Patents by Inventor Antonio Abbate

Antonio Abbate has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of ischemia reperfusion injury using alpha-2 macroglobulin
    Patent number: 10722557
    Abstract: Methods of preventing and/or treating reperfusion injury are provided. The methods involve administering alpha-2-macroglobulin (A2MG) to a subject with ischemia in one or more tissues or organs, in order to prevent or decrease reperfusion injury when blood flow is restored to the tissues or organs (reperfusion). In some aspects, the patient who is treated has had a heart attack (e.g. acute myocardial infarction, AMI) and the ischemic tissue that is protected from reperfusion injury is heart tissue.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: July 28, 2020
    Assignee: Virginia Commonwealth University
    Inventors: Antonio Abbate, Stefano Toldo
  • Compositions and Methods for Modulating Cardiac Conditions
    Publication number: 20200222516
    Abstract: Embodiments herein report methods and compositions for treating cardiac conditions. In certain embodiments, compositions and methods relate to reducing, inhibiting or treating a subject having or suspected of undergoing cardiac remodeling after a cardiac event. Other embodiments herein relate to compounds including naturally occurring and synthetic compositions of alpha-1 antitrypsin and fragments thereof.
    Type: Application
    Filed: November 22, 2019
    Publication date: July 16, 2020
    Inventors: Charles A. Dinarello, Antonio Abbate, Eli C. Lewis
  • Cryopyrin inhibitors for preventing and treating inflammation
    Patent number: 10343985
    Abstract: Inhibitors that are anti-inflammatory agents are provided, as are methods of using the analogs to inhibit inflammation and prevent or treat diseases and conditions associated with inflammation, such as heart failure and autoimmune diseases.
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: July 9, 2019
    Assignee: VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Antonio Abbate, Shijun Zhang, Benjamin Van Tassell
  • TREATMENT OF ISCHEMIA REPERFUSION INJURY USING ALPHA-2 MACROGLOBULIN
    Publication number: 20190142899
    Abstract: Methods of preventing and/or treating reperfusion injury are provided. The methods involve administering alpha-2-macroglobulin (A2MG) to a subject with ischemia in one or more tissues or organs, in order to prevent or decrease reperfusion injury when blood flow is restored to the tissues or organs (reperfusion). In some aspects, the patient who is treated has had a heart attack (e.g. acute myocardial infarction, AMI) and the ischemic tissue that is protected from reperfusion injury is heart tissue.
    Type: Application
    Filed: July 14, 2017
    Publication date: May 16, 2019
    Inventors: Antonio ABBATE, Stefano TOLDO
  • Compositions and Methods for Modulating Cardiac Conditions
    Publication number: 20170209555
    Abstract: Embodiments herein report methods and compositions for treating cardiac conditions. In certain embodiments, compositions and methods relate to reducing, inhibiting or treating a subject having or suspected of undergoing cardiac remodeling after a cardiac event. Other embodiments herein relate to compounds including naturally occurring and synthetic compositions of alpha-1 antitrypsin and fragments thereof.
    Type: Application
    Filed: December 16, 2016
    Publication date: July 27, 2017
    Inventors: Charles A. Dinarello, Antonio Abbate, Eli C. Lewis
  • Compositions and methods for modulating cardiac conditions
    Patent number: 9522179
    Abstract: Embodiments herein report methods and compositions for treating cardiac conditions. In certain embodiments, compositions and methods relate to reducing, inhibiting or treating a subject having or suspected of undergoing cardiac remodeling after a cardiac event. Other embodiments herein relate to compounds including naturally occurring and synthetic compositions of alpha-1 antitrypsin and fragments thereof.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: December 20, 2016
    Assignees: VIRGINIA COMMONWEALTH UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: Charles A. Dinarello, Antonio Abbate, Eli C. Lewis
  • CRYOPYRIN INHIBITORS FOR PREVENTING AND TREATING INFLAMMATION
    Publication number: 20160052876
    Abstract: Inhibitors that are anti-inflammatory agents are provided, as are methods of using the analogs to inhibit inflammation and prevent or treat diseases and conditions associated with inflammation, such as heart failure and autoimmune diseases.
    Type: Application
    Filed: October 30, 2015
    Publication date: February 25, 2016
    Inventors: Antonio ABBATE, Shijun ZHANG, Benjamin VAN TASSELL
  • Compositions and methods for modulating cardiac conditions
    Publication number: 20130195859
    Abstract: Embodiments herein report methods and compositions for treating cardiac conditions. In certain embodiments, compositions and methods relate to reducing, inhibiting or treating a subject having or suspected of undergoing cardiac remodeling after a cardiac event. Other embodiments herein relate to compounds including naturally occurring and synthetic compositions of alpha-1 antitrypsin and fragments thereof.
    Type: Application
    Filed: March 4, 2011
    Publication date: August 1, 2013
    Applicants: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, VIRGINIA COMMONWEALTH UNIVERSITY
    Inventors: Charles A. Dinarello, Antonio Abbate, Eli C. Lewis