Patents by Inventor Anthony Sauve

Anthony Sauve has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives
    Patent number: 11926644
    Abstract: Disclosed is a compound of formula (I): wherein R1, R2, R3, and are as defined herein. Also disclosed are methods for increasing mammalian cell NAD+ production and improving mitochondrial cell densities comprising administering to a cell the compound or a salt thereof.
    Type: Grant
    Filed: July 27, 2021
    Date of Patent: March 12, 2024
    Assignee: Cornell University
    Inventors: Anthony Sauve, Farheen Sultana Mohammed, Yue Yang
  • Substituted alkylphenols as HCN1 antagonists
    Patent number: 11684590
    Abstract: Provided herein are compounds (e.g., compounds of Formula (I) and Formula (II), that modulate HCN channels, intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HCN-related disorders (e.g., pain) with the compounds in a subject, by administering the compounds and/or compositions described herein.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: June 27, 2023
    Assignee: Cornell University
    Inventors: Gareth R. Tibbs, Peter A. Goldstein, Anthony A. Sauve, Rajendra Uprety, James David Warren, Jr., Rebecca L. Joyce, Dipti N. Barman
  • Nicotinoyl riboside compositions and methods of use
    Patent number: 11633414
    Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.
    Type: Grant
    Filed: July 27, 2021
    Date of Patent: April 25, 2023
    Assignee: Cornell University
    Inventors: Anthony A. Sauve, Tianle Yang Redanz
  • Beta-nicotinate ester nucleotides and processes for preparing same
    Patent number: 11530233
    Abstract: The invention provides a compound of formula (I): wherein R is as described herein. The invention also provides a process for the preparation of the compound.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: December 20, 2022
    Assignee: Cornell University
    Inventor: Anthony A. Sauve
  • METHYL AND ETHYL NICOTINATE-RIBOSIDE-5-PHOSPHATES, PREPARATION THEREOF AND METHODS OF USE THEREOF
    Publication number: 20210388018
    Abstract: The invention provides a compound of formula (I): (I) wherein R is methyl or ethyl. The invention also provides a process for the preparation of the compound. The invention further provides a method for increasing cell NAD+ production or improving mitochondrial densities in a cell, wherein the method comprises administering to the cell a compound or salt of the invention.
    Type: Application
    Filed: October 1, 2019
    Publication date: December 16, 2021
    Applicant: Cornell University
    Inventor: Anthony A. Sauve
  • SYNTHESES, ACTIVITIES, AND METHODS OF USE OF DIHYDRONICOTINAMIDE RIBOSIDE DERIVATIVES
    Publication number: 20210355152
    Abstract: Disclosed is a compound of formula (I): wherein R1, R2, R3, and are as defined herein. Also disclosed are methods for increasing mammalian cell NAD+ production and improving mitochondrial cell densities comprising administering to a cell the compound or a salt thereof.
    Type: Application
    Filed: July 27, 2021
    Publication date: November 18, 2021
    Applicant: Cornell University
    Inventors: Anthony Sauve, Farheen Sultana Mohammed, Yue Yang
  • NICOTINOYL RIBOSIDE COMPOSITIONS AND METHODS OF USE
    Publication number: 20210353657
    Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.
    Type: Application
    Filed: July 27, 2021
    Publication date: November 18, 2021
    Applicant: Cornell University
    Inventors: Anthony A. Sauve, Tianle Yang Redanz
  • SUBSTITUTED ALKYLPHENOLS AS HCN1 ANTAGONISTS
    Publication number: 20210267909
    Abstract: Provided herein are compounds (e.g., compounds of Formula (I) and Formula (II), that modulate HCN channels, intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HCN-related disorders (e.g., pain) with the compounds in a subject, by administering the compounds and/or compositions described herein.
    Type: Application
    Filed: June 27, 2019
    Publication date: September 2, 2021
    Applicant: Cornell University
    Inventors: Gareth R. Tibbs, Peter A. Goldstein, Anthony A. Sauve, Rajendra Uprety, James David Warren, Rebecca L. Joyce, Dipti N. Barman
  • Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives
    Patent number: 11098076
    Abstract: Disclosed is a compound of formula (I): wherein R1, R2, R3, and are as defined herein. Also disclosed are methods for increasing mammalian cell NAD+ production and improving mitochondrial cell densities comprising administering to a cell the compound or a salt thereof.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: August 24, 2021
    Assignee: Cornell University
    Inventors: Anthony Sauve, Farheen Sultana Mohammed, Yue Yang
  • Nicotinoyl riboside compositions and methods of use
    Patent number: 11077129
    Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: August 3, 2021
    Assignee: Cornell University
    Inventors: Anthony A. Sauve, Tianle Yang Redanz
  • BETA-NICOTINATE ESTER NUCLEOTIDES AND PROCESSES FOR PREPARING SAME
    Publication number: 20210214386
    Abstract: The invention provides a compound of formula (I): wherein R is as described herein. The invention also provides a process for the preparation of the compound.
