Abstract: Provided herein are compounds according to Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, and R7 are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) as well as the use of such compounds as M4 receptor agonists.

Abstract: The present invention features crystalline forms of Compound I, including polymorphs and pseudopolymorphs, which are useful in the preparation of pharmaceutical compositions.

Abstract: A wearable device utilizing flexible electronics is disclosed. The wearable device may comprise a flexible matrix material and may include sensors for measuring biometric measurements of an individual, an accelerometer for measuring an acceleration of a body part to which the wearable device is attached, a wireless transmitter, a flexible power source, and a microcontroller. During an activity, the microcontroller may receive signals from the sensors including the biometric measurements, and signals from the accelerometer including acceleration and force measurements associated with the individual. The microcontroller may convert the signals into digital signals and transmit the signals to a computing device for analysis. The computing device may analyze the digital signals to determine a performance metric for the individual. The performance metric may be compared to baseline data for the individual to determine a fatigue level, injury risk, or an adjustment to be made by the individual during the activity.

Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: A tool arrangement for forming a tunnel in a vertebra to perform nerve ablation includes a tamp having a distal end portion that includes a tip for creating the tunnel in the vertebra and a curvable portion to direct the tip along a curved path within the vertebra; a first cannula including a cannula body that is straight along an entire length of the cannula body and configured to receive the curvable portion of the tamp and straighten the curvable portion; and a tool hub including a stationary cannula attachment coupled to the first cannula and a movable head coupled to the tamp and configured to move toward or away from the stationary cannula attachment to extend or retract, respectively, the curvable portion of the tamp from or into, respectively, the first cannula.

Abstract: Disclosed are methods for detecting resistance to immune checkpoint blockade inhibition in cancer patients expressing a epidermal growth factor receptor (EGFR) splice variant.

Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).

Abstract: Disclosed herein include antibodies or fragments thereof having specificity to a sarbecovirus spike protein. Also provided are compositions, methods, and kits for using said antibodies or fragments thereof for preventing or treating, for example a coronavirus infection.

Abstract: A system for monitoring a battery module having a plurality of cells includes a sensor adapted to obtain respective cell voltages of the plurality of cells. The controller is adapted to receive data from the sensor, the controller having a processor and tangible, non-transitory memory on which instructions are recorded. The controller is configured to sort the respective cell voltages to create a voltage ranking. The voltage ranking is repeated with at least one new set of cell voltage readings obtained at a predefined checking frequency. Differences in the voltage ranking of the plurality of cells are analyzed. The controller is adapted to control operation of the battery module based in part on differences in the voltage ranking. The controller may be adapted to predict likelihood of a thermal runway event based in part on the differences in the voltage ranking.

Abstract: A computer-controlled robotic arm performs operations upon a workpiece, such as a knife with a blade that requires sharpening, by a set of one or more workstations, such as a grinder and a polisher. A position target having a defined surface profile is attached to the robot arm and scanned by a profilometer to determine a relative position of the arm with respect to a target centerpoint feature. The arm is then used to manipulate the centerpoint feature to locate operating features, such as a grinder's grinding surface, of the various workstations in the robot arm's coordinate system. A workpiece grasped by the robot arm is then scanned along with the target or another target to locate and profile the workpiece relative to the target. Based on the determined profile and positional relationships, the robot arm manipulates the workpieces so as to be operated upon by the workstations.

Abstract: A portable enclosure includes a bottom component including a first sidewall that forms a first door opening. The portable enclosure further includes a top component including a second sidewall that forms a second door opening. The top component is configured to removably attach to the bottom component to align the first door opening and the second door opening and to at least partially enclose an interior volume of the portable enclosure. The portable enclosure further includes a door configured to removably attach to the top component and the bottom component to cover the first door opening and the second door opening.

Abstract: A computer-controlled robotic arm performs operations upon a workpiece, such as a knife with a blade that requires sharpening, by a set of one or more workstations, such as a grinder and a polisher. A position target having a defined surface profile is attached to the robot arm and scanned by a profilometer to determine a relative position of the arm with respect to a target centerpoint feature. The arm is then used to manipulate the centerpoint feature to locate operating features, such as a grinder's grinding surface, of the various workstations in the robot arm's coordinate system. A workpiece grasped by the robot arm is then scanned along with the target or another target to locate and profile the workpiece relative to the target. Based on the determined profile and positional relationships, the robot arm manipulates the workpieces so as to be operated upon by the workstations.

