Patents by Inventor Antionette D. Paone

Antionette D. Paone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for Preparing Eptifibatide
    Publication number: 20100105609
    Abstract: The present invention provides, inter alia, convergent processes for preparing eptifibatide that involve coupling a 2-6 eptifibatide fragment to an activated cysteinamide residue to form a 2-7 eptifibatide fragment, attaching a mercaptopropionic acid residue to the 2-7 eptifibatide fragment through disulfide bond formation, coupling the peptide intramolecularly, and removing the protecting group, to form eptifibatide. The invention further provides products produced by the described processes, novel compounds that can be used as synthetic intermediates for the preparation of eptifibatide, and novel compounds that are structurally similar to eptifibatide.
    Type: Application
    Filed: October 23, 2009
    Publication date: April 29, 2010
    Applicants: Millennium Pharmaceuticals, Inc., UBC,S.A.
    Inventors: Guojie Ho, Antionette D. Paone, Luciano Forni, Catherine De Tollenaere, Brice Bonnett, Christine Devijver