Abstract: The invention relates to a composition comprising a first PEGylated tetanus neurotoxin (PEG-TeNT) comprising tetanus neurotoxin (TeNT) conjugated to polyethylene glycol (PEG) and a second TeNT. The invention also relates to various PEG-TeNTs. The invention also relates to a method of treating hypotonia using the composition or various PEG-TeNTs, and a kit comprising the composition or various PEG-TeNTs. In one embodiment, the hypotonia is obstructive sleep apnoea.

Abstract: A method of monitoring the status of a body of a person during sleep, said method comprising: —retaining in or adjacent the mouth or nose of said person an electronic detector which detects indications of the state of said body, —wirelessly transmitting a first data stream representing said indications to a data receiving means, —transmitting said first data stream from said data receiving means to a data processing means, —processing said first data stream within said data processing means to produce a second data stream representing said indications, or conclusion drawn from said indications, and —displaying a visual representation of said indications or conclusions.

Abstract: The present invention is an adjustment means for a mandibular advancement device. The mandibular advancement device being of the type having both intraoral and extraoral portions, including a body portion that is at the interface between the intraoral and extraoral portions and thereby is part intraoral and part extraoral. The extraoral portion includes a lower arm that is substantially straight and extends directly outwardly from the extraoral part of the body portion, and a curved upper arm that curves upwardly from the lower arm and back towards the face of a person using the device. The posterior end of the upper arm includes a pad assembly that is adapted to make contact with, and apply pressure to, the subnasal maxillary bone of the wearer. A substantial portion of the lower arm is engageable with motorised means that are encapsulated within the body portion and are adapted to engage with the lower arm and cause it to slide further out of, or slidably retract further into, the body portion.

Abstract: The invention relates to a tetanus neurotoxin (TeNT) conjugate comprising a TeNT conjugated to at least one masking moiety (i) through an acid labile linkage or (ii) comprising a masking polypeptide. The invention also relates to a composition comprising the TeNT conjugate and therapeutic use of the TeNT conjugate or composition for treating hypotonia in a subject or enhancing muscle power and/or muscle tone and/or muscle healing and/or sporting performance.

Abstract: The present invention is an adjustment means for a mandibular advancement device. The mandibular advancement device being of the type having both intraoral and extraoral portions, including a body portion that is at the interface between the intraoral and extraoral portions and thereby is part intraoral and part extraoral. The extraoral portion includes a lower arm that is substantially straight and extends directly outwardly from the extraoral part of the body portion, and a curved upper arm that curves upwardly from the lower arm and back towards the face of a person using the device. The posterior end of the upper arm includes a pad assembly that is adapted to make contact with, and apply pressure to, the subnasal maxillary bone of the wearer. A substantial portion of the lower arm is engageable with motorised means that are encapsulated within the body portion and are adapted to engage with the lower arm and cause it to slide further out of, or slidably retract further into, the body portion.

Abstract: The present invention provides adjustment means for a mandibular advancement device. The device includes both intraoral and extraoral portions. The intraoral portion includes a body portion. The body portion includes lower and upper plates. The lower plate is adapted to accommodate a pair of opposed arms that extend rearwardly and outwardly from the plate into the oral cavity when the device is worn. Each arm includes a posterior intraoral maxillary abutment surface. The lower plate includes a threaded hole on each side, adjacent a respective arm so that the threaded hole extends from the respective arm towards the edge of the plate.

Abstract: The invention relates to a composition comprising a first PEGylated tetanus neurotoxin (PEG-TeNT) comprising tetanus neurotoxin (TeNT) conjugated to polyethylene glycol (PEG) and a second TeNT. The invention also relates to various PEG-TeNTs. The invention also relates to a method of treating hypotonia using the composition or various PEG-TeNTs, and a kit comprising the composition or various PEG-TeNTs. In one embodiment, the hypotonia is obstructive sleep apnoea.

Abstract: A method of monitoring the status of a body of a person during sleep, said method comprising:—retaining in or adjacent the mouth or nose of said person an electronic detector which detects indications of the state of said body,—wirelessly transmitting a first data stream representing said indications to a data receiving means,—transmitting said first data stream from said data receiving means to a data processing means,—processing said first data stream within said data processing means to produce a second data stream representing said indications, or conclusion drawn from said indications, and—displaying a visual representation of said indications or conclusions.