Patents by Inventor Antimo Gioiello

Antimo Gioiello has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TGR5 modulators and methods of use thereof
    Patent number: 11807659
    Abstract: The application relates to compounds of formula A: or a salt, solvate, ester, tautomer, amino acide conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.
    Type: Grant
    Filed: April 14, 2022
    Date of Patent: November 7, 2023
    Assignee: INTERCEPT PHARMACEUTICALS, INC.
    Inventors: Roberto Pellicciari, Antimo Gioiello, Antonio Macchiarulo, Francoise Perron-Sierra, Klaus Seedorf
  • TGR5 MODULATORS AND METHODS OF USE THEREOF
    Publication number: 20220380404
    Abstract: The application relates to compounds of formula A: or a salt, solvate, ester, tautomer, amino acide conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.
    Type: Application
    Filed: April 14, 2022
    Publication date: December 1, 2022
    Inventors: Roberto PELLICCIARI, Antimo GIOIELLO, Antonio MACCHIARULO, Francoise PERRON-SIERRA, Klaus SEEDORF
  • TGR5 modulators and methods of use thereof
    Patent number: 11345721
    Abstract: The application relates to compounds of formula A: or a salt, solvate, ester, tautomer, amino acid conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.
    Type: Grant
    Filed: September 2, 2020
    Date of Patent: May 31, 2022
    Assignee: INTERCEPT PHARMACEUTICALS, INC.
    Inventors: Roberto Pellicciari, Antimo Gioiello, Antonio Macchiarulo, Francoise Perron-Sierra, Klaus Seedorf
  • 3-desoxy derivative and pharmaceutical compositions thereof
    Patent number: 11319337
    Abstract: The present application provides Compound 1: or a pharmaceutically acceptable salt or amino acid conjugate thereof. The present invention relates to an FXR activator and to methods of making and using said compound.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: May 3, 2022
    Assignee: Intercept Pharmaceuticals, Inc.
    Inventors: Roberto Pellicciari, Antimo Gioiello
  • METHODS AND INTERMEDIATES FOR THE PREPARATION OF BILE ACID DERIVATIVES
    Publication number: 20220127302
    Abstract: The present disclosure relates to methods and novel intermediates useful in the preparation of a compound of formula I or pharmaceutically acceptable salt, hydrate, solvate or amino acid, sulfate or glucuronide conjugate, or prodrug thereof.
    Type: Application
    Filed: June 8, 2021
    Publication date: April 28, 2022
    Inventors: Roberto PELLICCIARI, Antimo GIOIELLO, Gabriel GALVIN, Ronald D. LEWIS, II, Mathew YANIK, Myoung Goo KIM, Frederik Ronald LEUSINK, Bartjan KONING, Thomas HENSEL
  • FARNESOID X RECEPTOR MODULATORS
    Publication number: 20210269475
    Abstract: The present application provides a compound of formula I: or a pharmaceutically acceptable salt, solvate, or amino acid conjugate thereof, wherein R1-R10, m, n, p, and are as described herein. The present invention relates generally to FXR modulators and to methods of making and using said compounds.
    Type: Application
    Filed: May 14, 2021
    Publication date: September 2, 2021
    Inventors: Roberto PELLICCIARI, Antimo GIOIELLO
  • Methods and intermediates for the preparation of bile acid derivatives
    Patent number: 11066437
    Abstract: The present disclosure relates to methods and novel intermediates useful in the preparation of a compound of formula I or pharmaceutically acceptable salt, hydrate, solvate or amino acid, sulfate or glucuronide conjugate, or prodrug thereof, comprising the step of reacting a compound of formula I-4 with a halogenating reagent to provide a compound of formula I-5a
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: July 20, 2021
    Assignee: Intercept Pharmaceuticals, Inc.
    Inventors: Roberto Pellicciari, Antimo Gioiello, Gabriel Galvin, Ronald D. Lewis, II, Mathew Yanik, Myoung Goo Kim, Frederik Ronald Leusink, Bartjan Koning, Thomas Hensel
  • Farnesoid X receptor modulators
    Patent number: 11034717
    Abstract: The present application provides a compound of formula I: or a pharmaceutically acceptable salt, solvate, or amino acid conjugate thereof, wherein R1-R10, m, n, p, and are as described herein. The present invention relates generally to FXR modulators and to methods of making and using said compounds.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: June 15, 2021
    Assignee: Intercept Pharmaceuticals, Inc.
    Inventors: Roberto Pellicciari, Antimo Gioiello
  • TGR5 MODULATORS AND METHODS OF USE THEREOF
    Publication number: 20210122779
    Abstract: The application relates to compounds of formula A: or a salt, solvate, ester, tautomer, amino acid conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.
    Type: Application
    Filed: September 2, 2020
    Publication date: April 29, 2021
    Inventors: Roberto PELLICCIARI, Antimo GIOIELLO, Antonio MACCHIARULO, Francoise PERRON-SIERRA, Klaus SEEDORF
  • 3-DESOXY DERIVATIVE AND PHARMACEUTICAL COMPOSITIONS THEREOF
    Publication number: 20210101927
    Abstract: The present application provides Compound 1: or a pharmaceutically acceptable salt or amino acid conjugate thereof. The present invention relates to an FXR activator and to methods of making and using said compound.
