Patents by Inventor Antonio Almario Garcia

Antonio Almario Garcia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 6-cycloamino-3-(pyrid-4-yl)imidazo[1,2-b]pyridazine derivatives, preparation thereof and therapeutic use thereof
    Patent number: 8846676
    Abstract: The invention relates to the 6-cycloamino-3-(pyridin-4-yl)imidazo[I,2-b]pyridazine derivatives corresponding to general formula (I): Wherein R2, R3, R7, R8, A, L and B are as defined herein. Also disclosed are the preparative methods and therapeutic use thereof.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: September 30, 2014
    Assignee: Sanofi
    Inventors: Antonio Almario Garcia, Mathieu Barrague, Philippe Burnier, Cecile Enguehard-Gueiffier, Zhongli Gao, Pascal George, Alain Gueiffier, Adrien Tak Li, Frederic Peuch, Roy Vaz, Qiuxia Zhao
  • Polysubstituted 2-aryl-6-phenylimidazo[1,2-A]pyridine derivatives, and preparation and therapeutic use thereof
    Patent number: 8507520
    Abstract: Compounds of formula (I): wherein R, R1, R2, R3, R4, and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: August 13, 2013
    Assignee: Sanofi
    Inventors: Danielle De Peretti, Yannick Evanno, Patrick Lardenois, Nathalie Rakotoarisoa, Antonio Almario Garcia, André Malanda
  • 6-cycloamino-3-(pyrid-4-yl)imidazo[1,2-b]pyridazine derivatives, preparation thereof and therapeutic use thereof
    Patent number: 8354405
    Abstract: The invention relates to the 6-cycloamino-3-(pyridin-4-yl)imidazo[I,2-b]pyridazine derivatives corresponding to general formula (I): Wherein R2, R3, R7, R8, A, L and B are as defined herein. Also disclosed are the preparative methods and therapeutic use thereof.
    Type: Grant
    Filed: December 24, 2009
    Date of Patent: January 15, 2013
    Assignee: Sanofi
    Inventors: Antonio Almario Garcia, Matthieu Barrague, Philippe Burnier, Cécile Enguehard, Zhongli Gao, Pascal George, Alain Gueiffier, Adrien Tak Li, Frédéric Puech, Roy Vaz, Qiuxia Zhao
  • 6-CYCLOAMINO-3-(PYRID-4-YL)IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
    Publication number: 20130012516
    Abstract: The invention relates to the 6-cycloamino-3-(pyridin-4-yl)imidazo[I,2-b]pyridazine derivatives corresponding to general formula (I): Wherein R2, R3, R7, R8, A, L and B are as defined herein. Also disclosed are the preparative methods and therapeutic use thereof.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Applicant: SANOFI
    Inventors: Antonio ALMARIO GARCIA, Matthieu BARRAGUE, Philippe BURNIER, Cécile ENGUEHARD, Zhongli GAO, Pascal GEORGE, Alain GUEIFFIER, Adrien Tak LI, Frédéric PUACH, Roy VAZ, Qiuxia ZHAO
  • Polysubstituted derivatives of 2-heteroaryl-6-phenylimidazo[1,2-]pyridines, and preparation and therapeutic use thereof
    Patent number: 8338451
    Abstract: Compounds of formula (I): wherein R, R1, R2, R3, R4 and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: December 25, 2012
    Assignee: Sanofi
    Inventors: Danielle De Peretti, Yannick Evanno, Patrick Lardenois, David Machnik, Nathalie Rakotoarisoa, Antonio Almario Garcia
  • Substituted tricyclic derivatives
    Patent number: 8273758
    Abstract: Compounds of formula (I): wherein: Z, R1, R2, R3, n, and m are as defined in the disclosure. Also disclosed are methods of preparing the compounds of formula (I) and their use in therapeutics.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: September 25, 2012
    Assignees: Sanofi, Mitsubishi Tanabe Pharma Corporation
    Inventors: Antonio Almario Garcia, Alistair Lochead, Mourad Saady, Philippe Yaiche
  • Derivatives of 1-piperazine- and 1-homopiperazine-carboxylates, preparation method thereof and use of same as inhibitors of the FAAH enzyme
    Patent number: 8114866
    Abstract: The invention relates to a compound having general formula (I): Wherein m, R1 and R2 are as defined herein. The invention also relates to the use of the compound in therapeutics. More specifically, the compounds of the invention are inhibitors of the FAAH enzyme, and therefore, can be used for the treatment of various disorders associated with FAAH enzyme, which include in a non-limiting manner, pain, eating disorders, neurological and psychiatric pathologies, among other disorders.
