Patents by Inventor Anthony Sauve

Anthony Sauve has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210267909
    Abstract: Provided herein are compounds (e.g., compounds of Formula (I) and Formula (II), that modulate HCN channels, intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HCN-related disorders (e.g., pain) with the compounds in a subject, by administering the compounds and/or compositions described herein.
    Type: Application
    Filed: June 27, 2019
    Publication date: September 2, 2021
    Applicant: Cornell University
    Inventors: Gareth R. Tibbs, Peter A. Goldstein, Anthony A. Sauve, Rajendra Uprety, James David Warren, Rebecca L. Joyce, Dipti N. Barman
  • Patent number: 11098076
    Abstract: Disclosed is a compound of formula (I): wherein R1, R2, R3, and are as defined herein. Also disclosed are methods for increasing mammalian cell NAD+ production and improving mitochondrial cell densities comprising administering to a cell the compound or a salt thereof.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: August 24, 2021
    Assignee: Cornell University
    Inventors: Anthony Sauve, Farheen Sultana Mohammed, Yue Yang
  • Patent number: 11077129
    Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: August 3, 2021
    Assignee: Cornell University
    Inventors: Anthony A. Sauve, Tianle Yang Redanz
  • Publication number: 20210214386
    Abstract: The invention provides a compound of formula (I): wherein R is as described herein. The invention also provides a process for the preparation of the compound.
    Type: Application
    Filed: March 29, 2021
    Publication date: July 15, 2021
    Applicant: Cornell University
    Inventor: Anthony A. Sauve
  • Patent number: 11028118
    Abstract: The invention provides a process for the preparation of nicotinamide mononucleotide having formula (I): The method involves the protection of nicotinamide riboside by ketalization, followed by phosphorylation and then deprotection to provide nicotinamide mononucleotide.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: June 8, 2021
    Assignee: Cornell University
    Inventors: Anthony Sauve, Farheen Sultana Yang Mohammed
  • Patent number: 10961268
    Abstract: The invention provides a compound of formula (I): wherein R is as described herein. The invention also provides a process for the preparation of the compound.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: March 30, 2021
    Assignee: Cornell University
    Inventor: Anthony A. Sauve
  • Publication number: 20200289535
    Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.
    Type: Application
    Filed: May 29, 2020
    Publication date: September 17, 2020
    Inventors: Anthony A. Sauve, Tianle Yang Redanz
  • Publication number: 20200216487
    Abstract: The invention provides a process for the preparation of nicotinamide mononucleotide having formula (I): The method involves the protection of nicotinamide riboside by ketalization, followed by phosphorylation and then deprotection to provide nicotinamide mononucleotide.
    Type: Application
    Filed: March 16, 2020
    Publication date: July 9, 2020
    Applicant: Cornell University
    Inventors: Anthony Sauve, Farheen Sultana Yang Mohammed
  • Patent number: 10668096
    Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: June 2, 2020
    Assignee: CORNELL UNIVERSITY
    Inventors: Anthony A. Sauve, Tianle Yang Redanz
  • Patent number: 10590160
    Abstract: The invention provides a process for the preparation of nicotinamide mononucleotide having formula (I): The method involves the protection of nicotinamide riboside by ketalization, followed by phosphorylation and then deprotection to provide nicotinamide mononucleotide.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: March 17, 2020
    Assignee: CORNELL UNIVERSITY
    Inventors: Anthony Sauve, Farheen Sultana Mohammad
  • Publication number: 20200031860
    Abstract: The invention provides a compound of formula (I): wherein R is as described herein. The invention also provides a process for the preparation of the compound.
    Type: Application
    Filed: April 5, 2018
    Publication date: January 30, 2020
    Applicant: Cornell University
    Inventor: Anthony A. Sauve
  • Patent number: 10525070
    Abstract: Disclosed herein is a method for treating heart failure in a subject in need thereof. The method includes administering a therapeutically effective amount of nicotinamide riboside to the subject. The heart failure may be associated with iron deficiency. The method may also include administering iron to the subject.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: January 7, 2020
    Assignees: DUKE UNIVERSITY, CORNELL UNIVERSITY
    Inventors: Nancy C. Andrews, Wenjing Xu, Anthony A. Sauve
  • Publication number: 20190382436
    Abstract: Disclosed is a compound of formula (I): wherein R1, R2, R3, and are as defined herein. Also disclosed are methods for increasing mammalian cell NAD+ production and improving mitochondrial cell densities comprising administering to a cell the compound or a salt thereof.
    Type: Application
    Filed: August 26, 2019
    Publication date: December 19, 2019
    Applicant: Cornell University
    Inventors: Anthony Sauve, Farheen Sultana Mohammed, Yue Yang
  • Patent number: 10392414
    Abstract: Disclosed is a compound of formula (I): wherein R1, R2, R3, and are as defined herein. Also disclosed are methods for increasing mammalian cell NAD+ production and improving mitochondrial cell densities comprising administering to a cell the compound or a salt thereof.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: August 27, 2019
    Assignee: CORNELL UNIVERSITY
    Inventors: Anthony Sauve, Farheen Sultana Mohammed, Yue Yang
  • Publication number: 20190192542
    Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.
    Type: Application
    Filed: February 15, 2019
    Publication date: June 27, 2019
    Inventors: Anthony A. Sauve, Tianle Yang Redanz
  • Patent number: 10206940
    Abstract: The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of snaking nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.
    Type: Grant
    Filed: April 25, 2016
    Date of Patent: February 19, 2019
    Assignee: CORNELL UNIVERSITY
    Inventors: Anthony A. Sauve, Tianle Yang Redanz
  • Publication number: 20190038647
    Abstract: Disclosed herein is a method for treating heart failure in a subject in need thereof. The method includes administering a therapeutically effective amount of nicotinamide riboside to the subject. The heart failure may be associated with iron deficiency. The method may also include administering iron to the subject.
    Type: Application
    Filed: February 10, 2016
    Publication date: February 7, 2019
    Inventors: Nancy C. Andrews, Wenjing Xu, Anthony A. Sauve
  • Publication number: 20180291054
    Abstract: The invention provides a process for the preparation of nicotinamide mononucleotide having formula (I): The method involves the protection of nicotinamide riboside by ketalization, followed by phosphorylation and then deprotection to provide nicotinamide mononucleotide.
    Type: Application
    Filed: March 24, 2016
    Publication date: October 11, 2018
    Applicant: Cornell University
    Inventors: Anthony Sauve, Farheen Sultana Mohammad
  • Publication number: 20180208619
    Abstract: Disclosed is a compound of formula (I): wherein R1, R2, R3, and are as defined herein. Also disclosed are methods for increasing mammalian cell NAD+ production and improving mitochondrial cell densities comprising administering to a cell the compound or a salt thereof.
    Type: Application
    Filed: July 15, 2016
    Publication date: July 26, 2018
    Applicant: Cornell University
    Inventors: Anthony Sauve, Farheen Sultana Mohammad, Yue Yang
  • Patent number: 9861651
    Abstract: The invention provides a method of preventing or treating hearing loss in a mammal in need thereof. The method involves administering to the mammal an agent that increases intracellular NAD+ in the mammal. The invention also provides a method of determining if a compound acts as a neuroprotective agent.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: January 9, 2018
    Assignee: CORNELL UNIVERSITY
    Inventors: Kevin Brown, Anthony Sauve, Samie Jaffrey