Abstract: A neuromodulation system is provided herein. The system can include a neuromodulation device, an electronics package, which can be part of the neuromodulation device; an external controller; a sensor; and a computing device. The neuromodulation device can include a neuromodulation lead having a lead body configured to be bent to a desired shape and to maintain that shape in order to position the electrodes relative to neural and/or muscular structures when fully deployed. The neuromodulation device can also include an antenna including an upper and a lower coil electrically connected to each other in parallel. The computing device can execute a closed-loop algorithm based on physiological sensed data relating to sleep.

Abstract: One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source. The neuromuscular stimulator can include a controller and at least one electrode. The controller can be configured to receive certain power and stimulation parameters associated with a therapy signal from the power source. The at least one electrode can be configured to deliver the therapy signal to a target tissue associated with control of a posterior base of the tongue of the subject.

Abstract: A neuromodulation lead that is biased towards a substantially omega shape when fully deployed is provided. The neuromodulation lead includes a left set of electrodes disposed on a left portion of the lead body of the neuromodulation lead and a right set of electrodes disposed on a right portion of the lead body of the neuromodulation lead. The neuromodulation lead can be positioned in the plane between the genioglossus muscle and the geniohyoid muscle.

Abstract: One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source. The neuromuscular stimulator can include a controller and at least one electrode. The controller can be configured to receive certain power and stimulation parameters associated with a therapy signal from the power source. The at least one electrode can be configured to deliver the therapy signal to a target tissue associated with control of a posterior base of the tongue of the subject.

Abstract: An intra-oral appliance to power and/or communicate with a neurostimulator is provided. The intra-oral appliance can include a teeth covering configured to fit over mandibular incisor, canine and/or premolar teeth of a human being and a remote controller in the form of a housing extending posteriorly from and operably connected to the teeth covering. The housing can include a power source, a coupling coil configured to transmit power to the neurostimulator and configured to receive power from an external charger, and electrical circuitry operably connected to the coupling coil and the power source.

Abstract: Devices, systems, and methods for treating sleep apnea are disclosed herein. According to some embodiments, the present technology includes an implantable device comprising an electronics package and first and second elongate leads electrically coupled to the electronics package. Each of the first and second leads can comprise (a) a first conductive region configured to be implanted at a first treatment site at an under-chin region of the patient's head, where the first conductive region is configured to deliver a first electrical signal to the first treatment site to thereby activate the genioglossus muscle, and (b) a second conductive region configured to be implanted at a second treatment site at a neck region of the patient, where the second conductive region is configured to deliver a second electrical signal to the second treatment site to thereby activate an infrahyoid strap muscle.

Abstract: A neuromodulation lead that is biased towards a substantially omega shape when fully deployed is provided. The neuromodulation lead includes a left set of electrodes disposed on a left portion of the lead body of the neuromodulation lead and a right set of electrodes disposed on a right portion of the lead body of the neuromodulation lead. The neuromodulation lead can be positioned in the plane between the genioglossus muscle and the geniohyoid muscle.

Abstract: Neuromodulation devices and associated systems and methods are disclosed herein. Various embodiments of the present technology relate to devices, systems, and methods for delivering electrical energy to a hypoglossal nerve of a patient. According to some embodiments, the present technology includes an implantable device comprising a lead and an antenna. The antenna can comprise a planar coil including a conductive wire formed into a wound portion with a plurality of spiral turns, and wherein the coil has a coil width measured in a first dimension and a coil length smaller than the coil width measured in a second dimension. The conductive wire can be biocompatible and non-corrosive.

Abstract: A wireless implantable neuromuscular stimulator includes an antenna for producing an induced current in response to being disposed in an electromagnetic field. The antenna includes a substrate having an upper surface and a lower surface. An upper coil including a plurality of coil turns is disposed on the upper surface of the substrate. A lower coil including a plurality of coil turns is disposed on the lower surface of the substrate. The upper and lower coils are electrically connected to each other in parallel. The parallel connection can be facilitated by a plurality of connectors that extend through the substrate and electrically connect the upper coil to the lower coil. In one example configuration, connectors connect each coil turn of the upper coil to a corresponding turn of the lower coil.

Abstract: A neuromodulation system is provided herein. The system can include a cuff electrode, an electronics package, which can be part of a neuromodulation device; an external controller; a sensor; and a computing device. The neuromodulation device can include an antenna including an upper and a lower coil electrically connected to each other in parallel. The computing device can execute a closed-loop algorithm based on physiological sensed data relating to sleep.

