Abstract: Methods are disclosed for analyzing sequence data to identify putative structural variants (SVs), filter out germline SVs and artifacts from sample handling and sequencing to leave only somatic SVs. Recognizing that those somatic SVs, especially where sequenced from a tumor or other sample of diseased tissue, may be indicative of the presence of disease, methods may include designing primers to selectively amplify those somatic SVs for monitoring disease progression or recurrence in patient samples including blood. In various embodiments, the original sequence data may be obtained from FFPE-extracted or fresh frozen-extracted DNA and somatic SVs may be identified without the benefit of a matched normal sequence. In some embodiments, machine learning analysis may be used in the identification of SVs, the filtering of artifacts and germline SVs, and/or primer and probe design for disease monitoring.

Abstract: A method of securely reporting events on a computing device comprising a web browser, the method comprising providing a loader to the computing device and the loader providing a wrapper to the web browser for execution by the web browser, wherein the wrapper is a closure. The loader establishing a secure communication path from the loader to the wrapper, and a secure communication path from the wrapper to the loader. The wrapper establishing an inline frame “IFrame” within the web browser, wherein the IFrame comprises a universal resource locator which points to a kernel. Establishing a firewall around the IFrame. Establishing a secure communication path from the wrapper to the kernel. Establishing a secure communication path from the kernel to the wrapper. Providing an event reporter to the IFrame through the loader, wrapper and kernel using the established secure communication paths from the loader to the wrapper and from the wrapper to the kernel, and running the event reporter in the IFrame.

Abstract: According to aspects of the technology there are provided a computer-implemented method for distributing content from one or more content sources over a communications network to a plurality of users by a master node of a content distribution system, the content distribution system further comprising a plurality of local nodes in communication with the master node, each local node serving a group of users from the plurality of users, the method comprising: maintaining a content directory associated with a plurality of content items of the one or more content sources, the content directory comprising content location data for the plurality of content items and information associated with each of the content item; transmitting the content directory to one or more of the local nodes; maintaining a user profile bank comprising one or more user profiles for each of the plurality of users; and transmitting the user profile bank to one or more of the local nodes for use in generating, at each local node, user conten

Abstract: According to aspects of the technology there are provided a method for generating a content stream for playback on one or more content players from one or more content sources, the method comprising: receiving a content directory associated with a plurality of content items of the one or more content sources, the content directory comprising content location data for the plurality of content items and information associated with each content item; generating a playlist of content items based on content items in the content directory for user playback; receiving user feedback data from the content player for the user during playback, wherein the user feedback comprises data indicating a user has rejected playback of the one or more content items; and constructing a user profile of the user based on the user feedback data.

Abstract: According to aspects of the technology there are provided a method for distributing content from one or more content sources over a communications network to a plurality of users by a content distribution system, the content distribution system comprising a master node and a plurality of local nodes in communication with the master node, each local node serving a group of users from the plurality of users, the method comprising: maintaining, at the master node, a content directory associated with a plurality of content items from the one or more content sources, the content directory comprising content location data for the plurality of content items and information associated with each of the content items; generating, at each local node, user content location data for each user in the group of users based on selecting a plurality of content items from the content directory according to a user profile of each user, the user content location data for each user including locations of the selected content items

Abstract: According to aspects of the technology there are provided a computer-implemented method for distributing content from one or more content sources over a communications network to a plurality of content players each associated with a user of a content distribution system, the method comprising: receiving a content directory associated with a plurality of content items of the one or more content sources, the content directory comprising content location data for the plurality of content items and information associated with each content item; retrieving the content items using the received user content location data from the one or more content sources for seamless playback of the selected content items; associating the content items with one or more related content items; and distributing the one or more related content items to each of the plurality of content players when the content item is being played back.

Abstract: According to aspects of the invention there are provided a method for modifying a content stream distributed to one or more users, the method comprising: generating a content stream comprising a plurality of content items from one or more content providers; constructing one or more filters for modifying the content steam, wherein the one or more filters is constructed by defining one or more parameters relating the content items; applying the one or more filters to the content stream; selecting one or more content items from the content stream based on defined parameters; and modifying the content stream by applying the constructed filter to the plurality of content items in the content stream.

Abstract: According to aspects of the technology there are provided a computer-implemented method for generating a content stream comprising a plurality of content items from one or more content sources, the method comprising: defining one or more instances in each content item of the plurality of content items based on one or more parameters; defining one or more of the instances in each content item as a start point from which to commence playback of the content item; and playing back the content item from the defined start point.

Abstract: A metrics data management apparatus and method is disclosed comprising receiving event data of a series of events from a source, processing the event data into a format identifying the source and a session of each event; populating the event data relevant to a series of connected events of a single session into an event repository, and a session build module to determining a complete session from event data relevant to a series of connected events of a single session by a predetermined event.

Abstract: A method of determining the audio level of a network partner media player, wherein, when media playing on a terminal media player running on a terminal originates from an external media source, the method comprises obtaining activity information from the terminal, obtaining activity information from the terminal media player, obtaining activity information from an external source media player associated with the external media source, and analysing the activity information from the terminal, the activity information from the terminal media player, the activity information from the external media source media player, whereby the audio level of the network partner media player is determined.

Abstract: A metrics data management apparatus and method is disclosed comprising receiving event data of a series of events from a source, processing the event data into a format identifying the source and a session of each event; populating the event data relevant to a series of connected events of a single session into an event repository, and a session build module to determining a complete session from event data relevant to a series of connected events of a single session by a predetermined event.

Abstract: A method of determining whether media displayed on a web page in a web browser is visible comprising: determining whether the web page comprises at least one frame; and if the web page comprises at least one frame, using information relating to the activity of the media player to determine whether the media is visible.

Abstract: A method of determining whether media displayed on a web page in a web browser is visible comprising: determining whether the web page comprises at least one frame; and if the web page comprises at least one frame, using information relating to the activity of the media player to determine whether the media is visible.

Abstract: A method of determining whether media displayed on a web page in a web browser is visible comprising: determining whether the web page comprises at least one frame; and if the web page comprises at least one frame, using information relating to the activity of the media player to determine whether the media is visible.

Abstract: A method of quantifying the effectiveness of delivery of digital media content comprises identifying a group of instances of delivery of digital media content, calculating a plurality of metrics for the group, each metric indicative of a different aspect of effective delivery of the digital media content, and combining the calculated metrics into a single indicator of the effectiveness of the delivery of digital media content for the group. The group of instances can represent the delivery of digital media content by a particular supplier or a particular service of a particular supplier of digital media distribution services over a period of time. The metrics can be indicative of the proportion of the instances that were visible or audible to a viewer of the digital media content.