Abstract: A multi-layer device is provided that is useful in tissue regeneration, for example, for vascular regeneration, e.g., for use in treatment of a coronary vascular disease, such as for treatment of myocardial infarction. A method of making the device also is provided.

Abstract: A multi-layer device is provided that is useful in tissue regeneration, for example, for vascular regeneration, e.g., for use in treatment of a coronary vascular disease, such as for treatment of myocardial infarction. A method of making the device also is provided.

Abstract: An atrioventricular prosthesis device is provided. The device includes a frame at least partially defining and enclosing a central cavity, the frame having a distal portion, a proximal portion, and a middle portion connected therebetween. The device further includes a valve construct formed, at least in part, from a cell growth scaffold, at least partially disposed within the central cavity defined by the frame. The valve construct includes: an annular portion defining an aperture and being connected to the frame for positioning the valve construct within the central cavity of the frame, and a plurality of leaflets extending longitudinally and radially inward from the annular portion. The frame and valve construct are transitionable to a deployed state, in which a diameter of at least a portion of the frame and the valve construct substantially conform to a diameter of a tricuspid and/or mitral valve opening.

Abstract: Provided herein is a prosthetic heart valve device including a biocompatible and biodegradable metal frame comprising a proximal end, a distal end, and a sidewall therebetween, the sidewall having a plurality of openings therethrough. The device further includes a biocompatible and biodegradable polymeric heart valve having an annular portion attached at least one contact point to the proximal end of the frame and at least one leaflet attached to and extending distally from the annular portion.

Abstract: A template for a valve construct for replacement of at least one of a mitral valve and a tricuspid valve includes at least an anterior leaflet portion and at least a posterior leaflet portion, each leaflet portion having a proximal edge, a distal edge, and side edges extending between the proximal edge and the distal edge. The template further includes a plurality of substantially straight elongated chordae portions each having a proximal end connected to the distal edge of one of the at least two leaflet portions and a distal end extending therefrom and one or more papillary muscle head portions formed at a commissure between distal ends of at least two of the plurality of chordae portions. A total width of the leaflet portions of the template is substantially equal to a circumference of a native annulus of a heart valve.

Abstract: A method of making a valve structure includes a step of rotating a mandrel and an electrodeposition target attached to the mandrel about a rotational axis of the mandrel. The target includes an exterior surface having at least one conductive surface portion and at least one non-conductive surface portion. The method also includes a step of electrodepositing a polymer matrix of a biodegradable, biocompatible polymer composition onto the at least one conductive surface portion and the at least one non-conductive surface portion of the exterior surface of the rotating electrodeposition target to form the valve structure.

Abstract: Provided herein is a percutaneous expandable venous cannula device, and related methods. The device is easily inserted, for example, using standard Seldinger technique via the right internal jugular. The device includes multiple, multi-holed limbs that softly fill, e.g., the right atrium to facilitate complete drainage, enable retraction of the chamber in surgery, and mitigate suction occlusion, filling the entire atrium and allowing for efficient and rapid emptying of the chamber. In aspects, the device facilitates minimally-invasive aortic or mitral valve surgery with single placement via the right internal jugular as the sole cannula needed for full support.

Abstract: Provided herein is an electrodeposition apparatus for producing long polymeric threads, yarns, or ropes. A method of preparing long polymeric threads, yarns or ropes also is provided.

Abstract: A multi-layer device is provided that is useful in tissue regeneration, for example, for vascular regeneration, e.g., for use in treatment of a coronary vascular disease, such as for treatment of myocardial infarction. A method of making the device also is provided.

Abstract: An atrioventricular prosthesis device is provided. The device includes a frame at least partially defining and enclosing a central cavity, the frame having a distal portion, a proximal portion, and a middle portion connected therebetween. The device further includes a valve construct formed, at least in part, from a cell growth scaffold, at least partially disposed within the central cavity defined by the frame. The valve construct includes: an annular portion defining an aperture and being connected to the frame for positioning the valve construct within the central cavity of the frame, and a plurality of leaflets extending longitudinally and radially inward from the annular portion. The frame and valve construct are transitionable to a deployed state, in which a diameter of at least a portion of the frame and the valve construct substantially conform to a diameter of a tricuspid and/or mitral valve opening.