Abstract: A neuromodulation system is provided herein. The system can include a cuff electrode, an electronics package, which can be part of a neuromodulation device; an external controller; a sensor; and a computing device. The neuromodulation device can include an antenna including an upper and a lower coil electrically connected to each other in parallel. The computing device can execute a closed-loop algorithm based on physiological sensed data relating to sleep.

Abstract: According to some embodiments, the present technology includes an implantable device comprising a flexible circuit including a substrate carrying a first antenna (e.g., a power harvesting antenna) configured to operate at a first frequency and a second antenna (e.g., a Bluetooth antenna) configured to operate at a second frequency different from the first frequency. The first antenna can be configured to induce a current in response to being disposed in an alternating electromagnetic field, and the second antenna can be configured to radiate radiofrequency energy to transmit data to an external device.

Abstract: Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.

Abstract: Wireless power transfer devices and associated systems and methods are disclosed herein. Various embodiments of the present technology relate to devices, systems, and methods for delivering power to an implantable device, such as an implantable neuromodulation device configured to modulate a hypoglossal nerve of a patient. According to some embodiments, the present technology includes an external system comprising a control unit coupled to an external device. The external device can comprise a carrier carrying an antenna configured to conduct electrical current such that the antenna generates an electromagnetic field. When the implantable neuromodulation device is positioned within the electromagnetic field generated by the antenna, current can be induced in an antenna of the implantable neuromodulation device such that power is delivered to the implantable neuromodulation device.

Abstract: Neural stimulation is provided according to a closed loop algorithm to treat sleep disordered breathing (SOB), including obstructive sleep apnea (OSA). The closed loop algorithm is executed by a system comprising a processor (which can be within the neural stimulator). The closed loop algorithm includes monitoring physiological data (e.g., EMG data) recorded by a sensor implanted adjacent to an anterior lingual muscle; identifying a trigger within the physiological data, wherein the trigger is identified as a biomarker for a condition related to sleep (e.g., inspiration); and applying a rule-based classification (which can learn) to the trigger to determine whether one or more parameters of a stimulation should be altered based on the biomarker.

Abstract: Methods for analyzing respiration and sleep state of a patient are disclosed herein. Various embodiments of the present technology relate to methods for respiratory analysis. In some embodiments, a method comprises obtaining EMG data using a sensor implanted in a sublingual region of a patient. The EMG data can comprise an EMG waveform indicative of activity of a muscle. The method can further comprise determining an envelope of the EMG waveform, determining an inspiration onset of an upcoming respiratory cycle of the patient, based on the envelope of the EMG waveform, and delivering stimulation energy to a hypoglossal nerve of the patient before the inspiration onset. Alternatively or in combination, embodiments of the present technology can include methods for sleep state detection, sleep disordered breathing event detection, and/or sleep position detection.

Abstract: Neuromodulation devices and associated systems and methods are disclosed herein. Various embodiments of the present technology relate to devices, systems, and methods for delivering electrical energy to a hypoglossal nerve of a patient. According to some embodiments, the present technology includes an implantable neuromodulation device comprising an electronics package, a branched lead body, and an extension portion between the electronics package and lead body. The lead body can comprise a first arm with first conductive elements and a second arm with second conductive elements. The lead body can be configured to be positioned between a patient's genioglossus and geniohyoid muscles such that the first arm and first conductive elements are positioned proximate one of the patient's hypoglossal nerves and the second arm and second conductive elements are positioned proximate a contralateral one of the patient's hypoglossal nerves.

Abstract: One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source. The neuromuscular stimulator can include a controller and at least one electrode. The controller can be configured to receive certain power and stimulation parameters associated with a therapy signal from the power source. The at least one electrode can be configured to deliver the therapy signal to a target tissue associated with control of a posterior base of the tongue of the subject.

Abstract: A neuromodulation lead that is biased towards a substantially omega shape when fully deployed is provided. The neuromodulation lead includes a left set of electrodes disposed on a left portion of the lead body of the neuromodulation lead and a right set of electrodes disposed on a right portion of the lead body of the neuromodulation lead. The neuromodulation lead can be positioned in the plane between the genioglossus muscle and the geniohyoid muscle.

Abstract: Systems and methods for producing asynchronous neural responses to treat pain and/or other patient conditions are disclosed. A method in accordance with a particular embodiment includes selecting a target stimulation frequency that is above a threshold frequency, with the threshold frequency corresponding to a refractory period for neurons of a target sensory neural population. The method can further include producing a patient sensation of paresthesia by directing an electrical signal to multiple sensory neurons of the target sensory neural population at the stimulation frequency, with individual neurons of the sensory neural population completing corresponding individual refractory periods at different times, resulting in an asynchronous sensory neuron response to the electrical signal.