Patents by Inventor Anthony Stepan

Anthony Stepan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for lowering the level of tumor necrosis factor (TNF) in TNF-associated disorders
    Publication number: 20070128177
    Abstract: The present invention provides recombinant adeno-associated virus (rAAV) vectors encoding a tumor necrosis factor (TNF) antagonist and methods using these vectors to reduce levels of TNF in a mammal. The invention also provides methods of using these rAAV vectors in palliating TNF-associated disorders.
    Type: Application
    Filed: July 17, 2006
    Publication date: June 7, 2007
    Inventors: Haim Burstein, Anthony Stepan
  • Amplifiable adeno-associated virus (AAV) packaging cassettes for the production of recombinant AAV vectors
    Publication number: 20060205079
    Abstract: High-efficiency AAV packaging constructs and methods for their use are provided in the present invention. These high-efficiency packaging constructs comprise an activating element (such as the P1 sequence located within the AAV S1 integration site of human chromosome 19) amplifiably linked to one or more AAV packaging genes. The constructs may be either integrated into a mammalian cell genome or maintained episomally. Use of the high-efficiency AAV packaging vectors of the invention provides for controlled amplifiable production of rAAV vector constructs.
    Type: Application
    Filed: January 26, 2006
    Publication date: September 14, 2006
    Inventors: Carmel Lynch, Haim Burstein, Anthony Stepan, Dara Lockert
  • Methods, compositions, and cells for encapsidating recombinant vectors in AAV particles
    Publication number: 20060166318
    Abstract: Isolated recombinant polynucleotides comprising elements which promote encapsidation into AAV particles, packaging cells comprising the recombinant polynucleotides, and methods for their use are provided in the present invention. These isolated recombinant polynucleotides comprise a non-AAV ITR encapsidation element (such as the P1 sequence located within the AAV S1 integration site of human chromosome 19) operably linked to one or more heterologous genes to be encapsidated. The constructs may be either integrated into a mammalian cell genome, maintained episomally, or provided transiently.
    Type: Application
    Filed: January 21, 2005
    Publication date: July 27, 2006
    Applicant: Targeted Genetics Corporation
    Inventors: Dara Lockert, Carmel Lynch, Haim Burstein, Anthony Stepan
  • Amplifiable adeno-associated virus (AAV) packaging cassettes for the production of recombinant AAV vectors
    Publication number: 20050032220
    Abstract: High-efficiency AAV packaging constructs and methods for their use are provided in the present invention. These high-efficiency packaging constructs comprise an activating element (such as the P1 sequence located within the AAV S1 integration site of human chromosome 19) amplifiably linked to one or more AAV packaging genes. The constructs may be either integrated into a mammalian cell genome or maintained episomally. Use of the high-efficiency AAV packaging vectors of the invention provides for controlled amplifiable production of rAAV vector constructs.
    Type: Application
    Filed: July 7, 2003
    Publication date: February 10, 2005
    Inventors: Carmel Lynch, Haim Burstein, Anthony Stepan, Dara Lockert