Abstract: Methods, systems, and devices are provided herein for preparing fiber matrices with differing degrees of anisotropy within a single matrix and controllable physical parameters, such as porosity.

Abstract: An atrioventricular prosthesis device is provided. The device includes a frame at least partially defining and enclosing a central cavity, the frame having a distal portion, a proximal portion, and a middle portion connected therebetween. The device further includes a valve construct formed, at least in part, from a cell growth scaffold, at least partially disposed within the central cavity defined by the frame. The valve construct includes: an annular portion defining an aperture and being connected to the frame for positioning the valve construct within the central cavity of the frame, and a plurality of leaflets extending longitudinally and radially inward from the annular portion. The frame and valve construct are transitionable to a deployed state, in which a diameter of at least a portion of the frame and the valve construct substantially conform to a diameter of a tricuspid and/or mitral valve opening.

Abstract: A system and method are provided for manufacturing filamentous polymer matrices, comprising electrospinning a polymer fiber into a gap between two or more spaced-apart electrodes.

Abstract: Provided herein is an electrodeposition apparatus for producing long polymeric threads, yarns, or ropes. A method of preparing long polymeric threads, yarns or ropes also is provided.

Abstract: A template for a valve construct for replacement of at least one of a mitral valve and a tricuspid valve includes at least an anterior leaflet portion and at least a posterior leaflet portion, each leaflet portion having a proximal edge, a distal edge, and side edges extending between the proximal edge and the distal edge. The template further includes a plurality of substantially straight elongated chordae portions each having a proximal end connected to the distal edge of one of the at least two leaflet portions and a distal end extending therefrom and one or more papillary muscle head portions formed at a commissure between distal ends of at least two of the plurality of chordae portions. A total width of the leaflet portions of the template is substantially equal to a circumference of a native annulus of a heart valve.

Abstract: A template for a valve construct for replacement of at least one of a mitral valve and a tricuspid valve includes at least an anterior leaflet portion and at least a posterior leaflet portion, each leaflet portion having a proximal edge, a distal edge, and side edges extending between the proximal edge and the distal edge. The template further includes a plurality of substantially straight elongated chordae portions each having a proximal end connected to the distal edge of one of the at least two leaflet portions and a distal end extending therefrom and one or more papillary muscle head portions formed at a commissure between distal ends of at least two of the plurality of chordae portions. A total width of the leaflet portions of the template is substantially equal to a circumference of a native annulus of a heart valve.

Abstract: A method of making a valve structure includes a step of rotating a mandrel and an electrodeposition target attached to the mandrel about a rotational axis of the mandrel. The target includes an exterior surface having at least one conductive surface portion and at least one non-conductive surface portion. The method also includes a step of electrodepositing a polymer matrix of a biodegradable, biocompatible polymer composition onto the at least one conductive surface portion and the at least one non-conductive surface portion of the exterior surface of the rotating electrodeposition target to form the valve structure.

Abstract: Provided herein is a mandrel for use in electrospinning prosthetic valve devices. Also provided are prosthetic valve devices for implantation in an animal or a human. Methods of making and using the valve devices are also provided herein.

Abstract: Provided herein is a prosthetic heart valve device including a biocompatible and biodegradable metal frame comprising a proximal end, a distal end, and a sidewall therebetween, the sidewall having a plurality of openings therethrough. The device further includes a biocompatible and biodegradable polymeric heart valve having an annular portion attached at least one contact point to the proximal end of the frame and at least one leaflet attached to and extending distally from the annular portion.

Abstract: Disclosed herein are devices and methods for accessing the interior of the heart through a wall thereof. The device includes a main body, a flange at an end thereof, and a passage therethrough to allow for access to the interior of the heart when the device is placed on an outer surface thereof. The device can be formed of any suitable biocompatible and/or biodegradable material, and can have a passage sized to allow for transmittance of tools/devices normally used for interventions in the interior of the heart therethrough.