Abstract: The invention relates to a tetanus neurotoxin (TeNT) conjugate comprising a TeNT conjugated to at least one masking moiety (i) through an acid labile linkage or (ii) comprising a masking polypeptide. The invention also relates to a composition comprising the TeNT conjugate and therapeutic use of the TeNT conjugate or composition for treating hypotonia in a subject or enhancing muscle power and/or muscle tone and/or muscle healing and/or sporting performance.

Abstract: The present invention is an adjustment means for a mandibular advancement device. The mandibular advancement device being of the type having both intraoral and extraoral portions, including a body portion that is at the interface between the intraoral and extraoral portions and thereby is part intraoral and part extraoral. The extraoral portion includes a lower arm that is substantially straight and extends directly outwardly from the extraoral part of the body portion, and a curved upper arm that curves upwardly from the lower arm and back towards the face of a person using the device. The posterior end of the upper arm includes a pad assembly that is adapted to make contact with, and apply pressure to, the subnasal maxillary bone of the wearer. A substantial portion of the lower arm is engageable with motorised means that are encapsulated within the body portion and are adapted to engage with the lower arm and cause it to slide further out of, or slidably retract further into, the body portion.

Abstract: The present invention provides adjustment means for a mandibular advancement device. The device includes both intraoral and extraoral portions. The intraoral portion includes a body portion. The body portion includes lower and upper plates. The lower plate is adapted to accommodate a pair of opposed arms that extend rearwardly and outwardly from the plate into the oral cavity when the device is worn. Each arm includes a posterior intraoral maxillary abutment surface. The lower plate includes a threaded hole on each side, adjacent a respective arm so that the threaded hole extends from the respective arm towards the edge of the plate.

Abstract: The invention relates to a composition comprising a first PEGylated tetanus neurotoxin (PEG-TeNT) comprising tetanus neurotoxin (TeNT) conjugated to polyethylene glycol (PEG) and a second TeNT. The invention also relates to various PEG-TeNTs. The invention also relates to a method of treating hypotonia using the composition or various PEG-TeNTs, and a kit comprising the composition or various PEG-TeNTs. In one embodiment, the hypotonia is obstructive sleep apnoea.

Abstract: A method of monitoring the status of a body of a person during sleep, said method comprising:—retaining in or adjacent the mouth or nose of said person an electronic detector which detects indications of the state of said body,—wirelessly transmitting a first data stream representing said indications to a data receiving means,—transmitting said first data stream from said data receiving means to a data processing means,—processing said first data stream within said data processing means to produce a second data stream representing said indications, or conclusion drawn from said indications, and—displaying a visual representation of said indications or conclusions.

Abstract: An electrical cable and a method for manufacturing the electrical cable are provided in which a plurality of insulated conductors have an inner protective layer extruded thereabout. A plurality of longitudinally extending ribs or fins or exterior ribbed or finned surfaces are formed outward of the inner protective layer between which exist a plurality of voids. An outer insulation layer can be formed in the same operation as the fins or ribbed surface and the inner layer or in a subsequent operation. A self-sealing elastomeric material is applied to the conductor surface or is present between the fins and between the inner protective layer and the outer insulation layer.

Abstract: An electrical cable and a method for manufacturing the electrical cable are provided in which a plurality of insulated conductors have an inner protective layer extruded thereabout. A plurality of longitudinally extending ribs or fins or exterior ribbed or finned surfaces are formed outward of the inner protective layer between which exist a plurality of voids. An outer insulation layer can be formed in the same operation as the fins or ribbed surface and the inner layer or in a subsequent operation. A self-sealing elastomeric material is applied to the conductor surface or is present between the fins and between the inner protective layer and the outer insulation layer.

