Patents by Inventor Antoine Margeot

Antoine Margeot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of Producing Proteins Using a Trichoderma Fungus Strain in Which the CEL1A Gene is Invalidated
    Publication number: 20230303991
    Abstract: The invention relates to the various uses of a fungus strain which belongs to the Trichoderma genus and in which the cel1a gene has been knocked out. The invention relates in particular to a method of producing proteins by a fungus strain which belongs to the Trichoderma genus and in which the cel1a gene has been knocked out, comprising at least two steps: a first step of growth in a batch phase in the presence of at least one carbon growth substrate, and a second step of producing proteins in a fed-batch phase in the presence of a composition comprising at least lactose and a second sugar, the lactose content in the composition representing approximately between 0 and 30% by weight of the total sugar content of the composition, in particular between 5 and 30%.
    Type: Application
    Filed: June 21, 2021
    Publication date: September 28, 2023
    Applicant: IFP Energies Nouvelles
    Inventors: Frédérique Bidard-Michelot, Etienne Jourdier, Vincent Grandperret, Christa Ivanova, Sabine Prigent, Céline Cohen, Antoine Margeot
  • Variants of exoglucanases having improved activity and uses thereof
    Patent number: 11286472
    Abstract: The present invention relates to the expression and optimization of enzymes involved in the breakdown of lignocellulosic biomass. Disclosed are variants of the exoglucanase 1 of Trichoderma reesei, as well as the use of said variants with improved efficiency in methods for breaking down cellulose and for producing biofuel.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: March 29, 2022
    Assignees: IFP Energies nouvelles, Proteus
    Inventors: Cecile Persillon, Christophe Ullmann, Celine Ayrinhac, Olivier Bonzom, Sebastien Fort, Sylvie Armand, Stephanie Pradeau, Antoine Margeot, Lionel Rousseau, Françoise Le Roux
  • VARIANTS OF EXOGLUCANASES HAVING IMPROVED ACTVITY AND USES THEREOF
    Publication number: 20200347371
    Abstract: The present invention relates to the expression and optimisation of enzymes involved in the breakdown of lignocel-lulosic biomass. The present invention specifically relates to variants of the exoglucanase 1 of Trichoderma reesei, as well as to the use of said variants with improved efficiency in methods for breaking down cellulose and for producing biofuel.
    Type: Application
    Filed: February 21, 2020
    Publication date: November 5, 2020
    Inventors: Cecile PERSILLON, Christophe ULLMANN, Celine AYRINHAC, Olivier BONZOM, Sebastien FORT, Sylvie ARMAND, Stephanie PRADEAU, Antoine MARGEOT, Lionel ROUSSEAU, Françoise LE ROUX
  • Mutant Strains of Trichoderma Reesei
    Publication number: 20200270619
    Abstract: The invention relates to a method for producing a protein in a filamentous fungus cell, comprising the overexpression of the TrAZF1 gene or of one of the variants thereof in said cell.
    Type: Application
    Filed: December 21, 2016
    Publication date: August 27, 2020
    Applicant: IFP Energies Nouvelles
    Inventors: Frédérique Bidard-Michelot, Antoine Margeot
  • Variants of exoglucanases having improved activity and uses thereof
    Patent number: 10745679
    Abstract: The present invention relates to the expression and optimization of enzymes involved in the breakdown of lignocellulosic biomass. Disclosed are variants of the exoglucanase 1 of Trichoderma reesei, as well as the use of said variants with improved efficiency in methods for breaking down cellulose and for producing biofuel.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: August 18, 2020
    Assignees: IFP Energies Nouvelles, Centre National De La Recherche Scientifique—CNRS, Proteus
    Inventors: Cecile Persillon, Christophe Ullmann, Celine Ayrinhac, Olivier Bonzom, Sebastien Fort, Sylvie Armand, Stephanie Pradeau, Antoine Margeot, Lionel Rousseau, Françoise Le Roux
  • Variants of exoglucanases having improved activity and uses thereof
    Patent number: 10738291
    Abstract: The present invention relates to the expression and optimisation of enzymes involved in the breakdown of lignocellulosic biomass. The present invention relates to variants of the exoglucanase 2 of Trichoderma reesei, as well as to the use of said variants with improved efficiency in methods for breaking down cellulose and for producing biofuel.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: August 11, 2020
    Assignees: IFP Energies nouvelles, Proteus, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS
    Inventors: Cecile Persillon, Christophe Ullmann, Celine Ayrinhac, Olivier Bonzom, Antoine Margeot, Hugues Mathis, Sebastien Fort, Sylvie Armand, Stephanie Pradeau
  • Hyper-producing trichoderma reesei strain having an enhanced beta-glucosidase activity
    Patent number: 10577668
    Abstract: The present invention relates to a Trichoderma reesei strain which is hyper-producing and which has enhanced ?-glucosidase activity, as well as the use of said strain.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: March 3, 2020
    Assignee: IFP Energies Nouvelles
    Inventors: Frédérique Bidard-Michelot, Laetitia Chan Ho Tong, Antoine Margeot, Céline Cohen
  • Hyper-Producing Trichoderma Reesei Strain Having an Enhanced Beta-Glucosidase Activity
    Publication number: 20190100814
    Abstract: The present invention relates to a Trichoderma reesei strain which is hyper-producing and which has enhanced ?-glucosidase activity, as well as the use of said strain.