    Type: Grant
    Filed: February 8, 2010
    Date of Patent: February 14, 2012
    Assignee: Sanofi-Aventis
    Inventors: Ahmed Abouabdellah, Antonio Almario Garcia, Christian Hoornaert, Adrien Tak Li
  • 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-B]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF
    Publication number: 20110312934
    Abstract: The invention relates to 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives of the general formula (I) where: R2 is a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-4-alkyl, C1-4-alkyloxy-C-M-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl>C3-7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-alkyl, C1-4-fluoroalkyl group; R3 is a hydrogen atom or a substituent selected from halogen atoms and the C1-3 alkyl, —NR4R5, hydroxyl or C1-4 alkyloxy groups; A is a C1-7-alkylene group optionally substituted by one or two Ra groups; B is a C1-7-alkylene group optionally substituted by one or two Rb groups; L is either a nitrogen atom optionally substituted by an Rc or Rd group or a carbon atom substituted by an Re1 group and an Rd group or by two Re2 groups; Rd is a group selected from a hydrogen atom or a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkylthio-C1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C1-6-fluoroalkyl, hydroxy-C1-6-alkyl group; Rf is a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cyc
    Type: Application
    Filed: August 12, 2009
    Publication date: December 22, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Antonio Almario Garcia, Philippe Burnier, Sylvain Cote-Des Combes, Jean-François Gibert, Christophe Pacaud, Frédéric Puech, Yulin Chiang, Larry Davis, Zhongli Gao, Qiuxia Zhao
  • Aryloxyalkylcarbamate-type derivatives, preparation method thereof and use of same in therapeutics
    Patent number: 8026258
    Abstract: The invention relates to a compound of formula (I): Wherein m, n, X, Y, R1, R2, R3 and R4 are as defined herein. The invention also relates to the use of same in therapeutics.
    Type: Grant
    Filed: January 21, 2010
    Date of Patent: September 27, 2011
    Assignee: Sanofi-Aventis
    Inventors: Ahmed Abouabdellah, Antonio Almario Garcia, Jacques Froissant, Christian Hoornaert
  • SUBSTITUTED TRICYCLIC DERIVATIVES
    Publication number: 20110224220
    Abstract: Compounds of formula (I): wherein: Z, R1, R2, R3, n, and m are as defined in the disclosure. Also disclosed are methods of preparing the compounds of formula (I) and their use in therapeutics.
    Type: Application
    Filed: December 15, 2010
    Publication date: September 15, 2011
    Applicants: SANOFI-AVENTIS, MITSUBISHI TANABE PHARMA CORPORATION
    Inventors: Antonio Almario GARCIA, Alistair LOCHEAD, Mourad SAADY, Philippe YAICHE
  • Derivatives of alkylpiperazine- and alkylhomopiperazine-carboxylates, preparation method thereof and use of same as fatty acid amido hydrolase enzyme inhibitors
    Patent number: 7973042
    Abstract: The present invention comprises alkylpiperazine- and alkylhomopiperazine carboxylates and their derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase (FAAH) enzyme inhibitors. These derivatives exert various pharmacological activities by interacting, inter alia, with cannabinoid and vanilloid receptors. By inhibiting the metabolic activity of the FAAH enzyme, compounds often responsible for the onset of disease and other pathological conditions are not generated and the incidence of the disease is greatly reduced.
    Type: Grant
    Filed: December 15, 2008
    Date of Patent: July 5, 2011
    Assignee: Sanofi-Aventis
    Inventors: Ahmed Abouabdellah, Antonio Almario Garcia, Christian Hoornaert, Tak Adrien Li
  • 2-aryl-6-phenylimidazo[1,2-a]pyridine derivatives, preparation thereof and therapeutic use thereof
    Patent number: 7915284
    Abstract: The present invention is related to a compound of formula (I) wherein R1, R2, R3 and R4 are as defined herein, or an addition salt of an acid thereof, the pharmaceutical composition and preparation thereof, and the therapeutic use thereof in the treatment or the prevention of diseases involving Nurr-1 nuclear receptors, also known as NR4A2, NOT, TINUR, RNR-1 and HZF3.
    Type: Grant
    Filed: March 19, 2009
    Date of Patent: March 29, 2011
    Assignee: Sanofi-Aventis
    Inventors: Antonio Almario Garcia, Patrick Lardenois, Anne Olivier
  • POLYSUBSTITUTED DERIVATIVES OF 2-HETEROARYL-6-PHENYLIMIDAZO[1,2-a]PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF
    Publication number: 20110065727
    Abstract: Compounds of formula (I): wherein R, R1, R2, R3, R4 and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.
    Type: Application
    Filed: September 14, 2010
    Publication date: March 17, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Danielle DE PERETTI, Yannick EVANNO, Patrick LARDENOIS, David MACHNIK, Nathalie RAKOTOARISOA, Antonio ALMARIO GARCIA
  • POLYSUBSTITUTED 2-ARYL-6-PHENYLIMIDAZO[1,2-A]PYRIDINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC USE THEREOF
    Publication number: 20110065745
    Abstract: Compounds of formula (I): wherein R, R1, R2, R3, R4, and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.
