Abstract: The invention provides materials and methods for purifying nucleic acids from a biological sample held in a container (30) such as a centrifuge tube. A filtration unit (1) having a filter (7, 9) and a filtrate chamber (5) is placed within the container (30). Preferably the exterior of the filtration unit (1) engages sealingly with the interior surface of the container (30). Relative movement between the container (30) and the filtration unit (1) causes the sample to pass through the filter (7, 9) into the filtrate chamber (5), where it can be further manipulated. In preferred embodiments the filtrate is then contacted with a charge-switch nucleic acid binding agent in order to purify the nucleic acid further.

Abstract: Compositions, methods and kits for separating nucleic acid from cell samples. Cells are lysed and nuclear material is flocculated/precipitated. Genomic DNA can be collected from the precipitate and purified. RNA present in the supernatant can be collected (e.g., bound to a solid phase) and purified.

Abstract: A apparatus for assaying glycated proteins and other analytes in biological samples such as blood, in which a sample is presented to the apparatus, includes an inlet port between moveable between first and second inlets, such that the inlet can be brought into liquid communication with each inlet in turn. The inlet port accommodates a filter or binder. The apparatus also includes a microprocessor operable via a key pad, at least one light emitter and at least one light detector, a display and driver, and an A to D converter, and is operatively connected to a power source.