Abstract: An electrical cable and a method for manufacturing the electrical cable are provided in which a plurality of insulated conductors have an inner protective layer extruded thereabout. A plurality of longitudinally extending ribs or fins or exterior ribbed or finned surfaces are formed outward of the inner protective layer between which exist a plurality of voids. An outer insulation layer can be formed in the same operation as the fins or ribbed surface and the inner layer or in a subsequent operation. A self-sealing elastomeric material is applied to the conductor surface or is present between the fins and between the inner protective layer and the outer insulation layer.

Abstract: An electrical cable and a method for manufacturing the electrical cable are provided in which a plurality of insulated conductors have an inner protective layer extruded thereabout. A plurality of longitudinally extending ribs or fins or exterior ribbed or finned surfaces are formed outward of the inner protective layer between which exist a plurality of voids. An outer insulation layer can be formed in the same operation as the fins or ribbed surface and the inner layer or in a subsequent operation. A self-sealing elastomeric material is applied to the conductor surface or is present between the fins and between the inner protective layer and the outer insulation layer.

Abstract: The present invention is directed to a matched permeability liner/absorbent structure system, suitable for use in absorbent articles, in which the permeability of the bodyside liner is correlated with the permeability of the subjacent layer of the absorbent structure, such as a surge layer. The inventors have observed that by appropriately matching the permeability of the liner material to the permeability of the subjacent layer, liquid intake performance of the liner and subjacent layer materials can exceed liquid intake performance of the subjacent layer material alone. Thus, in accordance with an embodiment of the present invention, the permeability of the bodyside liner is set within a specified range of that of the subjacent layer such that the liner/subjacent layer liquid intake performance is improved.

Abstract: Side-by-side conjugate filaments made from thermoplastic elastomers and spunbond-type polyolefins exhibit an extremely high propensity to self-crimp. At appropriate polymer ratios and processing conditions (with mechanical or aerodynamical drawing) the crimp develops spontaneously after relaxation of the attenuation force. The amount of crimp and the degree of elastic properties depend on the elastomer content and the processing conditions. The resulting crimp is typically in the range of 25-200 crimps per inch. This combination of exceptionally high crimp and an elastomer component imparts stretch and recovery properties. The filaments can be wrapped around a cylindrical supporting structure to create a continuous, seamless elastic band, useful for body-fit articles.

Abstract: The disclosed invention relates to split fibers and improved means and methods for obtaining them as well as their use in nonwovens and incorporation into personal care and other products. Multicomponent filaments are formed including at least two incompatible components. These filaments are drawn under hot aqueous, for example, steam, conditions causing them to split into fibers containing the incompatible components. These fibers are collected as a fine fiber nonwoven which finds utility as a component of sanitary napkins, diapers and other products.

Abstract: The present invention provides a splittable conjugate fiber containing at least two incompatible polymers that are arranged in distinct segments across the cross-section of the fiber, wherein the segments are continuous along the length of the fiber. The fiber can be characterized in that the segments of the fiber dissociate in less than about 30 seconds when contacted with a hot aqueous fibrillation-inducing medium. The invention also provides a fabric containing the split fibers produced from the precursor splittable conjugate fiber and laminates containing the split fiber fabric. Additionally provided is a process for producing the split fibers.

Abstract: There is provided a process which comprises the step of subjecting a just produced spunbond web to a high flow rate, heated stream of air across substantially the width of the web to very lightly bond the fibers of the web together. Such bonding should be the minimum necessary in order to satisfy the needs of further processing yet not detrimentally affect the web. The fibers of the web may be monocomponent or biconstituent and the web should be substantially free of adhesives and not subjected to compaction rolls.

Abstract: A shaped nonwoven fabric comprises continuous spunbond filaments made by directly forming the spunbond filaments into a web in a single process. The fabric has an array of discrete surface features such as apertures or projections, or both. The spunbond filaments are bonded together with an adhesive polymeric component so that the shape of the fabric is retained. The fabric can be engineered to have particular fluid handling properties, strength properties, abrasive properties and aesthetic properties. Articles such as personal care products, garments, medical products and cleaning products are also disclosed.