Abstract: The invention relates to a medical implant (1) comprising a patch (2). The implant is adapted to close a defect (3), preferably a an opening in a ventricular or atrial septum (4). The medical implant (1) comprises at least one mechanical anchor (5). The anchor may comprise a barb (6) and is adapted to pierce the patch (2) and/or biological tissue (4) such as to fix the medical implant (1) to said tissue (4). The medical implant can be deployed by a delivery device (7). The delivery device (7) may comprise a balloon (8?, 8?), preferably at least two balloons (8?, 8?).

Abstract: The present invention relates to particular ROR gamma inhibitors for use for treating ROR? dependent cancer or metastasis, particularly prostate cancer, such as castration-resistant prostate cancer.

Abstract: The invention relates to a medical implant (1) that is adapted to repair or close defect (D), in particular an opening in a ventricular, atrial, or septal wall (W). The medical implant (1) may, in particular, be a patch. It comprises an adhesive composition (6). It further comprises two states, wherein in the first state, the medical implant (1) can be deployed to an implant site while the adhesive composition (6) is inactive. It can be brought into a second state by an activation mechanism. The adhesive composition (6), in the second state, is curable by a curing mechanism.

Abstract: The invention relates to medical implant (1) that is adapted to close a defect (D) or a cavity, preferably a defect in an atrial or septal wall (W) or a left atrial appendage. The implant (1) comprises an occlusion device (6) and has two states. It is adapted to, in a first state, be deployed to a defect site (D), where it can be brought into a second state by an activation mechanism. It is adapted to close said defect (D) in said second state.

Abstract: The invention relates to a positioning device (1) comprising a distal part (8) that is adapted to be delivered through a defect, preferably an opening in a ventricular or atrial septum. It comprises a mechanism to selectively expand the distal part (8), such that before expansion, it can be deployed through said defect, and upon expansion, is mechanically prevented from being retracted through the same defect. Thus, the positioning device (1) is temporarily engaged at the defect site.