    Type: Application
    Filed: September 26, 2018
    Publication date: April 4, 2019
    Applicant: IFP Energies Nouvelles
    Inventors: Frédérique Bidard-Michelot, Laetitia Chan Ho Tong, Antoine Margeot, Céline Cohen
  • Endoglucanase variants having improved activity, and uses of same
    Patent number: 10000780
    Abstract: Disclosed are variants of Trichoderma reesei endoglucanase I, and methods for using such variants to break down cellulose and produce biofuel.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: June 19, 2018
    Assignees: IFP ENERGIES NOUVELLES, PROTEUS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS
    Inventors: Antoine Margeot, Yves Benoit, Cecile Persillon, Celine Ayrinhac, Christophe Ullmann, Olivier Bonzom, Sebastien Fort, Sylvie Armand, Maud Petit, Marine Lenon
  • Endoglucanase variants having improved activity, and uses of same
    Patent number: 9920308
    Abstract: The present invention relates to the expression and optimization of enzymes involved in the breakdown of lignocellulosic biomass. The present invention relates more specifically to variants of Trichoderma reesei endoglucanase II, and the use of said variants having an improved performance in methods of breaking down cellulose and producing biofuel.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: March 20, 2018
    Assignees: IFP ENERGIES NOUVELLES, PROTEUS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS
    Inventors: Antoine Margeot, Senta Blanquet, Cecile Persillon, Celine Ayrinhac, Christophe Ullmann, Olivier Bonzom, Sebastien Fort, Sylvie Armand, Marine Lenon, Maud Petit
  • VARIANTS OF EXOGLUCANASES HAVING IMPROVED ACTIVITY AND USES THEREOF
    Publication number: 20170152497
    Abstract: The present invention relates to the expression and optimisation of enzymes involved in the breakdown of lignocellulosic biomass. The present invention specifically relates to variants of the exoglucanase 1 of Trichoderma reesei, as well as to the use of said variants with improved efficiency in methods for breaking down cellulose and for producing biofuel.
    Type: Application
    Filed: June 12, 2015
    Publication date: June 1, 2017
    Inventors: Cecile PERSILLON, Christophe ULLMANN, Celine AYRINHAC, Olivier BONZOM, Sebastien FORT, Sylvie ARMAND, Stephanie PRADEAU, Antoine MARGEOT, Lionel ROUSSEAU, Françoise LE ROUX
  • VARIANTS OF EXOGLUCANASES HAVING IMPROVED ACTIVITY AND USES THEREOF
    Publication number: 20170152498
    Abstract: The present invention relates to the expression and optimisation of enzymes involved in the breakdown of lignocellulosic biomass. The present invention specially relates to variants of the exoglucanase 2 of Trichoderma reesei, as well as to the use of said variants with improved efficiency in methods for breaking down cellulose and for producing biofuel.
    Type: Application
    Filed: June 12, 2015
    Publication date: June 1, 2017
    Inventors: Cecile PERSILLON, Christophe ULLMANN, Celine AYRINHAC, Olivier BONZOM, Antoine MARGEOT, Hugues MATHIS, Sebastien FORT, Sylvie ARMAND, Stephanie PRADEAU
  • ENDOGLUCANASE VARIANTS HAVING IMPROVED ACTIVITY, AND USES OF SAME
    Publication number: 20160298156
    Abstract: The present invention relates to the expression and optimisation of enzymes involved in the breakdown of lignocellulosic biomass. The present invention relates more specifically to variants of Trichoderma reesei endoglucanase I, and the use of said variants having an improved performance in methods of breaking down cellulose and producing biofuel.
    Type: Application
    Filed: November 21, 2014
    Publication date: October 13, 2016
    Inventors: Antoine MARGEOT, Yves BENOIT, Cécile PERSILLON, Céline AYRINHAC, Christophe ULLMANN, Olivier BONZOM, Sébastien FORT, Sylvie ARMAND, Maud PETIT, Marine LENON
  • ENDOGLUCANASE VARIANTS HAVING IMPROVED ACTIVITY, AND USES OF SAME
    Publication number: 20160289661
    Abstract: The present invention relates to the expression and optimisation of enzymes involved in the breakdown of lignocellulosic biomass. The present invention relates more specifically to variants of Trichoderma reesei endoglucanase II, and the use of said variants having an improved performance in methods of breaking down cellulose and producing biofuel.
