Abstract: A method for producing a eukaryotic production cell line expressing a protein of interest (POI), comprising a) incorporating a gene of interest (GOI) encoding said POI into the chromosome of a eukaryotic host cell within an exogenous euchromatin protein expression locus by transfection, thereby obtaining a repertoire of recombinant host cells in a pool; b) selecting a single cell from said pool within 12 days after transfection, wherein selecting is at least according to the expression of said GOI or a marker indicating said expression; and c) isolating and expanding the selected single cell, thereby obtaining the production cell line.

Abstract: The invention relates to a cytotoxic modular antibody with a molecular weight of up to 60 kD, specifically binding to a cell surface target with a binding affinity of Kd<10?8 M, a method of producing such antibody and its use as a therapeutic.

Abstract: An integrated capacitor includes a substrate with a first main surface area and an opposing second main surface area. A capacitor structure with a dielectric layer is integrated in the first main surface area. A compensation structure with a compensation layer is integrated in the second main surface area. The ratio between a surface enlargement of the second main surface area effected by the compensation structure corresponds to at least 30% of the surface enlargement of the first main surface area effected by the capacitor structure.

Abstract: An integrated capacitor includes a substrate with a first main surface area and an opposing second main surface area. A capacitor structure with a dielectric layer is integrated in the first main surface area. A compensation structure with a compensation layer is integrated in the second main surface area. The ratio between a surface enlargement of the second main surface area effected by the compensation structure corresponds to at least 30% of the surface enlargement of the first main surface area effected by the capacitor structure.

Abstract: An integrated capacitor includes a substrate with a first main surface area and an opposing second main surface area. A capacitor structure with a dielectric layer is integrated in the first main surface area. A compensation structure with a compensation layer is integrated in the second main surface area. The ratio between a surface enlargement of the second main surface area effected by the compensation structure corresponds to at least 30% of the surface enlargement of the first main surface area effected by the capacitor structure.

Abstract: The invention relates to a cytotoxic;modular antibody with a molecular weight of up to 6OkD, specifically binding to a cell surface target with a binding affinity of Kd<10?8 M, a method of producing such antibody and its use as a therapeutic.

Abstract: The invention relates to a cytotoxic modular antibody with a molecular weight of up to 60 kD, specifically binding to a cell surface target with a binding affinity of Kd<10?8 M, a method of producing such antibody and its use as a therapeutic.

Abstract: The invention relates to a cytotoxic modular antibody with a molecular weight of up to 6 OkD, specifically binding to a cell surface target with a binding affinity of Kd<10?8 M, a method of producing such antibody and its use as a therapeutic.

Abstract: An integrated capacitor includes a substrate with a first main surface area and an opposing second main surface area. A capacitor structure with a dielectric layer is integrated in the first main surface area. A compensation structure with a compensation layer is integrated in the second main surface area. The ratio between a surface enlargement of the second main surface area effected by the compensation structure corresponds to at least 30% of the surface enlargement of the first main surface area effected by the capacitor structure.

Abstract: The invention relates to a cytotoxic modular antibody with a molecular weight of up to 6OkD, specifically binding to a cell surface target with a binding affinity of Kd<10?8 M, a method of producing such antibody and its use as a therapeutic.

Abstract: The invention relates to a cytotoxic modular antibody with a molecular weight of up to 6 OkD, specifically binding to a cell surface target with a binding affinity of Kd<10?8 M, a method of producing such antibody and its use as a therapeutic.

Abstract: According to the present invention there is provided a method of producing a protein in a eukaryotic cell line, comprising the steps of a) providing a backbone of an artificial chromosome, b) recombining the nucleic acid encoding said protein into said backbone to generate an expression vector, c) introducing said expression vector into a eukaryotic host cell line to obtain a eukaryotic expression cell line, d) cultivating said expression cell line to produce said protein, and e) isolating said protein. The invention further relates to respective vectors and transgenic cell lines.

