Patents by Inventor Anton P. McCaffrey

Anton P. McCaffrey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220289786
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Application
    Filed: May 26, 2022
    Publication date: September 15, 2022
    Applicant: TriLink Biotechnologies, LLC
    Inventors: Richard I. HOGREFE, Alexandre LEBEDEV, Anton P. MCCAFFREY, Dongwon SHIN
  • Patent number: 11414453
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Grant
    Filed: August 2, 2021
    Date of Patent: August 16, 2022
    Assignee: TriLink Biotechnologies, LLC
    Inventors: Richard I. Hogrefe, Alexandre Lebedev, Anton P. McCaffrey, Dongwon Shin
  • Publication number: 20210371452
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Application
    Filed: August 2, 2021
    Publication date: December 2, 2021
    Applicant: TriLink Biotechnologies, LLC
    Inventors: Richard I. HOGREFE, Alexandre LEBEDEV, Anton P. MCCAFFREY, Dongwon SHIN
  • Publication number: 20210261597
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7 Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Application
    Filed: November 6, 2020
    Publication date: August 26, 2021
    Applicant: TriLink Biotechnologies, LLC
    Inventors: Richard I. HOGREFE, Alexandre LEBEDEV, Anton P. MCCAFFREY, Dongwon SHIN
  • Patent number: 10913768
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Grant
    Filed: September 20, 2016
    Date of Patent: February 9, 2021
    Assignee: TRILINK BIOTECHNOLOGIES, INC.
    Inventors: Richard I. Hogrefe, Alexandre Lebedev, Anton P. McCaffrey, Dongwon Shin
  • Patent number: 10519189
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Grant
    Filed: December 26, 2018
    Date of Patent: December 31, 2019
    Assignee: TRILINK BIOTECHNOLOGIES, INC.
    Inventors: Richard I. Hogrefe, Alexandre Lebedev, Anton P. McCaffrey, Dongwon Shin
  • Patent number: 10494399
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: December 3, 2019
    Assignee: TRILINK BIOTECHNOLOGIES, INC.
    Inventors: Richard I. Hogrefe, Alexandre Lebedev, Anton P. McCaffrey, Dongwon Shin
  • Publication number: 20190270766
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Application
    Filed: April 1, 2019
    Publication date: September 5, 2019
    Applicant: TRILINK BIOTECHNOLOGIES, INC.
    Inventors: Richard I. HOGREFE, Alexandre LEBEDEV, Anton P. MCCAFFREY, Dongwon SHIN
  • Publication number: 20190144490
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Application
    Filed: December 26, 2018
    Publication date: May 16, 2019
    Applicant: TRILINK BIOTECHNOLOGIES, INC.
    Inventors: Richard I. Hogrefe, Alexandre Lebedev, Anton P. McCaffrey, Dongwon Shin
  • Publication number: 20180273576
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Application
    Filed: September 20, 2016
    Publication date: September 27, 2018
    Applicant: TRILINK BIOTECHNOLOGIES, INC.
    Inventors: Richard I. HOGREFE, Alexandre LEBEDEV, Anton P. MCCAFFREY, Dongwon SHIN
  • Patent number: 8685937
    Abstract: The present invention relates to optimized aptamers and methods of using these aptamers.
    Type: Grant
    Filed: August 6, 2009
    Date of Patent: April 1, 2014
    Assignee: University of Iowa Research Foundation
    Inventors: Paloma H. Giangrande, James O. McNamara, Anton P. McCaffrey
  • Publication number: 20120297495
    Abstract: Embodiments of the present invention provide methods for targeted inactivation of viral genomes. In one embodiment, zinc-finger proteins in which DNA binding sites are altered such that they recognize and bind different, desired DNA sequences contained in hepatitis B virus (HBV) and that include nuclease domains are used for inactivation. Other embodiments for targeted inactivation of viral genomes use small nucleic acid molecules, such as short micro-RNA molecules or short hairpin RNA molecules capable of mediating RNA interference (RNAi) against the hepatitis B virus.
    Type: Application
    Filed: June 12, 2012
    Publication date: November 22, 2012
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Anton P. McCaffrey, Thomas J. Cradick
  • Patent number: 8232257
    Abstract: Embodiments of the present invention provide methods for targeted inactivation of viral genomes. In one embodiment, zinc-finger proteins in which DNA binding sites are altered such that they recognize and bind different, desired DNA sequences contained in hepatitis B virus (HBV) and that include nuclease domains are used for inactivation. Other embodiments for targeted inactivation of viral genomes use small nucleic acid molecules, such as short micro-RNA molecules or short hairpin RNA molecules capable of mediating RNA interference (RNAi) against the hepatitis B virus.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: July 31, 2012
    Assignee: University of Iowa Research Foundation
    Inventors: Anton P. McCaffrey, Thomas J. Cradick
  • Publication number: 20120014875
    Abstract: The present invention relates to optimized aptamers and methods of using these aptamers.
    Type: Application
    Filed: August 6, 2009
    Publication date: January 19, 2012
    Applicant: University of Iowa Research Foundation
    Inventors: Paloma H. Giangrande, James O. McNamara, Anton P. McCaffrey
  • Publication number: 20100235936
    Abstract: Embodiments of the present invention provide methods for targeted inactivation of viral genomes. In one embodiment, zinc-finger proteins in which DNA binding sites are altered such that they recognize and bind different, desired DNA sequences contained in hepatitis B virus (HBV) and that include nuclease domains are used for inactivation. Other embodiments for targeted inactivation of viral genomes use small nucleic acid molecules, such as short micro-RNA molecules or short hairpin RNA molecules capable of mediating RNA interference (RNAi) against the hepatitis B virus.
    Type: Application
    Filed: March 27, 2008
    Publication date: September 16, 2010
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Anton P. McCaffrey, Thomas J. Cradick