Abstract: A method includes receiving an indication to transmit a first set of signals using a first standard (e.g., Long Term Evolution) via a first set of antennas of a radio frequency device and a second set of signals using a second standard (e.g., New Radio) via a second set of antennas. The method also includes transmitting the first set of signals via the first set of antennas using a first power based on positions of the first set and second set of antennas, exposure conditions of the first set and the second set of signals on a user, and/or priorities of the first and the second set of signals. Moreover, the method includes transmitting the second set of signals via the second set of antennas using a second power based on the positions of the antennas, the exposure conditions of the signals on the user, and/or priorities of the signals.

Abstract: A portable enclosure includes a bottom component including a first sidewall that forms a first door opening. The portable enclosure further includes a top component including a second sidewall that forms a second door opening. The top component is configured to removably attach to the bottom component to align the first door opening and the second door opening and to at least partially enclose an interior volume of the portable enclosure. The portable enclosure further includes a door configured to removably attach to the top component and the bottom component to cover the first door opening and the second door opening.

Abstract: An auto-darkening filter of a welding shield has a brightness-sensing unit, an optical shutter and a processor. The brightness-sensing unit generates a first signal or a second signal. In a high-sensitivity mode, the processor controls the optical shutter to operate in a dark state or a bright state depending on intensity of the first signal being higher or lower than a threshold value. In a low-sensitivity mode, the processor controls the optical shutter to operate in the bright state when intensity of the second signal is lower than the threshold value, and automatically change to the high-sensitivity mode from the low-sensitivity mode when intensity of the second signal is higher than the threshold value.

Abstract: An auto-darkening filter of a welding shield has a brightness-sensing unit, an optical shutter and a processor. The brightness-sensing unit generates a first signal or a second signal. In a high-sensitivity mode, the processor controls the optical shutter to operate in a dark state or a bright state depending on intensity of the first signal being higher or lower than a threshold value. In a low-sensitivity mode, the processor controls the optical shutter to operate in the bright state when intensity of the second signal is lower than the threshold value, and automatically change to the high-sensitivity mode from the low-sensitivity mode when intensity of the second signal is higher than the threshold value.

Abstract: A pair of eyeglasses has a lens body, a frame, two temples and two endpieces. The lens body is formed integrally with two lenses and two engaging members. The frame is mounted detachably on the lens body and has two connecting sections. The temples are pivotally mounted respectively on the engaging members of the lens body. The endpieces pivotally fasten the temples respectively to the engaging members of the lens body. The lens body is formed into a single piece so that lenses are formed without being further fabricated on the rim member.

Abstract: A pair of ventilated goggles has a frame body, a lens and a strap. The frame body includes a rigid frame and a resilient frame. The rigid frame has at least one air passage, at least one retaining wall and a cover board. The at least one air passage is formed through the rigid frame. The at least one retaining wall extends from the rigid frame along one of the at least one air passage. The cover board extends from the rigid frame and is positioned over the at least one air passage and the at least one retaining wall. The resilient frame is formed to the rigid frame. The lens is mounted in the frame body. The headband includes two ends respectively connected to two sides of the frame body. With the above-mentioned structure, an enhanced ventilation effect and greater structural strength can be achieved.

Abstract: A ventilated safety goggle has a lens and a frame. The frame is formed integrally, is mounted around an outer edge of the lens, extends rearward to form a protection cavity and has a circumferential wall encircling the protection cavity and at least one ventilation element. Each ventilation element has a cover and multiple air vents. The cover is formed on and protrudes outward from an outer surface of the circumferential wall of the frame and has a ventilation recess communicating with a rear of the cover. The air vents are formed through the circumferential wall of the frame and communicate the ventilation recess with the protection cavity. Air outside the frame can flow into/out of the protection cavity through the air vents to prevent a user's eyes from a muggy environment. Further, the frame can be easily manufactured by machines to improve a capacity of manufacturing the safety goggle.

Abstract: Spectacles have a frame, a pair of lenses and two nose pads. The frame has two lens mounts and a bridge connecting the lens mounts. The pair of lenses is mounted on the lens mount. Each nose pad has a top and a gear wheel pivoted on the bridge and having a circumferential surface and multiple driving teeth formed on the circumferential surface and meshing with the driving teeth of the gear wheel of the other nose pad. A person can manually turn either of the nose pads to adjust to a desired angle so as to conform to the person's nose, such that the spectacles can be comfortably worn on the person's nose.