Patents by Inventor Anthony Simon Lynch

Anthony Simon Lynch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High-throughput screening assays for modulators of nucleic acid topoisomerases
    Patent number: 6197527
    Abstract: This invention provides novel assays for topoisomerase activity and for identifying topoisomerase inhibitors. The assays include both solid-phase and liquid-phase methods that are amenable to high throughput screening methods. The assays of the invention are readily adaptable to numerous types of topoisomerase, and are capable of identifying novel classes of topoisomerase activity modulators.
    Type: Grant
    Filed: July 13, 1999
    Date of Patent: March 6, 2001
    Assignee: Tularik Inc.
    Inventors: Anthony Simon Lynch, Binoj Joseph Matthew
  • High throughput screening assays for nucleic acid ligase modulators
    Patent number: 6153384
    Abstract: Screening assays for identifying ligase activity modulators are provided, in both solid phase and liquid phase formats. Solid phase formats detect ligase activity by ligating a labelled nucleic acid to a capture nucleic acid in the presence of the ligase modulator and detection of the labelled nucleic acid. Liquid phase assays detect ligation-dependent changes in interactive labels between nucleic acids such as proximity quenching of fluorescent labels. Compositions, apparatus and integrated systems for assays are also provided.
    Type: Grant
    Filed: February 19, 1998
    Date of Patent: November 28, 2000
    Assignee: Tularik Inc.
    Inventors: Anthony Simon Lynch, Ashok Ramesh Sanadi, Mohanram Sivaraja
  • High-throughput screening assays for modulators of nucleic acid topoisomerases
    Patent number: 5998152
    Abstract: This invention provides novel assays for topoisomerase activity and for identifying topoisomerase inhibitors. The assays include both solid-phase and liquid-phase methods that are amenable to high throughput screening methods. The assays of the invention are readily adaptable to numerous types of topoisomerase, and are capable of identifying novel classes of topoisomerase activity modulators.
    Type: Grant
    Filed: March 9, 1998
    Date of Patent: December 7, 1999
    Assignee: Tularik Inc.
    Inventors: Anthony Simon Lynch, Binoj Joseph Matthew
  • High-throughput in vitro assays for modulators of peptidyl transferase
    Patent number: 5962244
    Abstract: High-throughput in vitro assays are provided for identifying modulators of peptidyl transferase. New solid-phase assays, related compositions, apparatus and integrated systems are provided.
    Type: Grant
    Filed: May 7, 1998
    Date of Patent: October 5, 1999
    Assignee: Tularik Inc.
    Inventors: Anthony Simon Lynch, Michael Gregory Peterson, Binoj Joseph Matthew