    Type: Application
    Filed: March 29, 2021
    Publication date: July 15, 2021
    Applicant: Cornell University
    Inventor: Anthony A. Sauve
  • Efficient synthesis of nicotinamide mononucleotide
    Patent number: 11028118
    Abstract: The invention provides a process for the preparation of nicotinamide mononucleotide having formula (I): The method involves the protection of nicotinamide riboside by ketalization, followed by phosphorylation and then deprotection to provide nicotinamide mononucleotide.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: June 8, 2021
    Assignee: Cornell University
    Inventors: Anthony Sauve, Farheen Sultana Yang Mohammed
  • ?-nicotinate ester nucleotides and process for preparing same
    Patent number: 10961268
    Abstract: The invention provides a compound of formula (I): wherein R is as described herein. The invention also provides a process for the preparation of the compound.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: March 30, 2021
    Assignee: Cornell University
    Inventor: Anthony A. Sauve
  • NICOTINOYL RIBOSIDE COMPOSITIONS AND METHODS OF USE
    Publication number: 20200289535
    Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.
    Type: Application
    Filed: May 29, 2020
    Publication date: September 17, 2020
    Inventors: Anthony A. Sauve, Tianle Yang Redanz
  • EFFICIENT SYNTHESIS OF NICOTINAMIDE MONONUCLEOTIDE
    Publication number: 20200216487
    Abstract: The invention provides a process for the preparation of nicotinamide mononucleotide having formula (I): The method involves the protection of nicotinamide riboside by ketalization, followed by phosphorylation and then deprotection to provide nicotinamide mononucleotide.
    Type: Application
    Filed: March 16, 2020
    Publication date: July 9, 2020
    Applicant: Cornell University
    Inventors: Anthony Sauve, Farheen Sultana Yang Mohammed
  • Nicotinoyl riboside compositions and methods of use
    Patent number: 10668096
    Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: June 2, 2020
    Assignee: CORNELL UNIVERSITY
    Inventors: Anthony A. Sauve, Tianle Yang Redanz
  • Efficient synthesis of nicotinamide mononucleotide
    Patent number: 10590160
    Abstract: The invention provides a process for the preparation of nicotinamide mononucleotide having formula (I): The method involves the protection of nicotinamide riboside by ketalization, followed by phosphorylation and then deprotection to provide nicotinamide mononucleotide.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: March 17, 2020
    Assignee: CORNELL UNIVERSITY
    Inventors: Anthony Sauve, Farheen Sultana Mohammad
  • BETA-NICOTINATE ESTER NUCLEOTIDES AND PROCESS FOR PREPARING SAME
    Publication number: 20200031860
    Abstract: The invention provides a compound of formula (I): wherein R is as described herein. The invention also provides a process for the preparation of the compound.
    Type: Application
    Filed: April 5, 2018
    Publication date: January 30, 2020
    Applicant: Cornell University
    Inventor: Anthony A. Sauve
  • Method of treating heart failure
    Patent number: 10525070
    Abstract: Disclosed herein is a method for treating heart failure in a subject in need thereof. The method includes administering a therapeutically effective amount of nicotinamide riboside to the subject. The heart failure may be associated with iron deficiency. The method may also include administering iron to the subject.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: January 7, 2020
    Assignees: DUKE UNIVERSITY, CORNELL UNIVERSITY
    Inventors: Nancy C. Andrews, Wenjing Xu, Anthony A. Sauve
  • SYNTHESES, ACTIVITIES, AND METHODS OF USE OF DIHYDRONICOTINAMIDE RIBOSIDE DERIVATIVES
    Publication number: 20190382436
    Abstract: Disclosed is a compound of formula (I): wherein R1, R2, R3, and are as defined herein. Also disclosed are methods for increasing mammalian cell NAD+ production and improving mitochondrial cell densities comprising administering to a cell the compound or a salt thereof.
    Type: Application
    Filed: August 26, 2019
    Publication date: December 19, 2019
    Applicant: Cornell University
    Inventors: Anthony Sauve, Farheen Sultana Mohammed, Yue Yang