Patents by Inventor Antonella Maffei

Antonella Maffei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GLUCOSE METABOLISM MODULATING COMPOUNDS
    Publication number: 20160311773
    Abstract: The present invention provides, inter alia, dihydropyridone compounds and compositions, including analogs of a vesicular monoamine transporter type 2 (VMAT2) antagonist. The present invention also provides methods of using such compounds/analogs for modulating glucose levels, and/or preventing, treating, or ameliorating the effects of diabetes and hyperglycemia.
    Type: Application
    Filed: April 20, 2015
    Publication date: October 27, 2016
    Inventors: Paul Harris, Antonella Maffei, Yuli Xie, Donald Landry
  • Hypoglycemic dihydropyridones
    Patent number: 9260391
    Abstract: The present invention provides, inter alia, a compound of formula I: wherein the substituent designations are indicated in the Specification. The present invention also provides pharmaceutical compositions comprising a compound of formula I, and methods of treatment or prevention of diabetes or hyperglycemia in a patient, and of normalizing blood glucose levels in a subject, by administering an effective amount of a compound of formula I.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: February 16, 2016
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Yuli Xie, Shixian Deng, Donald W. Landry, Paul Harris, Antonella Maffei
  • Glucose metabolism modulating compounds
    Patent number: 9012471
    Abstract: The present invention provides, inter alia, dihydropyridone compounds and compositions, including analogs of a vesicular monoamine transporter type 2 (VMAT2) antagonist. The present invention also provides methods of using such compounds/analogs for modulating glucose levels, and/or preventing, treating, or ameliorating the effects of diabetes and hyper-glycemia.
    Type: Grant
    Filed: April 10, 2009
    Date of Patent: April 21, 2015
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Paul Harris, Antonella Maffei, Yuli Xie, Donald Landry
  • HYPOGLYCEMIC DIHYDROPYRIDONES
    Publication number: 20110294800
    Abstract: The present invention provides, inter alia, a compound of formula I: wherein the substituent designations are indicated in the Specification. The present invention also provides pharmaceutical compositions comprising a compound of formula I, and methods of treatment or prevention of diabetes or hyperglycemia in a patient, and of normalizing blood glucose levels in a subject, by administering an effective amount of a compound of formula I.
    Type: Application
    Filed: August 7, 2009
    Publication date: December 1, 2011
    Applicant: The Trustees Of Columbia University in the City of New York
    Inventors: Yuli Xie, Shixian Deng, Donald W. Landry, Paul Harris, Antonella Maffei
  • GLUCOSE METABOLISM MODULATING COMPOUNDS
    Publication number: 20110118300
    Abstract: The present invention provides, inter alia, dihydropyridone compounds and compositions, including analogs of a vesicular monoamine transporter type 2 (VMAT2) antagonist. The present invention also provides methods of using such compounds/analogs for modulating glucose levels, and/or preventing, treating, or ameliorating the effects of diabetes and hyper-glycemia.
    Type: Application
    Filed: April 10, 2009
    Publication date: May 19, 2011
    Inventors: Paul Harris, Antonella Maffei, Yuli Xie, Donald Landry
  • METHODS AND COMPOSITIONS FOR MODULATING INSULIN SECRETION AND GLUCOSE METABOLISM
    Publication number: 20100204258
    Abstract: The present invention relates to methods and compositions for treating or ameliorating the effects of diabetes. In addition, the present invention relates to methods and compositions for treating or preventing hyperglycemia, as well as modulating monoamine levels, islet ?-cell insulin secretion, insulin and/or glucagon levels in a patient. In certain preferred embodiments, such methods include administering to a patient an effective amount of a vesicular monoamine transporter type 2 (VMAT2) antagonist, such as tetrabenazine (TBZ), dihydrotetrabenazine (DTBZ), tetrahydroberberine (THB), reserpine, emetine, Compound 6, or enantiomers, optical isomers, diastereomers, N-oxides, crystalline forms, hydrates, metabolites or pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: March 12, 2008
    Publication date: August 12, 2010
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Paul Harris, Yuli Xie, Donald Landry, Shi-Xian Deng, Antonella Maffei
  • Use of Dtbz for Imaging Endocrine Pancreas and Beta Cell Mass In Type 1 Diabetes
    Publication number: 20090202428
    Abstract: The present invention provides non-invasive methods for determining the beta cell mass in the pancreas of a subject by administering to the subject an effective amount of a vesicular monoamine transporter type 2 (VMAT2)-specific radioligand; obtaining at least one computerized image of at least a portion of the pancreas of the subject; and quantitatively analyzing the computerized image in order to determine the beta cell mass in the pancreas of the subject. The present invention additionally provides methods for diagnosing a metabolic neuroendocrine disorder in a subject including insulinoma, diabetes and preclinical diabetes, as well as methods for determining the efficacy of treatment for a metabolic disorder. The present invention further provides methods for assessing the prognosis of a subject at risk for developing diabetes, and methods for managing the treatment or prevention of diabetes.
    Type: Application
    Filed: June 21, 2006
    Publication date: August 13, 2009
    Inventors: Paul Harris, Antonella Maffei, Ronald Van Heertum