processes for making the compounds and intermediates thereof.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: June 12, 2018
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Simone Bigi, Walter Keung, Steve Swann, Phong H. Vu, Steven John Woodhead, Anthony R. Gangloff
  • HETEROARYLAMIDE INHIBITORS OF TBK1
    Publication number: 20170313675
    Abstract: Disclosed are compounds of formula 1: which are useful as inhibitors of TBK1. Also disclosed are pharmaceutical compositions which contain the compounds, methods for treatment of conditions associated with TBK1, and processes for making the compounds and intermediates thereof.
    Type: Application
    Filed: October 2, 2015
    Publication date: November 2, 2017
    Inventors: Simone Bigi, Walter Keung, Steve Swann, Phong H. Vu, Steven John Woodhead, Anthony R. Gangloff
  • Heteroarylamide inhibitors of TBK1
    Patent number: 9598424
    Abstract: The present invention provides compounds of formula 1: which are useful as inhibitors of TBK-1, pharmaceutical compositionst thereof, methods for treatment of conditions associated with TBK1, processes for making the compounds and intermediates thereof.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: March 21, 2017
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Walter Keung, Lily Kwok, Mark Sabat, Nicholas Scorah, Haixia Wang, Steven John Woodhead, Anthony R Gangloff
  • HETEROARYLAMIDE INHIBITORS OF TBK1
    Publication number: 20170015669
    Abstract: The present invention provides compounds of formula 1: which are useful as inhibitors of TBK-1, pharmaceutical compositions thereof, methods for treatment of conditions associated with TBK1, processes for making the compounds and intermediates thereof.
    Type: Application
    Filed: February 12, 2015
    Publication date: January 19, 2017
    Inventors: Walter Keung, Lily Kwok, Mark Sabat, Nicholas Scorah, Haixia Wang, Steven John Woodhead, Anthony R Gangloff
  • Substituted pyrido[3,2-e]pyrrolo[1,2-a]pyrazines as inhibitors of poly(ADP-ribose)polymerase (PARP)
    Patent number: 9187497
    Abstract: Disclosed are compounds of the following formula: in which R1, R2, R5, R6, R7, R31, u, and X are defined in the specification. Also disclosed are pharmaceutical compositions, kits, and articles of manufacture, which contain the compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions related to PARP activity.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: November 17, 2015
    Assignee: Takeda Phamaceutical Company Limited
    Inventors: Anthony R. Gangloff, Andrew John Jennings, Benjamin Jones, Andre A. Kiryanov
  • Poly (ADP-ribose) polymerase (PARP) inhibitors
    Patent number: 8980902
    Abstract: Compounds of the following formula are provided for use with PARP: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits, and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds.
    Type: Grant
    Filed: September 18, 2013
    Date of Patent: March 17, 2015
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jason W. Brown, Anthony R. Gangloff, Andre K. Kiryanov
  • POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS
    Publication number: 20150031652
    Abstract: Disclosed are compounds of the following formula: in which R1, R2, R3, R4, R5, R6, R7, X, and t are defined in the specification. Also disclosed are pharmaceutical compositions, kits, and articles of manufacture, which contain the compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions related to PARP activity.
    Type: Application
    Filed: August 1, 2014
    Publication date: January 29, 2015
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Anthony R. Gangloff, Andrew John Jennings, Benjamin Jones, Andre A. Kiryanov
  • Substituted pyrido[2,3-b]pyrazines
    Patent number: 8822470
    Abstract: Disclosed are compounds of the following formula: in which R1, R2, R3, R4, R5, R6, R7, and X, are defined in the specification. Also disclosed are pharmaceutical compositions, kits, and articles of manufacture, which contain the compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions related to PARP activity.
    Type: Grant
    Filed: May 8, 2013
    Date of Patent: September 2, 2014
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Anthony R. Gangloff, Andrew John Jennings, Benjamin Jones, Andre A. Kiryanov
  • Poly (ADP-ribose) polymerase (PARP) inhibitors
    Patent number: 8669249
    Abstract: Compounds of the following formula are provided for use in inhibiting Poly (ADP-ribose) Polymerase (PARP): wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: March 11, 2014
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jason W. Brown, Anthony R. Gangloff, Andrew John Jennings, Phong H. Vu
  • POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS
    Publication number: 20140024654
    Abstract: Compounds of the following formula are provided for use with PARP: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits, and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds.
    Type: Application
    Filed: September 18, 2013
    Publication date: January 23, 2014
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Jason W. Brown, Anthony R. Gangloff, Andre K. Kiryanov
  • POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS
    Publication number: 20130274239
    Abstract: Disclosed are compounds of the following formula: in which R1, R2, R3, R4, R5, R6, R7, X, and t are defined in the specification. Also disclosed are pharmaceutical compositions, kits, and articles of manufacture, which contain the compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions related to PARP activity.
