Patents by Inventor Anton Berns

Anton Berns has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination comprising a CDK inhibitor and doxorubicin
    Publication number: 20050222054
    Abstract: A first aspect of the invention relates to a combination comprising a CDK inhibitor and doxorubicin. A second aspect of the invention relates to a pharmaceutical product comprising a CDK inhibitor and doxorubicin as a combined preparation for simultaneous, sequential or separate use in therapy. A third aspect of the invention relates to a method of treating a proliferative disorder, said method comprising simultaneously, sequentially or separately administering a CDK inhibitor and doxorubicin to a subject.
    Type: Application
    Filed: September 27, 2004
    Publication date: October 6, 2005
    Applicant: Cyclacel Limited
    Inventors: Roger Sleigh, Anton Berns, Helen Coley, Scott Lyons
  • Gene targeting in animal cells using isogenic DNA constructs
    Publication number: 20040107452
    Abstract: The present invention provides novel methods for modifying the genome of an animal cell which typically comprise the steps of: constructing a DNA molecule in which desired sequence modifications are contained in a segment of DNA (a “targeting DNA”) that is substantially isogenic with a DNA in the cell genome (a “target DNA”); introducing the targeting DNA construct into the cell (e.g., by microinjection, electroporation, transfection, or calcium phosphate precipitation); and selecting cells in which the desired sequence modifications have been introduced into the genome via homologous recombination.
    Type: Application
    Filed: November 24, 2003
    Publication date: June 3, 2004
    Applicant: GENPHARM INTERNATIONAL, INC.
    Inventors: Anton Berns, Els Robanus Maandag, Hein Te Riele
  • High efficiency gene targeting in mouse embryonic stem cells
    Patent number: 6653113
    Abstract: The present invention provides novel methods for modifying the genome of an animal cell which typically comprise the steps of: constructing a DNA molecule in which desired sequence modifications are contained in a segment of DNA (a “targeting DNA”) that is substantially isogenic with a DNA in the cell genome (a “target DNA”); introducing the targeting DNA construct into the cell (e.g., by microinjection, electroporation, transfection, or calcium phosphate precipitation); and selecting cells in which the desired sequence modifications have been introduced into the genome via homologous recombination.
    Type: Grant
    Filed: February 19, 1999
    Date of Patent: November 25, 2003
    Assignee: Genpharm International, Inc.
    Inventors: Anton Berns, Els Robanus Maandag, Hein te Riele
  • Gene targeting in animal cells using isogenic DNA constructs
    Patent number: 5789215
    Abstract: The present invention provides novel methods for modifying the genome of an animal cell which typically comprise the steps of: constructing a DNA molecule in which desired sequence modifications are contained in a segment of DNA (a "targeting DNA") that is substantially isogenic with a DNA in the cell genome (a."target DNA"); introducing the targeting DNA construct into the cell (e.g., by microinjection, electroporation, transfection, or calcium phosphate precipitation); and selecting cells in which the desired sequence modifications have been introduced into the genome via homologous recombination.
    Type: Grant
    Filed: August 7, 1997
    Date of Patent: August 4, 1998
    Assignee: GenPharm International
    Inventors: Anton Berns, Els Robanus Maandag, Hein te Riele
  • Homologous recombination in mammalian cells
    Patent number: 5721367
    Abstract: The invention relates to methods for intracellularly producing DNA segments by homologous recombination of smaller overlapping DNA fragments and transgenic mammalian cells and transgenic non-human mammals produced by such methods.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 24, 1998
    Assignee: Pharming B.V.
    Inventors: Robert M. Kay, Anton Berns, Paul Krimpenfort, Frank Pieper, Rein Strijker
  • Homologous recombination in mammalian cells
    Patent number: 5612205
    Abstract: The invention relates to methods for intracellularly producing DNA segments by homologous recombination of smaller overlapping DNA fragments and transgenic mammalian cells and transgenic non-human mammals produced by such methods.
    Type: Grant
    Filed: March 1, 1993
    Date of Patent: March 18, 1997
    Assignee: GenPharm International, Incorporated
    Inventors: Robert M. Kay, Anton Berns, Paul Krimpenfort, Frank Pieper, Rein Strijker