Abstract: The invention provides a method for stably cross-linking a first nucleic acid sequence selected for being stably cross-linked in the presence of a second nucleic acid sequence selected for not being stably cross-linked in a nucleic acid molecule. The method comprises providing a nucleic acid sequence that is complementary to the first nucleic acid sequence; hybridizing the first nucleic acid sequence to its complementary sequence; and stably cross-linking the first nucleic acid sequence to the complementary sequence.

Abstract: The invention relates to a method for distinguishing at least two target bio-organic molecules with dyes selected from a pool of at least two dyes, the method comprising: (a) providing a first set of at least two probes, wherein each probe recognizes a target bio-organic molecule in a first set of target bio-organic molecules, and wherein each probe is distinctly-labelled with primary labels that are distinct from one another due to the presence of dyes in distinct ratios; (b) providing a second set of probes distinctly-labelled with said primary labels described in step (a), wherein each probe in said second probe set recognizes a target bio-organic molecule in a second set of target bio-organic molecules; wherein each probe in said first or second probe set is further labelled with the same first binary label, wherein said first binary label is distinct from said primary labels; and (c) contacting said at least two target bio-organic molecules with said probe sets, wherein said target bio-organic molecules

Abstract: The Invention relates to a method for providing at least one selected sequence in a nucleic acid with interstrand cross-links. The method comprises hybridizing at least one selected single strand sequence with a complementary single strand nucleic acid or a functional analogue thereof. The selected sequence or complementary nucleic acid or both comprise a cross-linking agent. The invention also relates to a method, referred to as COBRA, for the labeling of a set of at least two bio-organic molecules with a set of at least two colors, comprising generating said set of colors through combining ratio labeling with binary labeling.

Abstract: The Invention relates to a method for providing at least one selected sequence in a nucleic acid with interstrand cross-links. The method comprises hybridizing at least one selected single strand sequence with a complementary single strand nucleic acid or a functional analogue thereof. The selected sequence or complementary nucleic acid or both comprise a cross-linking agent. The invention also relates to a method, referred to as COBRA, for the labeling of a set of at least two bio-organic molecules with a set of at least two colors, comprising generating said set of colors through combining ratio labeling with binary labeling.