Patents by Inventor Anton Ilyuk

Anton Ilyuk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EXTRACELLULAR VESICLE BIOMARKERS FOR PANCREATIC CANCER DETECTION, DIAGNOSIS AND MONITORING
    Publication number: 20250321230
    Abstract: Methods and products for the identification and detection of new pancreatic cancer biomarkers based on proteins in biofluids, such as plasma and serum extracellular vesicles.
    Type: Application
    Filed: June 26, 2025
    Publication date: October 16, 2025
    Applicants: Tymora Analytical Operations, LLC, Beth Israel Deaconess Medical Center
    Inventors: ANTON ILYUK, WEIGUO TAO, BRUNO BOCKORNY, LING HUANG, LAKSHMI MUTHUSWAMY, MANUEL HIDALGO, SENTHIL MUTHUSWAMY
  • METHODS FOR AFFINITY-BASED NON-ANTIBODY CAPTURE AND PURIFICATION OF EXTRACELLULAR VESICLES
    Publication number: 20250244214
    Abstract: A method is disclosed to capture and purify extracellular vesicles from biofluids via lipid affinity-based capture. The EVTRAP (Extracellular Vesicles Total Recovery And Purification) method enables capture of EVs onto modified beads. The EVTRAP method results in fast and reproducible capture and isolation of EVs with greater than 90% recovery yields.
    Type: Application
    Filed: March 20, 2025
    Publication date: July 31, 2025
    Applicant: Tymora Analytical Operations, LLC
    Inventors: Anton Ilyuk, Weiguo Tao
  • EXTRACELLULAR VESICLE BIOMARKERS FOR BLADDER CANCER
    Publication number: 20250199007
    Abstract: Methods and products for the identification and detection of new bladder cancer biomarkers based on proteins and protein phosphorylation in urinary extracellular vesicles.
    Type: Application
    Filed: January 31, 2025
    Publication date: June 19, 2025
    Applicant: Tymora Analytical Operations, LLC
    Inventors: Anton Ilyuk, Weiguo Tao
  • EXTRACELLULAR VESICLE BIOMARKERS FOR ENDOMETRIAL CANCER
    Publication number: 20250138015
    Abstract: A method to isolate proteins from biofluids, such as plasma or uterine lavage, for biomarker discovery or for clinical detection. One or more biofluid samples can be provided wherein the one or more biofluids are selected from plasma or uterine lavage samples. Extracellular vesicles (EV) can be selectively and reversibly binded from the biofluid sample to capture and enrich the EVs of the biofluid sample using Extracellular Vesicles total recovery and purification (EVtrap) or other suitable method. At least one compound in the biofluid samples can be detected. The least one compound can consists of plasma or uterine lavage EV proteins and any combination thereof enriched from the plasma or uterine lavage resulting in a greater than 95% recovery yield, greater than 99% purity and with less than 5% coefficient of variation of the at least one EV compound.
    Type: Application
    Filed: January 7, 2025
    Publication date: May 1, 2025
    Applicant: Tymora Analytical Operations, LLC
    Inventors: Anton Ilyuk, Weiguo Tao
  • Methods for affinity-based non-antibody capture and purification of extracellular vesicles
    Patent number: 12270741
    Abstract: A method is disclosed to capture and purify extracellular vesicles from biofluids via lipid affinity-based capture. The EVTRAP (Extracellular Vesicles Total Recovery And Purification) method enables capture of EVs onto modified beads. The EVTRAP method results in fast and reproducible capture and isolation of EVs with greater than 90% recovery yields.
    Type: Grant
    Filed: April 3, 2019
    Date of Patent: April 8, 2025
    Assignee: Tymora Analytical Operations, LLC
    Inventors: Weiguo A. Tao, Anton Ilyuk
  • EXTRACELLULAR VESICLE BIOMARKERS FOR PANCREATIC CANCER DETECTION, DIAGNOSIS AND MONITORING
    Publication number: 20220291222
    Abstract: Methods and products for the identification and detection of new pancreatic cancer biomarkers based on proteins in biofluids, such as plasma and serum extracellular vesicles.
    Type: Application
    Filed: March 11, 2022
    Publication date: September 15, 2022
    Inventors: Anton Ilyuk, Weiguo A. Tao, BRUNO BOCKORNY, LING HUANG, LAKSHMI MUTHUSWAMY, MANUEL HIDALGO, SENTHIL MUTHUSWAMY
  • EXTRACELLULAR VESICLE BIOMARKERS FOR ENDOMETRIAL CANCER
    Publication number: 20220120750
    Abstract: Methods and products for the identification and detection of new endometrial cancer biomarkers based on proteins in plasma and/or uterine lavage extracellular vesicles.
    Type: Application
    Filed: October 18, 2021
    Publication date: April 21, 2022
    Inventors: Anton Ilyuk, Weiguo A. Tao
  • Extracelluar Vesicle Biomarkers for Bladder Cancer
    Publication number: 20210389327
    Abstract: Methods and products for the identification and detection of new bladder cancer biomarkers based on proteins and protein phosphorylation in urinary extracellular vesicles.
    Type: Application
    Filed: June 14, 2021
    Publication date: December 16, 2021
    Inventors: Weiguo A. Tao, Anton Ilyuk
  • METHODS FOR AFFINITY-BASED NON-ANTIBODY CAPTURE AND PURIFICATION OF EXTRACELLULAR VESICLES
    Publication number: 20190301985
    Abstract: A method is disclosed to capture and purify extracellular vesicles from biofluids via lipid affinity-based capture. The EVTRAP (Extracellular Vesicles Total Recovery And Purification) method enables capture of EVs onto modified beads. The EVTRAP method results in fast and reproducible capture and isolation of EVs with greater than 90% recovery yields.
    Type: Application
    Filed: April 3, 2019
    Publication date: October 3, 2019
    Inventors: Weiguo A. Tao, Anton Ilyuk