    Type: Application
    Filed: November 21, 2014
    Publication date: October 6, 2016
    Inventors: Antoine MARGEOT, Senta BLANQUET, Cecile PERSILLON, Celine AYRINHAC, Christophe ULLMANN, Olivier BONZOM, Sebastien FORT, Sylvie ARMAND, Marine LENON, Maud PETIT
  • Polypetide with enhanced beta-glucosidase activity at low temperature
    Patent number: 9382555
    Abstract: The invention relates to a polypeptide which has enhanced beta-glucosidase activity at a temperature of between about 30° C. and about 35° C.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: July 5, 2016
    Assignees: IFP ENERGIES NOUVELLES, PROTÉUS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS
    Inventors: Antoine Margeot, Hugues Mathis, Celine Ayrinhac, Christophe Ullmann, Cecile Persillon, Sebastien Fort, Sylvie Armand, Maud Petit
  • Beta-glucosidase variants having improved activity, and uses thereof
    Patent number: 9309538
    Abstract: The present invention relates to the expression and optimization of enzymes involved in lignocellulosic biomass decomposition. The present invention relates more particularly to beta-glucosidase variants comprising at least one modification among the amino acids located at positions 225, 238, 240 and 241, according to the numbering in SEQ ID No. 2 of Trichoderma reesei beta-glucosidase, and also relates to the use of said variants having improved effectiveness in methods for cellulose decomposition and biofuel production.
    Type: Grant
    Filed: September 10, 2009
    Date of Patent: April 12, 2016
    Assignees: IFP Energies Nouvelles, PROTEUS
    Inventors: Nicolas Lopes-Ferreira, Antoine Margeot, Hugues Mathis, Laurent Fourage
  • Multi-Enzymatic Preparation Containing the Secretome of an Aspergillus Japonicus Strain
    Publication number: 20150232899
    Abstract: The invention relates to a multi-enzymatic preparation containing the secretome of the CNCM I-4639 strain of Aspergillus japonicus. This secretome, which contains in particular cellulases and hemicellulases, can be used for the saccharification of lignocellulosic substrates, in particular in combination with the secretome of Trichoderma reesei.
    Type: Application
    Filed: September 10, 2013
    Publication date: August 20, 2015
    Inventors: Jean-Guy Berrin, David Navarro, Nicolas Lopes-Ferreira, Antoine Margeot, Pedro Coutinho, Bernard Henrissat
  • Polypetide with Reinforced Beta-Glucosidase Activity at Low Temperature
    Publication number: 20150218593
    Abstract: The invention relates to a polypeptide which has enhanced beta-glucosidase activity at a temperature of between about 30° C. and about 35° C.
    Type: Application
    Filed: September 4, 2013
    Publication date: August 6, 2015
    Inventors: Antoine Margeot, Hugues Mathis, Céline Ayrinhac, Christophe Ullmann, Cécile Persillon, Sébastien Fort, Sylvie Armand, Maud Petit
  • Complementation of the secretome limiting microbiological contaminations within the context of industrial processes
    Patent number: 8518679
    Abstract: The present invention describes the use of a genetically improved Trichoderma reesei strain allowing to limit microbiological contaminations during an industrial process. The genetic strain improvement allows the latter to overexpress an extracellular protein having known antimicrobial properties and compatible with the secretory system of strains of fungi such as Trichoderma reesei. This modified strain can be used to produce the cellulolytic and/or hemicellulolytic enzymes used in a method of producing ethanol from cellulosic or lignocellulosic materials referred to as “second generation” materials.
    Type: Grant
    Filed: December 16, 2008
    Date of Patent: August 27, 2013
    Assignee: IFP Energies Nouvelles
    Inventors: Nicolas Lopes Ferreira, Antoine Margeot
  • Beta-Glucosidase Variants Having Improved Activity, and Uses Thereof
    Publication number: 20110171674
    Abstract: The present invention relates to the expression and optimization of enzymes involved in lignocellulosic biomass decomposition. The present invention relates more particularly to beta-glucosidase variants comprising at least one modification among the amino acids located at positions 225, 238, 240 and 241, according to the numbering in SEQ ID No. 2 of Trichoderma reesei beta-glucosidase, and also relates to the use of said variants having improved effectiveness in methods for cellulose decomposition and biofuel production.
    Type: Application
    Filed: September 10, 2009
    Publication date: July 14, 2011
    Applicant: IFP Energies Nouvelles
    Inventors: Nicolas Lopes-Ferreira, Antoine Margeot, Hugues Mathis, Laurent Fourage