Abstract: A power source system including a plurality of cells. The power source system uses electrical charge or current generated by a reaction in at least one of the cells to provide at least one operating material to at least one other of the cells. Optionally, the power source system uses the electrical charge generated by the reaction in the at least one of the cells to provide the at least one operating material to the at least one other of the cells only when the state of charge of the at least one of the cells is equal to or below a threshold or when the use of the cell is equal to or above a threshold. Optionally, in an initial or non-operational state, one or more or each of the cells is dry or without the at least one operating material and the power source system is configured to selectively switch at least one of the plurality of cells from the non-operational state to an operational state by providing the at least one operating material to the at least one cell.

Abstract: An apparatus for controlling water production in a wellbore comprises a body in the form of a base pipe, the base pipe having an axial flow passage in the form of axial throughbore and a lateral flow passage in the form of radial port. A shroud is disposed around the base pipe and forms a housing of the apparatus. In use, the apparatus forms part of a completion string for location in the wellbore, the apparatus configured to direct production fluid into a production conduit for recovery to surface, perform a quantitative measurement of water content within the production fluid, and vary the fluid flow in the fluid flow path based on the quantitative measurement of water content within the production fluid to maintain water production at or below a predetermined threshold.

Abstract: An apparatus for controlling water production in a wellbore comprises a body in the form of a base pipe, the base pipe having an axial flow passage in the form of axial throughbore and a lateral flow passage in the form of radial port. A shroud is disposed around the base pipe and forms a housing of the apparatus. In use, the apparatus forms part of a completion string for location in the wellbore, the apparatus configured to direct production fluid into a production conduit for recovery to surface, perform a quantitative measurement of water content within the production fluid, and vary the fluid flow in the fluid flow path based on the quantitative measurement of water content within the production fluid to maintain water production at or below a predetermined threshold.

Abstract: A power source system including a plurality of cells. The power source system uses electrical charge or current generated by a reaction in at least one of the cells to provide at least one operating material to at least one other of the cells. Optionally, the power source system uses the electrical charge generated by the reaction in the at least one of the cells to provide the at least one operating material to the at least one other of the cells only when the state of charge of the at least one of the cells is equal to or below a threshold or when the use of the cell is equal to or above a threshold. Optionally, in an initial or non-operational state, one or more or each of the cells is dry or without the at least one operating material and the power source system is configured to selectively switch at least one of the plurality of cells from the non-operational state to an operational state by providing the at least one operating material to the at least one cell.

Abstract: The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-ß-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed.

Abstract: The present disclosure is directed to organic electroluminescent devices comprising thermally activated emission material(s) in an emission layer. The present disclosure is also directed to compounds capable of providing thermally activated delayed fluorescence, and to emission layers comprising at least one of the compounds. The compounds may be used in organic layers such as emission layers of an organic electroluminescence device such as fluorescent OLEDs.

Abstract: The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-?-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed.

Abstract: The present disclosure generally relates to diamine compounds, which may be used as precursors in preparing diazaborole compounds and phosphorescent diazaborole metal complexes. The present disclosure also relates to diazaborole compounds, diazaborole metal complexes, and electroluminescent emission materials and electronic devices thereof. The present disclosure further relates to processes for preparing the diamine compounds and diazaborole metal complexes.

Abstract: The present disclosure generally relates to diamine compounds, which may be used as precursors in preparing diazaborole compounds and phosphorescent diazaborole metal complexes. The present disclosure also relates to diazaborole compounds, diazaborole metal complexes, and electroluminescent emission materials and electronic devices thereof. The present disclosure further relates to processes for preparing the diamine compounds and diazaborole metal complexes.

Abstract: The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimized.

Abstract: The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, in a preferred embodiment, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimized.

Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.

Abstract: The present invention relates to the electrodeposition of elemental zirconium at a temperature of less than 100° C. from a mixture of a Lewis acid, a zirconium salt and an ionic liquid.

Abstract: The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-?-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed.

Abstract: The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, in a preferred embodiment, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimised.

Abstract: The present invention provides a method for the synthesis of 18F-labelled biomolecules, which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purification step is required as compared with known methods. Also, one less reagent is required as a particular reagent is employed in two different steps. The chemistry process is thereby simplified, the cost of goods is reduced and the burden of validation and documentation of reagents required for GMP clinical production is minimised.

Abstract: A click chemistry process to be performed with an automated synthesis device using a synthesis cassette includes the steps of performing a chemical reaction in a first vessel at a first elevated temperature, heating the first vessel to a second elevated temperature to cause distillation, delivering a distilled reaction product from the first vessel to a second vessel, performing a click chemistry reaction with the distilled reaction product in the second vessel, purifying the click chemistry product, and formulating a final product from the purified click chemistry product. A cassette and a kit of parts for performing the process are also provided.

Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.

Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.

Abstract: Novel radiotracer(s) for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal, ovarian, endometrial, lung and prostate cancer—primary tumor, nodal disease or metastases). The present invention also describes intermediate(s), pre-cursor(s), pharmaceutical composition(s), methods of making, and methods of use of the novel radiotracer(s).