Patents by Inventor Antonella Pepe

Antonella Pepe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRUXILLIC ACID MONOESTER-DERIVATIVES AS SELECTIVE FABP5 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
    Publication number: 20230365488
    Abstract: The present invention provides a compound, and method of selectively inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, said compound having the structure:
    Type: Application
    Filed: October 8, 2021
    Publication date: November 16, 2023
    Applicant: The Research Foundation for The State University of New York
    Inventors: Iwao Ojima, Martin Kaczocha, Monaf Awwa, Antonella Pepe
  • 6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use
    Patent number: 11617738
    Abstract: The present invention generally relates to 6-amino-2,4-dihydropyrano [2,3-c] pyrazoles as a ubiquitin specific protease 7 (USP7) inhibitor useful for the treatment of diseases mediated by malfunction of USP7, such as inflammation, cancer, and immunological disorders. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases mediated by malfunction of USP7, in mammals using compounds disclosed herein.
    Type: Grant
    Filed: March 12, 2021
    Date of Patent: April 4, 2023
    Assignee: Purdue Research Foundation
    Inventors: Antonella Pepe, Andrew Mesecar
  • 6-AMINO-2,4-DIHYDROPYRANO [2,3-C] PYRAZOLES AND METHODS OF USE
    Publication number: 20210196684
    Abstract: The present invention generally relates to 6-amino-2,4-dihydropyrano[2,3-c] pyrazoles as a ubiquitin specific protease 7 (USP7) inhibitor useful for the treatment of diseases mediated by malfunction of USP7, such as inflammation, cancer, and immunological disorders. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases mediated by malfunction of USP7, in mammals using compounds disclosed herein.
    Type: Application
    Filed: March 12, 2021
    Publication date: July 1, 2021
    Applicant: Purdue Research Foundation
    Inventors: Antonella Pepe, Andrew Mesecar
  • 6-amino-2,4-dihydropyrano [2,3-c] pyrazoles and methods of use
    Patent number: 10980781
    Abstract: The present invention generally relates to 6-amino-2,4-dihydropyrano [2,3-c] pyrazoles as a ubiquitin specific protease 7(USP7) inhibitor useful for the treatment of diseases mediated by malfunction of USP7, such as inflammation, cancer, and immunological disorders. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases mediated by malfunction of USP7, in mammals using compounds disclosed herein.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: April 20, 2021
    Assignee: Purdue Research Foundation
    Inventors: Antonella Pepe, Andrew Mesecar
  • 6-AMINO-2,4-DIHYDROPYRANO [2,3-C] PYRAZOLES AND METHODS OF USE
    Publication number: 20200078336
    Abstract: The present invention generally relates to 6-amino-2,4-dihydropyrano [2,3-c] pyrazoles as a ubiquitin specific protease 7 (USP7) inhibitor useful for the treatment of diseases mediated by malfunction of USP7, such as inflammation, cancer, and immunological disorders. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases mediated by malfunction of USP7, in mammals using compounds disclosed herein.
    Type: Application
    Filed: March 29, 2018
    Publication date: March 12, 2020
    Applicant: Purdue Research Foundation
    Inventors: Antonella Pepe, Andrew Mesecar