    Type: Application
    Filed: May 8, 2013
    Publication date: October 17, 2013
    Inventors: Anthony R. Gangloff, Andrew John Jennings, Benjamin Jones, Andre A. A. Kiryanov
  • Poly (ADP-ribose) polymerase (PARP) inhibitors
    Patent number: 8541417
    Abstract: Compounds of the following formula are provided for use with PARP: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits, and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds.
    Type: Grant
    Filed: July 29, 2010
    Date of Patent: September 24, 2013
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jason W. Brown, Anthony R. Gangloff, Andre A. Kiryanov
  • Substituted derivatives of pyrido[3,2-e][1,4]thiazino[4,3-a]pyrazine and pyrido[3,2-e][1,4]oxazino[4,3-a]pyrazine
    Patent number: 8450323
    Abstract: Disclosed are compounds of the following formula: in which R1, R2, R6, R7, R12, X, and q are defined in the specification. Also disclosed are pharmaceutical compositions, kits, and articles of manufacture, which contain the compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions related to PARP activity.
    Type: Grant
    Filed: January 18, 2012
    Date of Patent: May 28, 2013
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Anthony R. Gangloff, Andrew John Jennings, Benjamin Jones, Andre A. Kiryanov
  • POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS
    Publication number: 20120129868
    Abstract: Compounds of the following formula are provided for use with PARP: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits, and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds.
    Type: Application
    Filed: July 29, 2010
    Publication date: May 24, 2012
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Jason W. Brown, Anthony R. Gangloff, Andre A. Kiryanov
  • Poly (ADP-Ribose) Polymerase (PARP) Inhibitors
    Publication number: 20120122835
    Abstract: Disclosed are compounds of the following formula: in which R1, R2, R3, R4, R5, R6, R7, X, and t are defined in the specification. Also disclosed are pharmaceutical compositions, kits, and articles of manufacture, which contain the compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions related to PARP activity.
    Type: Application
    Filed: January 18, 2012
    Publication date: May 17, 2012
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Anthony R. Gangloff, Andrew John Jennings, Benjamin Jones, Andre A. Kiryanov
  • POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS
    Publication number: 20120094992
    Abstract: Compounds of the following formula are provided for use in inhibiting Poly (ADP-ribose) Polymerase (PARP): wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds.
    Type: Application
    Filed: March 26, 2010
    Publication date: April 19, 2012
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Jason W. Brown, Anthony R. Gangloff, Andrew John Jennings, Phong H. Vu
  • Substituted 7,8,9,10-tetrahydro-5H-dipyrido[1,2-a:3?,2?-e]pyrazin-6(6aH)-ones
    Patent number: 8124606
    Abstract: Disclosed are compounds of the following formula: in which R1, R2, R5, R6, R7, R11, X, and m are defined in the specification. Also disclosed are pharmaceutical compositions, kits, and articles of manufacture, which contain the compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions related to PARP activity.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: February 28, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Anthony R. Gangloff, Andrew John Jennings, Benjamin Jones, Andre A. Kiryanov
  • Poly (ADP-Ribose) Polymerase (PARP) INHIBITORS
    Publication number: 20110158989
    Abstract: Disclosed are compounds of the following formula: in which R1, R2, R3, R4, R5, R6, R7, X, and t are defined in the specification. Also disclosed are pharmaceutical compositions, kits, and articles of manufacture, which contain the compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions related to PARP activity.
    Type: Application
    Filed: March 4, 2011
    Publication date: June 30, 2011
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Anthony R. Gangloff, Andrew John Jennings, Benjamin Jones, Andre A. Kiryanov
  • Substituted 6a,7,8,9-tetrahydropyrido[3,2-e]pyrrolo[1,2-a]pyrazin-6(5H)-ones
    Patent number: 7928105
    Abstract: Disclosed are compounds of the following formula: in which R1, R2, R5, R6, R7, R31, u, and X are defined in the specification. Also disclosed are pharmaceutical compositions, kits, and articles of manufacture, which contain the compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions related to PARP activity.
    Type: Grant
    Filed: January 21, 2010
    Date of Patent: April 19, 2011
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Anthony R. Gangloff, Andrew John Jennings, Benjamin Jones, Andre A. Kiryanov
  • Poly (ADP-Ribose) Polymerase (PARP) Inhibitors
    Publication number: 20100190763
    Abstract: Disclosed are compounds of the following formula: in which R1, R2, R3, R4, R5, R6, R7, X, and t are defined in the specification. Also disclosed are pharmaceutical compositions, kits, and articles of manufacture, which contain the compounds, methods and intermediates useful for making the compounds, and methods of using the compounds to treat diseases, disorders, and conditions related to PARP activity.
    Type: Application
    Filed: January 21, 2010
    Publication date: July 29, 2010
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Anthony R. Gangloff, Andrew John Jennings, Benjamin Jones, Andre A. Kiryanov