Patents by Inventor Antonio CARUSILLO

Antonio CARUSILLO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

MODIFIED CAS9 SYSTEM HAVING A DOMINANT NEGATIVE EFFECTOR ON NON-HOMOLOGOUS END-JOINING FUSED THERETO AND ITS USE FOR IMPROVED GENE EDITING

Publication number: 20240043819

Abstract: The present invention relates to modified Cas9 nuclease comprising a substantial part of a Cas9 nuclease and fused thereto at least one substantial part of a dominant negative effector on non-homologous end-joining selected from the group consisting of RNF168, 53BP1, Ku80 and DNA-PK which compete with NHEJ promoting factors and CtIP.

Type: Application

Filed: July 26, 2021

Publication date: February 8, 2024

Applicant: Albert-Ludwigs-Universitaet Freiburg

Inventors: Claudio MUSSOLINO, Toni CATHOMEN, Tatjana CORNU, Antonio CARUSILLO

MODIFIED CAS9 SYSTEM HAVING A DOMINANT NEGATIVE EFFECTOR ON NON-HOMOLOGOUS END-JOINING FUSED THERETO AND ITS USE FOR IMPROVED GENE EDITING