Abstract: Provided is a method of preventing, treating or delaying progression of a disease involving aberrant fibroblast proliferation. The method involves using a compound that reduces the level of tyrosine phosphatase activity effected by the protein EYA1A in the parenchymal organ, a nucleic acid ligase IV inhibitor, or an antisense oligonucleotide against the p53-binding protein 1 (53BP1).

Abstract: Provided is a method of preventing, treating or delaying progression of a disease involving aberrant fibroblast proliferation. The method involves using a compound that reduces the level of tyrosine phosphatase activity effected by the protein EYA1A in the parenchymal organ, a nucleic acid ligase IV inhibitor, or an antisense oligonucleotide against the p53-binding protein 1 (53BP1).

Abstract: Provided is a method of preventing, treating or delaying progression of a disease involving aberrant fibroblast proliferation. The method involves using a compound that reduces the level of tyrosine phosphatase activity effected by the protein EYA1A in the parenchymal organ, a nucleic acid ligase IV inhibitor, or an antisense oligonucleotide against the p53-binding protein 1 (53BP1).

Abstract: The present disclosure is directed to novel therapeutic approaches for the prevention, treatment and/or delaying progression of chronic injury, progressive loss of functional parenchymal cells, or fibrosis of an organ. Specifically disclosed are agents for use in increasing homodimer-formation of ARNT in an organ in the prevention, treatment and/or delaying progression of chronic injury, progressive loss of functional parenchymal cells, or fibrosis of said organ, as further defined in the claims. In embodiments, said agent may be (i) an inhibitor of protein phosphatase 2A (PP2A) activity, (ii) an inhibitor of the transcriptional repressor complex FKBP12/YY1, or (iii) an expression construct, which is capable of over-expressing ARNT in said organ, as well as combinations of (i), (ii), and/or (iii).

Abstract: A drive unit for an aircraft ground wheel associated with a brake unit for braking the ground wheel includes: a driving motor drivingly coupleable to the ground wheel; and a cooling system including at least a drive cooling unit configured to generate a drive cooling air stream for cooling the drive unit and a brake cooling unit configured to generate a brake cooling air stream by sucking in air from the brake unit. A method of controlling such drive unit in which the cooling system is driven by the driving motor of the drive unit includes: decoupling the driving motor from the ground wheel and increasing the rotational speed of the driving motor to increase the amount of generated drive cooling air, when an operating condition of the ground wheel and/or of the drive unit is switched from a propulsion mode to a non-propulsion mode.

Abstract: A drive unit for an aircraft ground wheel associated with a brake unit for braking the ground wheel includes: a driving motor drivingly coupleable to the ground wheel; and a cooling system including at least a drive cooling unit configured to generate a drive cooling air stream for cooling the drive unit and a brake cooling unit configured to generate a brake cooling air stream by sucking in air from the brake unit. A method of controlling such drive unit in which the cooling system is driven by the driving motor of the drive unit includes: decoupling the driving motor from the ground wheel and increasing the rotational speed of the driving motor to increase the amount of generated drive cooling air, when an operating condition of the ground wheel and/or of the drive unit is switched from a propulsion mode to a non-propulsion mode.

Abstract: The invention relates to a method of producing a rotor (10) of an electric machine, the rotor (10) comprising a rotor body (14) adapted to be rotated about a rotor axis (A) as well as at least one rotor component (16) to be mounted to the rotor body (14), said method comprising the steps of: arranging the rotor component (16) on the rotor body (14) and winding a wire-like structure (20) around an outer circumference (12) of the rotor body having the rotor component (16) arranged thereon so as to form a bandage (18), with the wire-like structure (20) during winding thereof being held under an adjustable bias.

Abstract: A modular electrical machine includes multiple integrated rotor modules releasably mounted upon a power transmission member to form a torus-like structure, wherein each integrated rotor module includes a series of parallel rotor plates spaced apart to provide an air gap between successive rotor plates in the series. The rotor plates hold permanent magnets securely within the air gap. Corresponding stator modules, each made of multiple air-cored coils potted in a resin material to form a blade. Each blade is externally supported with respect to the rotor module and is positioned between the permanent magnets within one of the air gaps between successive rotor plates.

Abstract: An electric drive unit for a motor vehicle comprises an electric motor having a motor housing, a stator mounted in the motor housing and having coil-wound poles, a rotor arranged internally of the stator with an air gap present between the stator and the rotor, and a planetary gear system having a sun wheel, a planet carrier, planet wheels and a ring gear. The planet wheels have a maximum diameter and axial positioning that an imaginary common envelope cylinder for all maximum diameters of the planet wheels is located radially inside of the winding heads present on one axial side of the stator and axially beside the portion of the rotor adjoining the air gap and that the planet wheels project in axial direction outwardly beyond said winding heads either not at all or with less than 50% of their tooth width in engagement with the sun wheel.

Abstract: An electric machine (2) comprising a rotor (4) and a stator (6) arranged coaxially therewith, at least one of said rotor (4) and stator (6) being formed of a plurality of parts and there being provided a bandage (16) holding together the plurality of parts of said rotor and/or stator (6), wherein the bandage (16) is formed of an electrically non-conducting fiber material having a coefficient of thermal expansion similar to the coefficient of thermal expansion of the parts of said rotor (4) and/or stator (6).

Abstract: An electric drive unit for a motor vehicle comprises an electric motor having a motor housing, a stator mounted in the motor housing and having coil-wound poles, a rotor arranged internally of the stator with an air gap present between the stator and the rotor, and a planetary gear system having a sun wheel, a planet carrier, planet wheels and a ring gear. The planet wheels have a maximum diameter and axial positioning that an imaginary common envelope cylinder for all maximum diameters of the planet wheels is located radially inside of the winding heads present on one axial side of the stator and axially beside the portion of the rotor adjoining the air gap and that the planet wheels project in axial direction outwardly beyond said winding heads either not at all or with less than 50% of their tooth width in engagement with the sun wheel.

Abstract: An electric machine (2) comprising a rotor (4) and a stator (6) arranged coaxially therewith, at least one of said rotor (4) and stator (6) being formed of a plurality of parts and there being provided a bandage (16) holding together the plurality of parts of said rotor and/or stator (6), wherein the bandage (16) is formed of an electrically non-conducting fiber material having a coefficient of thermal expansion similar to the coefficient of thermal expansion of the parts of said rotor (4) and/or stator (6).

Abstract: Iron is desulfurized with a compacted article composed of calcium carbide and a gas-generating solid whereby the article is disintegrated during desulfurization resulting in a substantial total consumption of the carbide and a resultant decrease of residual carbide in the slag produced.