    Type: Application
    Filed: September 14, 2010
    Publication date: March 17, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Danielle DE PERETTI, Yannick EVANNO, Patrick LARDENOIS, Nathalie RAKOTOARISOA, Antonio ALMARIO GARCIA, Andre MALANDA
  • PIPERIDINYLALKYLCARBAMATE DERIVATIVES, METHODS FOR THEIR PREPARATION AND THE THERAPEUTIC USE THEREOF AS FATTY ACID AMIDO HYDROLASE ENZYME INHIBITORS
    Publication number: 20100279998
    Abstract: The present invention relates to piperidinylalkylcarbamate derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase (FAAH) enzyme inhibitors. These derivatives exert various pharmacological activities by interacting, inter alia, with cannabinoid and vanilloid receptors. By inhibiting the metabolic activity of the FAAH enzyme, compounds often responsible for the onset of a large variety of diseases and other pathological conditions are not generated and the incidence of the disease is greatly reduced.
    Type: Application
    Filed: July 12, 2010
    Publication date: November 4, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Ahmed ABOUABDELLAH, Antonio Almario Garcia, Christian Hoornaert, Jean Jeunesse
  • Piperidinylalkylcarbamate derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase enzyme inhibitors
    Patent number: 7781590
    Abstract: The present invention comprises peridinylalkylcarbamate derivatives, methods for their preparation and the therapeutic use thereof as fatty acid amido hydrolase (FAAH) enzyme inhibitors. These derivatives exert various pharmacological activities by interacting, inter alia, with cannabinoid and vanilloid receptors. By inhibiting the metabolic activity of the FAAH enzyme, compounds often responsible for the onset of a large variety of diseases and other pathological conditions are not generated and the incidence of the disease is greatly reduced.
    Type: Grant
    Filed: August 21, 2006
    Date of Patent: August 24, 2010
    Assignee: Sanofi-Aventis
    Inventors: Ahmed Abouabdellah, Antonio Almario Garcia, Christian Hoornaert, Jean Jeunesse
  • 6-CYCLOAMINO-3-(PYRID-4-YL)IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
    Publication number: 20100179154
    Abstract: The invention relates to the 6-cycloamino-3-(pyridin-4-yl)imidazo[I,2-b]pyridazine derivatives corresponding to general formula (I): Wherein R2, R3, R7, R8, A, L and B are as defined herein. Also disclosed are the preparative methods and therapeutic use thereof.
    Type: Application
    Filed: December 24, 2009
    Publication date: July 15, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Antonio ALMARIO GARCIA, Matthieu BARRAGUE, Philippe BURNIER, Cécile ENGUEHARD-GUEIFFIER, Zhongli GAO, Pascal GEORGE, Alain GUEIFFIER, Adrien Tak LI, Frédéric PEUCH, Roy VAZ, Qiuxia ZHAO
  • DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME
    Publication number: 20100137329
    Abstract: The invention relates to a compound having general formula (I): Wherein m, R1 and R2 are as defined herein. The invention also relates to the use of the compound in therapeutics. More specifically, the compounds of the invention are inhibitors of the FAAH enzyme, and therefore, can be used for the treatment of various disorders associated with FAAH enzyme, which include in a non-limiting manner, pain, eating disorders, neurological and psychiatric pathologies, among other disorders.
    Type: Application
    Filed: February 8, 2010
    Publication date: June 3, 2010
    Applicant: SANOFI-EVENTIS
    Inventors: Ahmed ABOUABDELLAH, Antonio Almario Garcia, Christian Hoornaert, Adrien Tak Li
  • ARYLOXYALKYLCARBAMATE-TYPE DERIVATIVES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS
    Publication number: 20100120845
    Abstract: The invention relates to a compound of formula (I): Wherein m, n, X, Y, R1, R2, R3 and R4 are as defined herein. The invention also relates to the use of same in therapeutics.
    Type: Application
    Filed: January 21, 2010
    Publication date: May 13, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Ahmed ABOUABDELLAH, Antonio Almario Garcia, Jacques Froissant, Christian Hoornaert
  • Arylalklcarbamate derivatives, preparation method thereof and use of same in therapeutics
    Patent number: 7696374
    Abstract: The invention relates to a compound having general formula (I): Wherein n, A, R1, R2, and R3 are as defined herein. The invention also relates to methods of preparation of compound of formula (I) as well as its use in therapeutics.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: April 13, 2010
    Assignee: Sanofi-Aventis
    Inventors: Ahmed Abouabdellah, Antonio Almario Garcia