    Type: Application
    Filed: September 18, 2020
    Publication date: April 8, 2021
    Inventors: Roberto Pellicciari, Antimo Gioiello
  • 3-desoxy derivative and pharmaceutical compositions thereof
    Patent number: 10815267
    Abstract: The present application provides Compound 1: or a pharmaceutically acceptable salt or amino acid conjugate thereof. The present invention relates to an FXR activator and to methods of making and using said compound.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: October 27, 2020
    Assignee: Intercept Pharmaceuticals, Inc.
    Inventors: Roberto Pellicciari, Antimo Gioiello
  • TGR5 modulators and methods of use thereof
    Patent number: 10800807
    Abstract: The application relates to compounds of formula A: or a salt, solvate, ester, tautomer, amino acid conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: October 13, 2020
    Assignee: Intercept Pharmaceuticals, Inc.
    Inventors: Roberto Pellicciari, Antimo Gioiello, Antonio Macchiarulo, Francoise Perron-Sierra, Klaus Seedorf
  • TGR5 MODULATORS AND METHODS OF USE THEREOF
    Publication number: 20190284225
    Abstract: The application relates to compounds of formula A: or a salt, solvate, ester, tautomer, amino acid conjugate, or metabolite thereof. The compounds of formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.
    Type: Application
    Filed: June 16, 2016
    Publication date: September 19, 2019
    Inventors: Roberto PELLICCIARI, Antimo GIOIELLO, Antonio MACCHIARULO
  • Methods for preparation of bile acids and derivatives thereof
    Patent number: 10414791
    Abstract: The present application relates to a method of preparing compounds of Formula (I) or a pharmaceutically acceptable salt, solvate, or amino acid conjugate thereof, R1 is H, ?-OH, ?-OH, or an oxo group.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: September 17, 2019
    Assignee: Intercept Pharmaceuticals, Inc
    Inventors: Roberto Pellicciari, Antimo Gioiello
  • METHODS FOR PREPARATION OF BILE ACIDS AND DERIVATIVES THEREOF
    Publication number: 20190010184
    Abstract: The present application relates to a method of preparing compounds of Formula (I) or a pharmaceutically acceptable salt, solvate, or amino acid conjugate thereof, R1 is H, ?-OH, ?-OH, or an oxo group.
    Type: Application
    Filed: July 22, 2016
    Publication date: January 10, 2019
    Inventors: Roberto Pellicciari, Antimo Gioiello
  • 3-DESOXY DERIVATIVE AND PHARMACEUTICAL COMPOSITIONS THEREOF
    Publication number: 20190002493
    Abstract: The present application provides Compound 1: or a pharmaceutically acceptable salt or amino acid conjugate thereof. The present invention relates to an FXR activator and to methods of making and using said compound.
    Type: Application
    Filed: September 6, 2018
    Publication date: January 3, 2019
    Inventors: Roberto Pellicciari, Antimo Gioiello
  • METHODS AND INTERMEDIATES FOR THE PREPARATION OF BILE ACID DERIVATIVES
    Publication number: 20180371009
    Abstract: The present disclosure relates to methods and novel intermediates useful in the preparation of a compound of formula I or pharmaceutically acceptable salt, hydrate, solvate or amino acid, sulfate or glucuronide conjugate, or prodrug thereof.
    Type: Application
    Filed: June 22, 2018
    Publication date: December 27, 2018
    Inventors: Roberto Pellicciari, Antimo Gioiello, Gabriel Galvin, Ronald D Lewis, Mathew Yanik, Myoung Goo Kim, Fred Leusink, Bartjan Koning, Thomas Hensel
  • PROCESS FOR PREPARING BILE ACID DERIVATIVES
    Publication number: 20180079776
    Abstract: The present invention relates to processes for preparing compounds of formula I: or a pharmaceutically acceptable salt or solvate thereof.
    Type: Application
    Filed: August 21, 2017
    Publication date: March 22, 2018
    Inventors: Roberto Pellicciari, Antimo Gioiello
  • Process for preparing bile acid derivatives
    Patent number: 9777038
    Abstract: The present invention relates to processes for preparing compounds of formula I: or a pharmaceutically acceptable salt or solvate thereof.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: October 3, 2017
    Assignee: Intercept Pharmaceuticals, Inc.
    Inventors: Roberto Pellicciari, Antimo Gioiello
  • 3-DESOXY DERIVATIVE AND PHARMACEUTICAL COMPOSITIONS THEREOF
    Publication number: 20170260225
    Abstract: The present application provides Compound 1: or a pharmaceutically acceptable salt or amino acid conjugate thereof. The present invention relates to an FXR activator and to methods of making and using said compound.
    Type: Application
    Filed: March 7, 2017
    Publication date: September 14, 2017
    Inventors: Roberto Pellicciari, Antimo Gioiello