Abstract: The invention relates to methods for treating prostate cancer by targeting the generation of splice variants of the androgen receptor. In one aspect, this can be achieved by targeting JMJD6 to reduce the production of androgen receptor splice variants. The invention finds particular use in the treatment of prostate cancer that is resistant to conventional androgen therapy.

Abstract: A technique for cooling an air flow through a heat exchanger device involves a controlled change of direction from an air input direction to cooling fins in the heat exchanger device. The heat exchanger device is angled relative to the air stream input direction. The heat exchanger device may include a fluid-carrying conduit, a plurality of sets of cooling fins coupled along the fluid-carrying conduit, and a plurality of air stream deflectors, coupled to the fluid-carrying conduit, that form dividers between the sets of cooling fins. In operation, the air stream deflectors may change in a controlled manner air stream direction from the air stream input direction into a direction approximately parallel with the cooling fins and, after passing out of the cooling fins, change in a controlled manner air stream direction to an air stream output direction.

Abstract: A system for removing heat from a plurality of electronic assemblies including a cabinet having brackets for supporting electronic assemblies in a vertical array between a first vertical airflow path and a second vertical air flow path of the cabinet, and a plinth underlying the cabinet and having an input port receiving air from the first vertical airflow path of the cabinet, an output port transmitting air to the second vertical air flow path, a heat exchanger positioned in an air flow path extending between the input and the output ports, and a fan assembly for driving air through the heat exchanger and towards the input port. The system further includes at least one air flow distribution device establishing a predetermined flow rate distribution through electronic assemblies supported by the brackets.