Abstract: The disclosed compositions and methods relate to the increasing muscle mass, preventing muscle atrophy, promoting muscle growth, as well as treatment of various other conditions and diseases. In certain aspects, the disclosed compositions are comprised dileucine and leucine and pharmaceutically acceptable salts thereof. In certain aspects, disclosed compositions are administered to subjects in need thereof to increase muscle mass, prevent muscle atrophy, and/or promote muscle growth.

Abstract: The disclosed compositions and methods relate to the increasing muscle mass, preventing muscle atrophy, promoting muscle growth, as well as treatment of various other conditions and diseases. In certain aspects, the disclosed compositions are comprised dileucine and leucine and pharmaceutically acceptable salts thereof. In certain aspects, disclosed compositions are administered to subjects in need thereof to increase muscle mass, prevent muscle atrophy, and/or promote muscle growth.

Abstract: A machine-implemented method creates collections of chemical structures exhibiting a certain degree of structural similarity with exemplified compounds. Specific examples are extracted from a patent. Molecular structure fingerprints are calculated for the specific examples. Markush structure topology information is obtained from a patent database. Virtual libraries are enumerated using the Markush structure topology information extracted from the database. Molecular structure fingerprint similarity of exemplified compounds is identified by comparing the fingerprints with the molecular fingerprints calculated from a randomly enumerated set of chemical compounds. A subset of randomly enumerated chemical structures, which exhibit a similarity range within a user specified similarity range with the fingerprint calculated from the exemplified compounds, is then selected.

Abstract: The invention relates to machine assisted analysis of information encoded by generic chemical structure representations, and to methods for processing these structures.

Abstract: This invention is directed to compounds of formula Ia, Ib or Ic and to pharmaceutical compositions thereof: or a prodrug thereof and a pharmaceutically acceptable carrier, wherein the R groups are defined in the specification; and, in which the dashed line represents an optional double bond. The invention is also directed to methods of treating, diagnosing, and preventing disorders of the central nervous system that are associated with 5HT receptors, including obesity, attention deficit disorder, migraine, depression, epilepsy, anxiety, Alzheimer's disease, withdrawal from drug abuse, pain, schizophrenia, stress-related disorders, panic disorder, sleep disorders, phobias, obsessive compulsive disorder, post-traumatic-stress syndrome, immune system depression, stress-induced gastrointestinal dysfunction, stress-induced cardiovascular dysfunction, and sexual dysfunction.

Abstract: A process is disclosed for producing imidazolidone intermediates from 2H-chromene. The intermediates are useful for synthesizing biotin.

Abstract: A process is disclosed for producing imidazolidone intermediates from 2H-chromene. The intermediates are useful for synthesizing biotin.

Abstract: A process is disclosed for producing imidazolidone intermediates from 2H-chromene. The intermediates are useful for synthesizing biotin.