Abstract: Systems and methods for non-contact, non-invasive image construction of interior tissue are provided. Electromagnetic (EM) waves may be used to transmit through a high acoustic material or barrier, such as a bone, where the EM wave is then absorbed and converted to ultrasound (US) or audible band acoustic longitudinal waves or shear waves once past the high acoustic impedance barrier. The EM to acoustic converted waves are generated through thermoelastic mechanisms. This enables acoustic waves to propagate in the soft tissue on the opposing side of the barrier while minimizing reverberation and clutter. The US waves propagate within the tissue and may be measured using a detector, such as coherent lidar or optical band multipixel camera noninvasively outside the tissue. Furthermore, a phased array can be used to steer and shape the acoustic radiation pattern of the acoustic waves in the soft tissue beyond the bone or high acoustic impedance barrier.

Abstract: A system and method is provided for detecting an analyte within a sample. The method includes providing a first electromagnetic radiation to the sample in a manner that resonantly excites mechanical vibrations in the analyte. The method also includes providing a second electromagnetic radiation to the sample so as to interact with vibrating analyte, wherein a third electromagnetic radiation is produced based on the interaction. The method further includes receiving the a third electromagnetic radiation and determining the presence of the analyte based on the received a third electromagnetic radiation.

Abstract: An optical imaging method for analyzing an ex vivo tissue sample of a subject is provided. The method includes obtaining the ex vivo tissue sample, preparing the ex vivo tissue sample onto a sample receptacle of an optical imaging system, and emitting excitation light toward the ex vivo tissue sample. The method also includes acquiring imaging data of light emitted by the ex vivo tissue sample in response to the excitation light, analyzing the imaging data to determine whether the ex vivo tissue sample contains pathologic tissue, and generating an output indicating to an operator whether the ex vivo tissue sample contains pathologic tissue.

Abstract: Non-contact ultrasound imaging system. The system includes a pulsed near infrared scanning laser source for illuminating a surface of a structure to generate ultrasonic elastic waves that propagate into the structure. A laser Doppler vibrometer measures vibration of the surface caused by the propagating ultrasonic waves in the structure and a data acquisition module processes data from the vibrometer to construct an image of the structure.

Abstract: An optical imaging method for analyzing an ex vivo tissue sample of a subject is provided. The method includes obtaining the ex vivo tissue sample, preparing the ex vivo tissue sample onto a sample receptacle of an optical imaging system, and emitting excitation light toward the ex vivo tissue sample. The method also includes acquiring imaging data of light emitted by the ex vivo tissue sample in response to the excitation light, analyzing the imaging data to determine whether the ex vivo tissue sample contains pathologic tissue, and generating an output indicating to an operator whether the ex vivo tissue sample contains pathologic tissue.

Abstract: An interventional optical molecular imaging system and method are provided for use with a biopsy introducer needle. The system includes an imaging tool configured to slide coaxially through the biopsy introducer needle toward a tip of the biopsy introducer needle. The system also includes a laser illumination source coupled to the imaging tool, a camera configured to capture images from the imaging tool, and a computer coupled to the camera and the laser illumination source. The computer includes a processor configured to activate the laser illumination source to emit light through a tip of the imaging tool, collect imaging data from the camera after activating the laser illumination source, analyze the imaging data to determine a fluorescence measurement at the tip of the imaging tool, and display an indication of the fluorescence measurement.