Abstract: A mobile workstation includes a first battery bracket for releasable attachment of a main battery, a second battery bracket for releasable attachment of a backup battery and a power control circuit. The power control circuit includes a first input for receiving and monitoring power from the main battery, a second input for receiving and monitoring power from the backup battery, and a DC output. The power control circuit selectively routes a first flow of electricity from the main battery to the DC output when the first flow of electricity exceeds a predetermined value, and routes a second flow of electricity from the backup battery to the DC output when the first flow of electricity falls below the predetermined value.

Abstract: According to the present invention there is provided a method of producing a protein in a eukaryotic cell line, comprising the steps of a) providing a backbone of an artificial chromosome, b) recombining the nucleic acid encoding said protein into said backbone to generate an expression vector, c) introducing said expression vector into a eukaryotic host cell line to obtain a eukaryotic expression cell line, d) cultivating said expression cell line to produce said protein, and e) isolating said protein. The invention further relates to respective vectors and transgenic cell lines.

Abstract: The invention relates to a cytotoxic modular antibody with a molecular weight of up to 6 OkD, specifically binding to a cell surface target with a binding affinity of Kd<10?8 M, a method of producing such antibody and its use as a therapeutic.

Abstract: In an apparatus for molding particularly a tubular blank (1) of a ductile metal with internal high pressure in a mold, which has a cavity (5), a lower part (2) and a removable upper part (3) as well as a mechanism (6, 7, 13-21) for holding the upper (3) and lower parts (2) together, this mechanism consists of a pot (7), which is provided with a lid (15) and in which the mold (2, 3) is inserted. Between the pot (7) and the lid (15), a bayonet lock (13-20) is provided with a row of interlocking devices (14, 19), which can be brought into and out of engagement by means of a ring (16), which can be rotated relative to the mold (2, 3), and with an annular (9; 21) introduction of force into the lower part (2) and the upper part (3) near their circumference.

Abstract: In an apparatus for molding particularly a tubular blank of a ductile metal with internal high pressure in a mold having a cavity, which apparatus has a pressure-medium connection, which can be advanced from one base (10) and can be applied tightly against the one end of the tubular blank and a seal or a second pressure-medium connection, which can be advanced from a second base (11) and can be applied tightly against the other end, the mold or the pot (3) accommodating the mold has a circular cross section in the horizontal plane and, starting from the two bases (10; 11) with two tie rods (25; 26), a yoke (28; 29) is placed about the mold or the pot (3) and one (11) of the two bases can be moved on an arc (14) about the vertical axis (12) of the mold or the pot (3) and can be fixed at different places.

Abstract: A window cage for a cylindrical roller bearing includes a U-shaped cross section, annular cage having opposite cage rings which engage the ends of the rollers and webs joining the cage rings and extending between the rollers. The opposite sides of each web converge in the radial direction inwardly of the pocket recesses for the rollers. Therefore, spaced apart, opposing sides of two adjacent webs converge in the radial direction outwardly of the pocket recesses to engage a roller in the recess from behind. Radially outward beyond the converging surfaces, the web sides have generally parallel surfaces which are spaced apart slightly less than the diameter of the roller. Recesses are defined in the cage rings at the bottoms of the pocket recesses.

Abstract: A control circuit for supplying a relatively constant operating voltage to an electrical load over a relatively wide range of supply line voltages, including an electronic switch connected in series with the electrical load and having a control lead, a reference voltage generating element, and a comparator for receiving the reference voltage and a voltage representative of the actual voltage applied to the electrical load and for generating and electrical signal which is applied to the control lead of the electronic switch.

Abstract: A vibrating armature motor, which includes a voltage source, an armature, an electromagnet having at least one exciter coil disposed adjacent the armature, a spring for rotationally biasing the armature, a sensor element for sensing the rotational velocity of the armature and for generating a signal proportional to the sensed velocity, a variable duty cycle pulse generator for generating a stream of triggering pulses, the duty cycle of the triggering pulses being dependent upon the sensor signal, and an electronic switch for controlling the current flow from the voltage source through the exciter coil in response to the triggering pulses.