Abstract: The present invention relates to an in vitro method for detecting at least one target poly-nucleotide in a test sample, wherein the method comprises the steps of contacting the test sample with a first oligonucleotide and a second oligonucleotide and detecting the hybridization between the first and the second oligonucleotides to the at least one target polynucleotide. The present invention also relates to devices or systems to implement the method, and kits of parts comprising said oligonucleotides.

Abstract: A microfluidics valve comprises at least two substrates (1) between which there is at least a microchannel (5). It additionally comprises at least a barrier (4) of a meltable material, placed in the microchannel. The valve further comprises at least an optical heater (6) placed in correspondence with the barrier (4) and at least a section of one of the substrates (1), in correspondence with the optical heater (6), is transparent. The optical heater is a colored line that, when is illuminated with a light source, is heated and releases the heat to the barrier (4) thus melting the part of it that is closer to the line.

Abstract: The present invention concerns an ion sensor based on differential measurement, that by means of at least two ion-sensitive field-effect transistors, compares the concentration of certain ions in a solution to be measured with the concentration of certain ions in a reference solution contained in a micro-reservoir with a micro-channel. To do this, the micro-reservoir and the micro-channel cover at least the gate of one of the ion-sensitive field-effect transistors and make up a unit partially filled with a porous material that covers the entirety of the aforementioned gate and at least the base of the micro-channel.

Abstract: The present invention concerns an ion sensor based on differential measurement, that by means of at least two ion-sensitive field-effect transistors, compares the concentration of certain ions in a solution to be measured with the concentration of certain ions in a reference solution contained in a micro-reservoir with a micro-channel. To do this, the micro-reservoir and the micro-channel cover at least the gate of one of the ion-sensitive field-effect transistors and make up a unit partially filled with a porous material that covers the entirety of the aforementioned gate and at least the base of the micro-channel.

Abstract: The invention relates to a device for electrically reading microarrays which can be cleaned and used more than once. The device (1, 1?, 1?) for reading microarrays (6) comprises the following elements: a base (2, 2?, 2?) comprising support means (3, 3?, 3?) for positioning the test surface (7) of the microarray (6) parallel to a reading surface (4) of the base (2, 2?, 2?); a matrix of transducers (5, 5?, 5?) disposed on the reading surface (4) of the base (2, 2?, 2?), transforming a variation of an electrical or chemical value into a variation of an electrical value; and reading means (10) which are connected to the transducers (5, 5?, 5?) and interpret the electrical signals from the transducers (5, 5?, 5?).