Patents by Inventor Antonin Holy

Antonin Holy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 9-(phosponylmethoxyalkyl) adenines, the method of preparation and utilization thereof
    Patent number: 4808716
    Abstract: The invention relates to 9-(phosphonylmethoxyalkyl)adenines of the general formula I ##STR1## wherein R.sup.1 is a hydrogen atom, and alkyl group containing one to three carbon atoms, or a hydroxymethyl group, R.sup.2 is a methylene, ethylene, propylene, ethylidene, methoxyethylene, benzyloxyethylene, tetrahydropyran-2-yloxyethylene, (1-ethoxyethoxy)ethylene or 1,2-O-isopropylidene-1,2-dihydroxypropylene group the method of their preparation and utilization.Compounds of the general formula I exhibit biological effects (e.g. antiviral) or can be converted into compounds with such effects.
    Type: Grant
    Filed: April 25, 1986
    Date of Patent: February 28, 1989
    Assignee: Ceskoslovenska akademic ved
    Inventors: Antonin Holy, Ivan Rosenberg
  • Therapeutical application of phosphonylmethoxyalkyl adenines
    Patent number: 4724233
    Abstract: The (S) and (RS) forms of certain phosphonylmethoxyalkyl adenines and their salts have an antiviral effect against several DNA viruses and can be used for the treatment of virus diseases in human and veterinary medicine.
    Type: Grant
    Filed: April 21, 1986
    Date of Patent: February 9, 1988
    Assignees: Stichting Rega VZW, Ceskoslovenska Akademie VED
    Inventors: Erik De Clercq, Antonin Holy, Ivan Rosenberg
  • Isomeric O-phosphonylmethyl derivatives of enantiomeric and racemic 9-(2,3-dihydroxypropyl)adenine
    Patent number: 4659825
    Abstract: This invention relates to isomeric O-phosphonylmethyl derivatives of the formula I ##STR1## wherein R.sup.5 designates an adenin-9-yl moiety, R.sup.4 are alternately a hydrogen atom and a --CH.sub.2 P(O)(OH).sub.2 group, and the configuration at the carbon atom in the position 2 is S, R or RS.The compounds according to the invention are biologically active as inhibitors of metabolic processes and in organism they are stable towards enzymes, cleaving phosphomonoester bonds.The said compounds exhibit also chemosterilizing action on insects.
    Type: Grant
    Filed: January 6, 1984
    Date of Patent: April 21, 1987
    Assignee: Ceskoslovenska akademie
    Inventors: Antonin Holy, Ivan Rosenberg, Karel Slama
  • Antivirally active adenine derivatives
    Patent number: 4605658
    Abstract: Certain esters of 3-(adenin-9-yl)-2-hydroxypropanoic acid are disclosed which exhibit an improved broad spectrum antiviral activity while having a low toxicity for living cells. They can be used for treatment of virus diseases in human and veterinary practice.
    Type: Grant
    Filed: October 5, 1984
    Date of Patent: August 12, 1986
    Assignees: Ceskoslovenska Akademie Ved., Stichting Rega VZW
    Inventors: Antonin Holy, Erik de Clercq
  • Therapeutic application of (S) -or (RS)-9-(2, 3-dihydroxypropyl) adenine for use as antiviral agents
    Patent number: 4230708
    Abstract: The specification describes the use of S or RS 9-(2, 3-dihydroxypropyl) adenine either alone or in combination with ara-A for the treatment of virus diseases.
    Type: Grant
    Filed: October 20, 1978
    Date of Patent: October 28, 1980
    Assignees: Stichting Rega V.Z.W., Ceskoslovenska Akademie Ved.
    Inventors: Erik De Clercq, Antonin Holy